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Cercopithecoidealin with anti-tumor function, its preparation and use

An anti-tumor effect and kiwifruit technology, applied in the field of "kiwifruit" and its preparation, can solve unsolved problems and achieve the effects of improving purity, simple production operation and stable process

Inactive Publication Date: 2007-01-17
赵正福
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned patents, macroporous resins are not used for separation, but ethyl acetate is used for extraction. This method brings problems such as equipment, labor prevention, and environmental protection in large-scale industrial production. This method does not solve the preparation of new drug preparations from extracts.

Method used

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  • Cercopithecoidealin with anti-tumor function, its preparation and use
  • Cercopithecoidealin with anti-tumor function, its preparation and use
  • Cercopithecoidealin with anti-tumor function, its preparation and use

Examples

Experimental program
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Effect test

Embodiment 1

[0065] Take 100kg of vine root, add 1200L deionized water, soak for 30 minutes, heat to boil, keep boiling for 3 hours, filter the medicinal liquid; add 1000L deionized water for the second decoction, decoct for 2 hours; decoct for the third time Add 800L of deionized water, decoct for 1 hour; combine the decoction three times, let it stand overnight, filter the supernatant, and concentrate in vacuo to a relative density of 1.08; clarifier chitosan 200g (dissolved in 20L of 1% acetic acid solution), add Extract the concentrated solution with water, stir and let it stand for 12 hours, filter the supernatant, pass it through a 200kg column of D101-I macroporous adsorption resin, flow rate 1L / min, elute with deionized water until colorless, and then use 15% ethanol 200L elution, and 75% ethanol 500L elution, collect 75% ethanol eluate, recover ethanol, concentrate to a relative density of 1.25 (70°C), mix 25kg polyamide, put it into a polyamide column, water and 15% After ethanol...

Embodiment 2

[0067] Take 100kg of vine root, add 1000L deionized water, soak for 45 minutes, heat to boil, keep boiling for 3 hours, filter the medicinal liquid; add 800L deionized water for the second decoction, decoct for 2 hours; decoct for the third time Add 800L of deionized water, decoct for 1 hour; combine three decoctions, let stand overnight, filter the supernatant, and concentrate in vacuum to a relative density of 1.06; clarifier chitosan 500g (dissolved in 50L of 1% acetic acid solution), add Extract the concentrated solution with water, stir and let it stand for 12 hours, filter the supernatant, pass it through a column of HPD300-type macroporous adsorption resin 200kg, flow rate 1.2L / min, elute with deionized water until colorless, and then use 15% acetone 200L elution, and 500L elution with 75% acetone, collect 75% acetone eluent, recover acetone, concentrate to relative density 1.30 (70°C), mix 30kg polyamide, put into polyamide column, water and 15% After elution with acet...

Embodiment 3

[0069] Take 100kg of vine root, add 1000L deionized water, soak for 45 minutes, heat to boil, keep boiling for 3 hours, filter the medicinal liquid; add 800L deionized water for the second decoction, decoct for 2 hours; decoct for the third time Add 800L deionized water, decoct for 1 hour; combine three decoctions, let stand overnight, filter the supernatant, and concentrate in vacuum to a relative density of 1.06; clarifier chitosan 750g (dissolved with 1% acetic acid solution 75L), add Extract the concentrated solution with water, stir and let it stand for 24 hours, filter the supernatant, pass it through a 200kg column of DA201-type macroporous adsorption resin, flow rate 1.0L / min, elute with deionized water until colorless, and then use 15% acetone 200L elution, and 500L elution with 75% acetone, collect 75% acetone eluent, recover acetone, concentrate to relative density 1.30 (70°C), mix 25kg polyamide, put into polyamide column, water and 15% After elution with acetone, ...

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Abstract

An antineoplastic 'actinidine' in the form of coated tablet, capsule, mixture, softgel, particle, injection, or liposome is prepared from the root of lianoid pear through decocting, concentrating, filtering, chromatography with macroreticular resin, eluting by organic solvent, chromatography, concentrating, absorbing by polyamide, eluting and concentrating.

Description

technical field [0001] The present invention relates to the field of herbal medicine and its preparation method and application, in particular to a kind of "actinin" with anti-tumor effect and its preparation method and application. Background technique [0002] The vine pear root described in "Chinese Medicine Identification" is the root of kiwi fruit "Chinese kiwifruit Actinidia chinensis Planch." or kiwi pear "Actinidia arguta (Sieb.et Zucc) Planch." For medicinal purposes, Chinese medicine has the effects of detoxifying, promoting blood circulation, clearing away heat and dampness, and is often used clinically for anti-tumor. Journal of Shaanxi University of Traditional Chinese Medicine (VOL: 28.NO: 3 2005.5), Wei Peifeng et al. "Experimental Study on the Apoptosis of Gastric Cancer Cells Induced by Rattan Pear Root Extract": Using the ethanol extract of Actinidia jujuba to treat gastric cancer cells It has obvious lethal effect. Shaanxi Traditional Chinese Medicine (V...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/7034A61P35/00A61K125/00
Inventor 赵正福
Owner 赵正福
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