The invention relates to preparation of
clathrate compound containing isoflavone and
cyclodextrin of chickpea, comprising the following steps:
grinding the chickpea into
powder,
drying, adding
petroleum ether, backflowing for 1.5 hours in water bath with the temperature of 70 DEG C, filtering and
drying; adding 65%
alcohol, putting the obtained mixture in water bath with the temperature of 85 DEG C, backflowing for 1.5 hours, carrying out backflowing for two times, and filtering; adding
distilled water, pouring the
distilled water into a macroporous absorbing column, adjusting the flow rate to be 1ml / min, using a
beaker to receive samples passing the column; adding 70%
alcohol, adjusting the flow rate to be 0.5ml / min, collecting flow liquid, and distilling to obtain pure flavone; charging
cyclodextrin and pure isoflavone with the
mass ratio of 4-6:1, adding 2-4 times of water under normal temperature,
grinding the mixture to be pasty, vacuum-
drying, cleaning with
alcohol, and drying to obtain the
clathrate compound. The preparation has simple method, low cost, little
toxicity of selected microcapsule wall materials, can increase the
solubility of
botanical drug after clathrate, improve the
bioavailability of isoflavone and has good application prospect.