Traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation and application thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight: 10-15 parts of peach kernel, 7-12 parts of safflower, 12-18 parts of angelica sinensis, 15-25 parts of radix rehmanniae, 12-18 parts of ligusticum wallichii, 10-15 parts of radix paeoniae rubra, 12-18 parts of radix cyathulae, 12-18 parts of platycodon grandiflorum, 12-18 parts of radix bupleuri, 10-15 parts of bran-fried fructus aurantii, 4-8 parts of honey-fried licorice root, 10-15 parts of ginseng, 8-12 parts of poria cocos, 4-8 parts of rhizoma zingiberis, 10-15 parts of rhizoma cyperi, 12-18 parts of radix curcumae, 10-15 parts of cortex albiziae, 12-18 parts of rhizoma pinelliae preparata, 12-18 parts of exocarpium citri grandis, 20-30 parts of 25 parts of allium macrostemon, 25-35 parts of corn stigma, 15-25 parts of plantain herb and 25-35 parts of oyster; based on the theory of traditional Chinese medicine, all traditional Chinese medicine raw materials are screened, and through the combined action of all the raw materials, the traditional Chinese medicine composition has a remarkable curative effect on atherosclerosis and takes effect quickly.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation and an application thereof. Background Art

[0002] As we age, the function of our internal organs gradually declines, leading to poor circulation of Qi and blood, making atherosclerosis more likely to develop. Studies suggest that the prevalence of atherosclerosis in people over 60 may reach 30%-50%. Atherosclerosis is even more common in people with chronic conditions such as cardiovascular and cerebrovascular disease, diabetes, and cancer. For example, the incidence of atherosclerosis in patients with coronary heart disease can be as high as 70%-80%, while in patients with diabetes, the incidence is approximately 40%-60%.

[0003] Currently, Western medicine treatments for atherosclerosis include: (1) drug therapy, statins, whose structure and principle are: HMG-CoA reductase inhibitors, reduce liver cholesterol synthesis, increase LDL receptor expression, and promote LDL clearance; problems are: some patients develop myopathy and elevated liver enzymes, and long-term use may increase the risk of diabetes. The main reason is: inhibition of the mevalonate pathway affects coenzyme Q10 synthesis, leading to muscle cell energy metabolism disorders. Antiplatelet drugs (such as aspirin, clopidogrel), whose structure and principle are: inhibition of cyclooxygenase (COX) or P2Y12 receptors, reducing platelet aggregation. Problems are: increased bleeding risk, and some patients are clopidogrel-resistant. The main reason is: CYP2C19 gene polymorphism affects the production of clopidogrel active metabolites. PCSK9 inhibitors (such as alirocumab), whose structure and principle are: monoclonal antibodies target PCSK9 protein, prevent LDL receptor degradation, and enhance LDL clearance. Problems are: inconvenient injection and high cost. The main reasons are: the production of biological agents is complex and requires long-term use. (2) Interventional treatment, percutaneous coronary intervention (PCI), structure and principle: stents expand narrowed blood vessels and restore blood flow. Problems are: restenosis in the stent and late thrombosis. The main reasons are: endothelial damage leading to inflammatory response and neointimal hyperplasia. (3) Surgical treatment, coronary artery bypass grafting (CABG), structure and principle: bypassing the narrowed blood vessels and using autologous blood vessels (such as the internal mammary artery and great saphenous vein). Problems are: venous grafts are prone to restenosis and the surgical trauma is large. The main reasons are: the venous wall is thin and is prone to intimal hyperplasia after being subjected to arterial pressure.

[0004] In view of this, the present invention is proposed. Summary of the Invention

[0005] The present invention aims to provide a Chinese medicine composition for preventing and treating atherosclerosis and plaque formation and its application. The Chinese medicine composition of the present invention has the effects of promoting blood circulation and removing blood stasis, soothing the liver and regulating qi, resolving phlegm and removing dampness, relieving chest tightness and promoting yang, and strengthening the spleen and replenishing qi, and has a significant therapeutic effect on atherosclerosis.

[0006] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are adopted:

[0007] The first aspect of the present invention provides a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation, wherein the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0008] 10-15 parts of peach kernel, 7-12 parts of safflower, 12-18 parts of angelica, 15-25 parts of raw earth, 12-18 parts of chuanxiong, 10-15 parts of red peony root, 12-18 parts of cyperus, 12-18 parts of platycodon, 12-18 parts of bupleurum, 10-15 parts of bran-fried aurantium, 4-8 parts of roasted liquorice, 10-15 parts of ginseng, 8-12 parts of poria, 4-8 parts of dried ginger, 1 part of cyperus. 0-15 parts, 12-18 parts of Curcuma zedoaria, 10-15 parts of Albizzia julibrissin bark, 12-18 parts of Pinellia ternata, 12-18 parts of Citrus aurantium, 20-30 parts of Rhizoma Zingiberis, 20-30 parts of Atractylodes macrocephala with bran, 2-4 parts of Scorpion, 1-3 parts of Scolopendra, 15-25 parts of Trichosanthes, 25-35 parts of Allium macrostemon, 50-70 parts of Corn silk, 15-25 parts of Plantago and 25-35 parts of Oyster.

[0009] Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0010] 12 parts of peach kernel, 9 parts of safflower, 15 parts of angelica, 20 parts of raw rehmannia, 15 parts of chuanxiong, 12 parts of red peony root, 15 parts of cyathula, 15 parts of platycodon, 15 parts of bupleurum, 12 parts of stir-fried aurantium with bran, 6 parts of roasted liquorice root, 12 parts of ginseng, 10 parts of poria, 6 parts of dried ginger, 12 parts of cyperus, 15 parts of turmeric, 12 parts of julibrissin bark, 15 parts of qing pinellia, 15 parts of tangerine peel, 24 parts of ginger magnolia bark, 24 parts of stir-fried atractylodes macrocephala, 3 parts of scorpion, 2 parts of centipede, 20 parts of trichosanthes, 30 parts of xiebai, 60 parts of corn silk, 20 parts of plantain, and 30 parts of oyster.

[0011] The second aspect of the present invention provides a use of the above-mentioned traditional Chinese medicine composition in the preparation of a traditional Chinese medicine preparation for preventing and treating atherosclerosis and plaque formation.

[0012] Preferably, the dosage form of the traditional Chinese medicine preparation is decoction or powder.

[0013] A third aspect of the present invention provides a traditional Chinese medicine decoction for preventing and treating atherosclerosis and plaque formation, wherein the traditional Chinese medicine decoction is prepared by the following method:

[0014] (a) weighing the Chinese medicinal components according to weight;

[0015] (b) boiling each Chinese medicinal component in water, filtering, and collecting the filtrate to obtain the Chinese medicinal decoction.

[0016] Preferably, the mass ratio of each traditional Chinese medicine component to water is 1:(3-5).

[0017] Preferably, the decocting step is performed until the volume of the filtrate is 40% to 50% of the volume of the water.

[0018] A fourth aspect of the present invention provides a traditional Chinese medicine powder for preventing and treating atherosclerosis and plaque formation, wherein the traditional Chinese medicine powder is prepared by the following method:

[0019] (a) weighing the Chinese medicinal components according to weight;

[0020] (b) grinding each Chinese medicine component separately, and then mixing the Chinese medicine powders to obtain the Chinese medicine powder.

[0021] Preferably, the pulverization is performed to a particle size of not less than 200 mesh.

[0022] Compared with the prior art, the beneficial effects of the present invention include at least:

[0023] The present invention is aimed at all traditional Chinese medicine believes that "phlegm turbidity" and "blood stasis" are related, and long-term qi stagnation and blood stasis can accelerate vascular diseases; in modern medicine, the mechanisms of thrombosis and plaque rupture of atherosclerosis are similar to the pathology of "blood stasis", and Chinese medicine for promoting blood circulation and removing blood stasis may play a role by improving microcirculation and resisting platelet aggregation; and other related symptoms may also disappear; based on the theory of traditional Chinese medicine, the inventors of this application screened Chinese medicinal raw materials with the effects of promoting blood circulation and removing blood stasis, soothing the liver and regulating qi, resolving phlegm and removing dampness, relieving chest tightness and promoting yang, and strengthening the spleen and replenishing qi. After compounding the raw materials, under their joint action, it has significant therapeutic effect on atherosclerosis and the effect is fast. In addition, the Chinese medicine components of the present invention are all natural ingredients, without any hormone components, are more easily absorbed by the human body, and have significant therapeutic effects. It is a family recipe of traditional Chinese medicine. DETAILED DESCRIPTION

[0024] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the embodiments. The following embodiments are only used to more clearly illustrate the technical solution of the present invention and are therefore only used as examples and cannot be used to limit the scope of protection of the present invention.

[0025] It should be noted that, unless otherwise specified, the technical or scientific terms used in this application should have the common meanings understood by those skilled in the art to which the present invention belongs.

[0026] Example 1

[0027] This embodiment is a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0028] Peach kernel 10g, safflower 7g, angelica 18g, raw rehmannia 25g, chuanxiong 12g, red peony root 10g, chuanxiong 18g, platycodon 12g, bupleurum 12g, stir-fried aurantium 15g, roasted licorice root 8g, ginseng 10g, poria 8g, dried ginger 8g, cyperus rotundus 10g, turmeric 18g, jujube bark 10g, pinellia 18g, tangerine peel 12g, ginger magnolia bark 30g, stir-fried atractylodes 20g, scorpion 4g, centipede 1g, trichosanthes 25g, allium macrostemon 25g, corn silk 70g, plantain 15g, and oyster 35g.

[0029] Example 2

[0030] This embodiment is a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0031] Peach kernel 15g, safflower 12g, angelica 12g, raw rehmannia 15g, chuanxiong 18g, red peony root 15g, chuanxiong 12g, platycodon 18g, bupleurum 18g, stir-fried aurantium with bran 10g, roasted licorice root 4g, ginseng 15g, poria 12g, dried ginger 4g, cyperus rotundus 15g, turmeric 12g, julibrissin bark 15g, pinellia 12g, tangerine peel 18g, ginger magnolia bark 20g, stir-fried atractylodes 30g, scorpion 2g, centipede 3g, trichosanthes 15g, xiebai 35g, corn silk 50g, plantain 25g, and oyster 25g.

[0032] Example 3

[0033] This embodiment is a traditional Chinese medicine composition for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0034] Peach kernel 12g, safflower 9g, angelica 15g, raw rehmannia 20g, chuanxiong 15g, red peony root 12g, Sichuan cyperus 15g, platycodon 15g, bupleurum 15g, stir-fried aurantium with bran 12g, roasted licorice root 6g, ginseng 12g, poria 10g, dried ginger 6g, cyperus rotundus 12g, turmeric 15g, jujube bark 12g, clear pinellia 15g, tangerine peel 15g, ginger magnolia bark 24g, stir-fried atractylodes 24g, scorpion 3g, centipede 2g, trichosanthes 20g, allium macrostemon 30g, corn silk 60g, plantain 20g, and oyster 30g.

[0035] Example 4

[0036] This embodiment is a traditional Chinese medicine decoction for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine decoction is prepared by the following method:

[0037] (a) Weigh the components of the Chinese medicine of Example 1 according to weight;

[0038] (b) boiling each Chinese herbal component in water, filtering, and collecting the filtrate to obtain the Chinese herbal decoction, wherein the mass ratio of each Chinese herbal component to water is 1:3; boiling until the volume of the filtrate is 50% of the volume of the water.

[0039] Example 5

[0040] This embodiment is a traditional Chinese medicine decoction for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine decoction is prepared by the following method:

[0041] (a) Weigh the various Chinese medicinal components of Example 2 according to parts by weight;

[0042] (b) boiling each Chinese herbal component in water, filtering, and collecting the filtrate to obtain the Chinese herbal decoction, wherein the mass ratio of each Chinese herbal component to water is 1:5; boiling until the volume of the filtrate is 40% of the volume of the water.

[0043] Example 6

[0044] This embodiment is a traditional Chinese medicine decoction for preventing and treating atherosclerosis and plaque formation, and the traditional Chinese medicine decoction is prepared by the following method:

[0045] (a) Weigh the various Chinese medicinal components of Example 3 according to parts by weight;

[0046] (b) boiling each Chinese herbal component in water, filtering, and collecting the filtrate to obtain the Chinese herbal decoction, wherein the mass ratio of each Chinese herbal component to water is 1:4; boiling until the volume of the filtrate is 45% of the volume of the water.

[0047] Example 7

[0048] This embodiment is a traditional Chinese medicine powder for preventing and treating atherosclerosis and plaque formation, which is prepared by the following method:

[0049] (a) Weigh the Chinese medicinal components of Example 1 according to weight;

[0050] (b) grinding each Chinese medicine component separately and passing it through a 200-mesh sieve, and then mixing the Chinese medicine powders to obtain the Chinese medicine powder.

[0051] Example 8

[0052] This embodiment is a traditional Chinese medicine powder for preventing and treating atherosclerosis and plaque formation, which is prepared by the following method:

[0053] (a) Weigh the Chinese medicinal components of Example 2 according to weight;

[0054] (b) grinding each Chinese medicine component separately and passing it through a 200-mesh sieve, and then mixing the Chinese medicine powders to obtain the Chinese medicine powder.

[0055] Example 9

[0056] This embodiment is a traditional Chinese medicine powder for preventing and treating atherosclerosis and plaque formation, which is prepared by the following method:

[0057] (a) Weigh the Chinese medicinal components of Example 3 according to weight;

[0058] (b) grinding each Chinese medicine component separately and passing it through a 200-mesh sieve, and then mixing the Chinese medicine powders to obtain the Chinese medicine powder.

[0059] Experimental example

[0060] A Chinese medicinal decoction for preventing and treating atherosclerosis and plaque formation was prepared according to the method of Example 6;

[0061] The above-mentioned Chinese herbal decoction was used to treat a total of 200 patients with atherosclerosis;

[0062] Dosage: Three times a day, 200 ml each time, for 3 months;

[0063] Follow up with each patient and make judgment on the efficacy:

[0064] Cured: symptoms of dizziness, chest tightness and pain disappeared;

[0065] Effective: dizziness, chest tightness or pain symptoms are relieved;

[0066] Ineffective: There was no change in the symptoms of dizziness, chest tightness and pain.

[0067] The statistical results show that 113 patients were cured and 87 patients were effective. It can be seen that the Chinese herbal decoction of the present application has a 100% effectiveness rate for atherosclerosis and a cure rate of 56.5%.

[0068] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and description of the present invention.

Claims

1. A Chinese medicine composition for preventing and treating atherosclerosis and plaque formation, characterized in that: The Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 10-15 parts of peach kernel, 7-12 parts of safflower, 12-18 parts of angelica, 15-25 parts of raw earth, 12-18 parts of chuanxiong, 10-15 parts of red peony root, 12-18 parts of cyperus, 12-18 parts of platycodon, 12-18 parts of bupleurum, 10-15 parts of bran-fried aurantium, 4-8 parts of roasted liquorice, 10-15 parts of ginseng, 8-12 parts of poria, 4-8 parts of dried ginger, 1 part of cyperus. 0-15 parts, 12-18 parts of Curcuma zedoaria, 10-15 parts of Albizzia julibrissin bark, 12-18 parts of Pinellia ternata, 12-18 parts of Citrus aurantium, 20-30 parts of Rhizoma Zingiberis, 20-30 parts of Atractylodes macrocephala with bran, 2-4 parts of Scorpion, 1-3 parts of Scolopendra, 15-25 parts of Trichosanthes, 25-35 parts of Allium macrostemon, 50-70 parts of Corn silk, 15-25 parts of Plantago and 25-35 parts of Oyster.

2. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises the following Chinese medicine components in parts by weight: 12 parts of peach kernel, 9 parts of safflower, 15 parts of angelica, 20 parts of raw rehmannia, 15 parts of chuanxiong, 12 parts of red peony root, 15 parts of cyathula, 15 parts of platycodon, 15 parts of bupleurum, 12 parts of stir-fried aurantium with bran, 6 parts of roasted liquorice root, 12 parts of ginseng, 10 parts of poria, 6 parts of dried ginger, 12 parts of cyperus, 15 parts of turmeric, 12 parts of julibrissin bark, 15 parts of qing pinellia, 15 parts of tangerine peel, 24 parts of ginger magnolia bark, 24 parts of stir-fried atractylodes macrocephala, 3 parts of scorpion, 2 parts of centipede, 20 parts of trichosanthes, 30 parts of xiebai, 60 parts of corn silk, 20 parts of plantain, and 30 parts of oyster.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a Chinese medicine preparation for preventing and treating atherosclerosis and plaque formation.

4. The use according to claim 3, characterized in that The dosage form of the Chinese medicine preparation is decoction or powder.

5. A Chinese medicinal decoction for preventing and treating atherosclerosis and plaque formation, characterized in that: The Chinese medicine decoction is prepared by the following method: (a) Weigh the Chinese medicinal components according to claim 1 or 2 in parts by weight; (b) boiling each Chinese medicinal component in water, filtering, and collecting the filtrate to obtain the Chinese medicinal decoction.

6. The Chinese medicinal decoction according to claim 5, characterized in that The mass ratio of each traditional Chinese medicine component to water is 1:(3-5).

7. The Chinese medicinal decoction according to claim 5, characterized in that The decocting step is performed until the volume of the filtrate is 40% to 50% of the volume of the water.

8. A Chinese medicinal powder for preventing and treating atherosclerosis and plaque formation, characterized in that: The Chinese medicine powder is prepared by the following method: (a) Weigh the Chinese medicinal components according to claim 1 or 2 in parts by weight; (b) grinding each Chinese medicine component separately, and then mixing the Chinese medicine powders to obtain the Chinese medicine powder.

9. The Chinese medicine powder according to claim 8, characterized in that The pulverization is performed to a particle size of not less than 200 meshes.