70 results about "Isovitexin" patented technology

The invention discloses a folium microcotis total flavone extract, and a preparation method and an application thereof. The extract contains 50 wt% to 95wt% of general flavone based on rutin, 3.5 wt% to 7.5 wt% of narcissoside in the total flavone extract, 0.5 wt% to 3.0 wt% of vitexin and 0.5 wt% to 3.0 wt% of isovitexin. The preparation method comprises the steps as follows: coarse extracting; taking one or more of water, methanol and ethanol as an extraction solvent for coarse extracting; refining: taking a macroporous resin or a polyamide or a silica gel as an adsorbent, ethanol or other organic solvents as an eluent for eluting, collecting the eluent, and decompressing and concentrating to obtain the folium microcotis total flavone extract. The folium microcotis total flavone extract provided by the invention contains 50 wt% to 95 wt% of the general flavone based on the rutin, and has the obvious effect of adjusting blood fat. The preparation method is simple and effective, thereby being suitable for industrial mass production and capable of preparing medicines for adjusting the blood fat.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin,β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

The invention provides a method for extracting high-purity vitexin and isovitexin from santati album leaves. The method comprises the steps: repeatedly extracting dried and smashed santati album leaves through ethyl alcohol or methyl alcohol for twice to three times, combining filtrates, decolorizing through a decolorizing agent, performing vacuum concentration and sequentially utilizing petroleumether and ethyl acetate to extract concentrate for twice to three times; combining ethyl acetate extract liquor, concentrating, freeze drying, fully dissolving in water bath and centrifuging to divide into precipitate and supernatant; centrifuging the precipitate in 75 to 85 DEG C water bath and freeze drying the obtained precipitate to obtain the vitexin; concentrating the supernatant and utilizing a cooling crystallization mode to obtain isovitexin. The purity of the vitexin and the isovitexin prepared by the method is higher than 98%; furthermore, the method has the advantages of being simple and convenience in operation, low cost and high extracting efficiency; the obtained product has a high purity, and large-scale production is achieved.

The invention relates to an extraction and purification method of the component with the Chinese herbal medicine functionality, and aims at providing a method of obtaining monomeric compound Vitexin and Isovitexin through extraction and purification from pigeon pea branches and leaves in a simple, safe, economical and high-efficient manner. The invention has the technical proposal of using the fresh and dried pigeon pea branches and the leaves as raw materials, and adopting the combination of a homogenate extraction technique, an ultrasonic assistance extraction technique, an ultrasonic oscillation flocculation technique, a negative pressure cavitation suspension extraction technique, a macropore absorbing resin collecting technique, an ODS-C18 reversed phase medium pressing silicagel column chromatography technique, a low temperature recrystallization and a recrystallization technique, and then the Vitexin and the Isovitexin with the purity of more than 90 percent are obtained, and the extraction rate is more than 0.17 percent and 0.13 percent respectively. The raw material used by the invention is the wasted fresh or dried pigeon pea branches and leaves in the agricultural production, thus the invention cannot damage the ecological balance of plants and affect the agricultural production, and can further get the pigeon pea functionality component. Moreover, the method has the steps of extraction, primary decontaminating and purification, and is simple and practical with little objective compound, thus the method is applicable for the industry application, and has important meaning to the industrialized production.