The application discloses a kind of stable
indometacin tablets and its preparation process, belong to pharmaceutical preparation technical field.The tablet is composed of
indometacin, hydroxypropyl beta-
cyclodextrin, soybean
phospholipid, composite stabilizer, binder and
lubricant, and the composite stabilizer is compounded by succinylated c14-c18
alkyl sulfonate sodium, N-ethyl-L-
glutamine and
maltodextrin according to
specific mass ratio.Preparation process includes
liposome inclusion compound preparation, mixing
granulation,
drying whole particle, total mixing and tabletting.The application realizes the preparation of high
drug loading design, and the composite stabilizer forms a multilayer
coating protection system with hydroxypropyl beta-
cyclodextrin and soybean
phospholipid, which synergistically improves the
dissolution performance and stability of the preparation, makes the
dissolution rate of the preparation fast, and the content of the main component decreases little during long-term storage, solves the problems of low
drug loading, poor stability and
dissolution of existing
indometacin tablets.