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Application of parasitic loranthus total polysaccharides in preparation of antiabortifacient

A technology of mulberry and total polysaccharides, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of inability to prevent and treat spontaneous abortion safely and effectively, limitations and side effects

Active Publication Date: 2015-01-21
罗颂平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] At present, for the treatment of spontaneous abortion, Western medicine mostly uses expectant therapy, hormone therapy and immunotherapy, but these methods have various limitations and side effects, and cannot prevent and treat spontaneous abortion safely and effectively

Method used

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  • Application of parasitic loranthus total polysaccharides in preparation of antiabortifacient
  • Application of parasitic loranthus total polysaccharides in preparation of antiabortifacient
  • Application of parasitic loranthus total polysaccharides in preparation of antiabortifacient

Examples

Experimental program
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Effect test

preparation example Construction

[0078] Preparation of standard curve: Accurately weigh 0.25 g of anhydrous glucose reference substance, put it in a 250 ml volumetric flask, dissolve it with a small amount of distilled water, and dilute to the mark. Take 1.0, 1.5, 2.0, 2.5, 3.0, 3.5ml respectively in a 50ml volumetric flask, add distilled water to the mark, absorb 2ml of glucose standard solution and blank distilled water, add 1ml of newly prepared 6% phenol, put in ice bath 5 ml of concentrated sulfuric acid was added to the solution, shaken and mixed, placed for 2 min, then heated in a boiling water bath for 15 min, cooled rapidly to room temperature, and the absorbance was measured at a wavelength of 492 nm. Such as figure 1 As shown, draw a standard curve with absorbance A versus concentration C: A=0.0171C+0.0726, R=0.9981.

[0079]

[0080] Preparation of the test solution: Precisely measure 1ml (C=0.5g / ml) of the mulberry polysaccharide extract sample in a 100ml volumetric flask, add water to the m...

Embodiment 1

[0206] Example 1: Extraction of polysaccharides from mulberry parasites

[0207] Extraction of Alcoholic Extract of Morus alba: Take 1000g of dried Morus alba, crush it into a 20-30 mesh coarse powder with a traditional Chinese medicine grinder, add 7L of 95% ethanol to soak for 30 minutes, and then ultrasonicate at 30-40°C for 30 minutes at a frequency of 40KHz. Four layers of gauze filter. The filter residue was soaked in 7L of 95% ethanol for 30 minutes, ultrasonicated at 30-40°C for 30 minutes, ultrasonic frequency 40KHz, filtered with four layers of gauze, and the filter residue was used as water extract for extraction. The filtrate is concentrated under reduced pressure to form an extract, the concentration temperature is 60°C, the concentration speed is 70 rpm (revolutions per minute), and the concentration vacuum is 0.1Mpa. The obtained extract is the sample of the alcoholic extract of Morus japonica.

[0208]Extraction of the water extract after alcohol extraction ...

Embodiment 2

[0214] Example two: Extraction of polysaccharides from Morus spp.

[0215] Extraction of Alcoholic Extract of Morus pilosula: Take 1000g of dried Morus japonica medicinal material, crush it into a 20-mesh coarse powder with a traditional Chinese medicine grinder, add 6L of 95% ethanol to soak for 20 minutes, ultrasonicate at 30°C for 20 minutes, ultrasonic frequency 40KHz, filter with four layers of gauze . The filter residue was soaked in 6L of 95% ethanol for 30 minutes, ultrasonicated at 30°C for 30 minutes, and the ultrasonic frequency was 40KHz, the two extraction solutions were combined, filtered with four layers of gauze, and the filter residue was retained as the water extract for extraction. The filtrate is concentrated under reduced pressure to form an extract, the concentration temperature is 60°C, the concentration speed is 70rpm (rev / min), and the concentration vacuum is 0.1Mpa.

[0216] Extraction of water extract after alcohol extraction of mulberry: After th...

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Abstract

The invention discloses an application of parasitic loranthus total polysaccharides in preparation of an antiabortifacient. The parasitic loranthus total polysaccharides can promote pregnancy deciduas, and expression of estrogen and progestrone receptor of an ovary of an animal model, and can improve serum E2 and P level; secretion within the gestation period is adjusted; colporrhagia of the animal model is reduced; the abortion frequency is lowered; the abortion rate is lowered; gestation of rats is protected from multiple levels and factors; the miscarriage prevention effect is significant; and the curative effect is more excellent than those of parasitic loranthus total extracts.

Description

technical field [0001] The present invention relates to the application of the effective part of Morus chinensis, especially the application of the total polysaccharide of Morus spp. in the preparation of anti-fetal medicine. Background technique [0002] Mulberry parasite (Ramulus Taxilli) is the dry leafy stem branch of the mulberry parasite Taxillus chinensis (DC.) Danser, another name: parasite, parasite on mulberry, and is an evergreen parasitic small shrub. Characters: The stems are cylindrical, 3-4cm long, 0.2-1cm in diameter; the surface is reddish-brown or gray, with fine longitudinal stripes, and there are many small lenticels, and the branchlets have brown-red fine hairs. Sometimes the leaves are shrunken, and the whole ones are oval, entire, brown, leathery, and the young leaves are also covered with brown-red fine hairs. The stem is hard, the section is irregular, the skin is reddish brown, and the wood palm is lighter. Odorless, astringent taste. It is paras...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P15/06A61P15/02A61P7/04A61P5/00A61P15/08C08B37/00
CPCA61K31/715C08B37/00
Inventor 罗颂平郜洁黄长盛刘新玉
Owner 罗颂平
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