The invention discloses a cedarane
ketone hydroxy-oxalaxyl ester derivative as well as a preparation method and application thereof, and belongs to the technical field of
agricultural chemistry. The structure of the derivative is shown as a formula I, wherein R is selected from groups shown as E1-E13. According to the invention, safe and non-toxic cedarane
ketone is used as a
raw material, and oximation and esterification reactions are carried out to prepare a target derivative. The series of derivatives show remarkable and broad-spectrum inhibitory activity on various
plant pathogenic fungi, especially
phomopsis kiwifruit, valsa mali,
verticillium dahliae,
mucor and
paecilomyces variotii, and the activity of the
compound E8 is most prominent. The derivative disclosed by the invention can be used as an
active ingredient for preparing a pharmaceutical composition for preventing and treating fungal diseases of plants, and a new choice is provided for developing efficient, low-
toxicity and environment-friendly botanical pesticides.