102 results about "Corpus luteum" patented technology

The invention relates to Chinese herbal medicine feed additive for ewes, which belongs to crashed mixtures and solves the problems that the estrus cycle disorder phenomenon of breeding ewes is more serious, the recessive estrus ratio is high, and the estrus time is dispersive in the prior art. The Chinese herbal medicine feed additive is prepared by crashing and mixing epimedium, motherwort, angelica, Chinese dodder seed, glossy privet fruit, astragalus root and dangshen and can be added into feed for usage. The invention utilizes Chinese herbal medicines to regulate body metabolism functions, has favorable treating effect to uterus inflammations, promotes upgrowth of ovary and uterus, maintains normal estrus cycle, improves symptoms, sexual excitation and upgrowth degree of follicles during ewe estrus, reduces the recessive estrus ratio of ewes, improves follicle quality, shortens estrus duration, forms high-grade corpus luteum, and creates favorable conditions for smooth implantation of fertilization ovum and embryo.

The invention discloses feed for improving production performance of sows. The feed consists of the following components in parts by weight: 400-600 parts of corn flour, 80-150 parts of bran, 100-180 parts of expanded soybean meal, 30-50 parts of fish meal, 180-220 parts of soybean meal, 20-45 parts of soybean oil, 10-20 parts of calcium hydrogen phosphate, 10-20 parts of stone powder, 2-3 parts of lysine, 1-3 parts of methionine, 1-3 parts of threonine, 5-10 parts of compound trace elements, 1-2 parts of compound vitamin, 1-2 parts of oligopeptide, 0.5-1 part of flavone, 1-2 parts of plant extracts, 0.5-1 part of enzyme preparation, 1-2 parts of probiotics and 1-2 parts of feed antistaling agent. The feed provided by the invention can be used for adjusting the endocrine of sow bodies, promoting the development of corpus luteum, activating ovarian function, reducing the incidence of mastitis and endometritis, purifying the reproductive system, delaying the ageing of the reproductive system, improving the production performance of the sows, and increasing the economic benefit of pig raising.

The invention discloses a sow premixed feed for improving the productivity of sows. The sow premixed feed is prepared from the following components in parts by weight: 300-400 parts of puffing soybean flour, 150-250 parts of fish meal, 180-220 parts of bean pulp, 120-150 parts of calcium hydrophosphate, 100-200 parts of mountain flour, 20-30 parts of lysine, 10-30 parts of methionine, 15-35 parts of threonine, 20-30 parts of valine, 60-100 parts of compound trace elements, 12-20 parts of multivitamin, 100-200 parts of oligopeptides, 0.5-1 part of an enzymic preparation, 1-2 parts of probiotics and 1-2 parts of a feed preservative. By virtue of the feed for improving the productivity of the sows disclosed by the invention, the organism endocrine of the sows can be adjusted, the development of corpus luteum is promoted, the ovarian function is activated, the morbidity of mastitis and endometritis is reduced, a reproductive system is purified, the aging of the reproductive system is delayed, and the productivity of the sows is improved. Thus, the economic benefits of pig raising are also improved.

The invention relates to traditional Chinese medicine disciplines, belongs to natural fertilization, not relates to medical ethical problems, and particularly relates to a traditional Chinese medicine compound used for polycystic ovarian syndrome complicating infertility and a preparation method thereof. The compound has the efficacy of soothing liver and regulating Qi, nourishing kidney and enriching Qi, promoting blood flow for regulating menstruation, and regulating endocrine and immunity, is used for polycystic ovarian syndrome complicating infertility of fertile women, and has the advantages of being nutritionally balanced, pure natural, harmless, and free of stimulants, additives, preservatives, and toxic and side effects; a freeze grinding technology is adopted, so that the loss of the effective ingredients of medicine is guaranteed to a maximum extent, and pure natural nutritional ingredients are ensured. Compared with western medicine, the compound has the advantages that a patient has no pain, the treatment cost is economical, the safety is high, and the like; no untoward effect on the patient is found in clinic treatment, the cure rate is high, the treatment course is short, and the compound can replace ovulation induction auxiliary measures or operations, such as ovulation induction and corpus luteum maintenance, of western medicine. According to the compound and the preparation method thereof, through many years of clinical experience, and the treatment and observation for 1210 patients, the total natural fertilization effective rate reaches 95.37%, and the average time to pregnancy is 3.45+/- 0.50 months.

The invention provides a Chinese herbal compound for treating the pubertal polycystic ovary syndrome. The Chinese herbal compound is prepared from, by weight, 30-35 parts of radix astragali, 20-25 parts of American ginseng, 15-20 parts of Radix Salviae Miltiorrhizae,, 15-20 parts of hawthorn, 15-20 parts of poria cocos, 20-25 parts of bighead atractylodes rhizome and 15-20 parts of tangerine peel. The pubertal polycystic ovary syndrome (PCOS) is treated through the method of tonifying qi and spleens, reducing phlegm, activating blood and regulating constitution; compared with other traditional Chinese medicine research, the Chinese herbal compound can reduce levels of luteinizing hormone (LH), luteinizing hormone/follicle-stimulating hormone (LH/FSH), testosterone (T) and androstenedione (AND) in serum of patients and also can reduce the levels of total cholesterol (TC) and apolipoprotein B (APOB) in blood fat, and therefore the aims of regulating the menstrual cycle, improving hyperandrogenism and correcting dyslipidemia are achieved.

The invention mainly relates to fusion protein which is composed of a hormone releasing factor derivative produced through human promoting corpus luteum (GnRH), a lacunae body PE40 or PE38 of pseudomonad exotoxin A, and the mutant thereof which are connected in series, the invention has the key points that the 5, 7, and 8-position amino acid of the N tail end of LHRH is abruptly changed, to ensure the abruptly changed fusion protein to have the stronger tomour cell affinity and distinguishing destruction compared with the known target-oriented fusion protein.

The invention discloses a Chinese medicine preparation for treating primary dysmenorrheal, a preparation method and an application. The Chinese medicine preparation is composed of medicines of angelica, flos rosae rugosae, fennel fruits, ligusticum wallichii, red paenoy roots and the like. On the basis of traditional Chinese medicine syndrome differentiation and treatment theory, the Chinese medicine preparation for treating primary dysmenorrheal is prepared by combining years of clinical experience. The Chinese medicine preparation for treating primary dysmenorrheal is characterized in that according to characteristics of hormonal level change at each stage of a sexual cycle, medicine intervention is performed at the luteal regression stage, two hormone peaks in the whole sexual cycle process can be avoided, relative excited signal molecues at the local position of uterus tissue can be directly confronted, interference for feedback effect on thalamus-hypophysis-ovarian axis sex hormone is weakened, and thereby the effect of treating the primary dysmenorrheal can be exerted. The Chinese medicine preparation for treating the primary dysmenorrheal has special good effects on the diseases of dysmenorrheal and abnormal menstruation and the like caused by kidney energy loss, qi stagnation and blood stasis, congealing cold blood stasis, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach and damp and hot accumulation, the Chinese medicine preparation for treating the primary dysmenorrheal is widely applied to clinic and relieves pains of patients, and the effective rate can reach to 96%.

The invention discloses a medicament for treating ovarian infertility, which is constituted by compound Chinese medicines. The medicine provided by the invention comprises the following medicinal components in weight proportion: epimedium herb 40-120, actinolite 30-100, root of red-rooted salvia 25-100, safflowers 25-100, motherwort herb 30-120, Chinese angelica 30-100, astragalus root 25-120, south dodder seed 30-120, common burreed rhizome 10-60, zedoary root 10-60 and twotooth achyranthes root 20-90. Experiments show that the medicament can be used for treating various diseases, such as hypo-ovarianism (inactive ovary), persistent corpus luteum, ovarian cyst, alternate follicle development, delayed ovulation and the like, and can substitute traditionally applied hormone and antibiotics medicines completely or to certain extent, therefore, the medicament is an important remedial measure indispensable to prevention and treatment of milk cow infertility.

The invention discloses a traditional Chinese medicine for increasing the pregnancy rate of female animals. The traditional Chinese medicine comprises the following raw materials in parts by weight: 140-180 parts of motherwort herb, 25-65 parts of milkvetch root, 60-100 parts of herb of shorthorned epimedium, 60 parts of all-grass of foxtail-like sophora, 85-120 parts of safflower, 160-200 parts of codonopsis pilosula, 160-200 parts of Chinese angelica, 65-105 parts of argy wormwood leaf and 85-125 parts of Chinese dodder seed. According to the traditional Chinese medicine disclosed by the invention, a traditional Chinese medicine prescription is screened out by virtue of repeated research and comparison and all the traditional Chinese medicine raw materials are subjected to fermentation and superfine grinding to prepare the medicine. By virtue of clinical tests, the medicine disclosed by the invention has relatively good curative effects on inactive ovaries and persistent corpus luteum infertility of the female animals as well as postpartum anestrus and repeat breeding infertility of pigs and dogs; and moreover, the traditional Chinese medicine has the advantages of stable and reliable curative effects, no toxic or side effect, convenience in application and simple prescription.

The invention relates to an oocyte in-vitro maturation culture solution and application thereof, and belongs to the technical field of oocyte in-vitro maturation culture solutions. The oocyte in-vitromaturation culture solution and application thereof are provided for solving the problems that it is necessary to add follicular fluid with unclear compositions into the oocyte in-vitro maturation culture solution, and the culture efficiency is not ideal. The culture solution is composed of TCM-199, KSR, penicillin, streptomycin, NaHCO3, Hepes, polyvinyl alcohol, sodium pyruvate, insulin, cysteine, epidermal growth factors, follicle-generating hormones and luteinizing hormones. According to the oocyte in-vitro maturation culture solution, during oocyte in-vitro culture, the similar effects onthe cleavage rate and the blastocyst formation rate can be obtained as a traditional culture solution with added follicular fluid, the disadvantages that in traditional porcine oocyte in-vitro culture, follicular fluid with unknown components needs to be added can be avoided, and thus an oocyte in-vitro maturation system is more standardized.

The invention discloses an application of alpha-ketoglutaric acid to improvement of animal reproduction function deficit caused by high fat diet, and provides a novel application of the alpha-ketoglutaric acid. Abnormity of animal estrus cycle, ovarian morphology and functions and sex hormone secretion caused by high fat diet can be remarkably improved by the alpha-ketoglutaric acid, animal reproduction function deficit caused by high fat diet is further improved, and particularly, estrus cycle disorder, corpus luteum number depletion, theca cell thickness increase, follicle-stimulating hormone content reduction and luteinizing hormone content rise caused by high fat diet are improved by the alpha-ketoglutaric acid, so that animal reproduction function deficit caused by high fat diet can be remarkably improved. Moreover, the alpha-ketoglutaric acid is free from substances harmful to animals or human bodies, adding quantity is small, and the alpha-ketoglutaric acid can be directly added into animal drinking water, feed, food or drugs, has the advantages of safety, effectiveness, no toxic and side effects and the like and has a good popularization and application prospect in improvement of animal reproduction function deficit caused by high fat diet.

The invention relates to a medicine for treating endometriosis, in particular to a Chinese medicine oral decoction for treating endometriosis, which is prepared by using Chinese herbal medicines as raw materials. The invention adopts the technical scheme that the Chinese medicine oral decoction comprises the following raw medicinal materials in parts by weight: 4-12g of bupleurum, 4-12g of salvia miltiorrhiza, 4-12g of achyranthes, 5-15g of red paeony roots, 5-15g of pollen typhae, 5-15g of hemlock parsley, 5-15g of barbary wolfberry fruits, 5-15g of herba epimedii and 5-15g of Chinese dodder seeds. In the invention, all the raw medicinal materials are reasonably mixed to achieve the efficacies of promoting blood circulation and removing blood stasis, clearing heat and detoxicating, relieving stasis and stopping pain, removing heat from the blood and dispersing swelling, calming the mind, relaxing bowel, and the like. By oral administration, the Chinese medicine oral decoction can regulate inner body, strengthen the body resistance to consolidate the constitution, regulate endocrine disturbance, enhance immune functions of human bodies, balance yin and yang, restore the Zang-Fu functions in dynamic balance, and effectively treat endometriosis. The invention has the advantages of no side effect, economy, practicability and simple method, and can be prepared independently. The invention is applicable to patients with slight endometriosis accompanied with luteal insufficiency or ovulation failure.

The invention belongs to the field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for treating infertility caused by ovulation failure. The traditional Chinese medicine preparation mainly comprises a formula capable of invigorating the kidney and replenishing essence, a formula capable of reinforcing the kidney and activating blood, and a formula capableof accelerating corpus luteum, wherein the formula capable of invigorating the kidney and replenishing essence comprises the following raw material ingredients: 15-24 g of radix rehmanniae praeparata,15-30 g of rhizoma dioscoreae, 12-18 g of fructus corni, 15-20 g of fructus lycii, 15-30 g of herba epimedii, 15-30 g of semen cuscutae, 9-12 g of vinegar-processed testudinis carapax, 12-24 g of herba cistanches, 9-12 g of cornu cervi degelatinatum, 12-18 g of radix angelicae sinensis, 9-15 g of parched paeoniae alba radix, 9-15 g of parched atractylodis macrocephalae rhizome and 6-12 g of endothelium corneum gigeriae galli. According to a rule of mutual transformation between yin and yang as well as qi and blood replenishment and deficiency change during each period of menstruation, follicle development and ovulation can be accelerated, the ovulation rate and the pregnancy rate of the anovulatory infertility can be improved, a clinical curative effect is exact, a pregnancy rate is high,and an ovulation failure problem is solved fundamentally.

The invention relates to shaping combined underwear in combination with the menstrual cycle of women and a wearing method of the shaping combined underwear. The shaping combined underwear is formed by combining an upper garment part and a trouser part, and is characterized in that the four structural forms of the upper garment part and the trouser part are provided according to the menstrual cycle of women and include a pressure-free structure, a medium-pressure structure, a heavy-pressure structure and a light-pressure structure. According to the pressure-free structure, the upper garment part and the trouser part are of separate and independent structures or connected into a whole through a hanging belt, and the underwear of the pressure-free structure is suitable for being worn during the menstrual period. According to the medium-pressure structure, the upper garment part and the trouser part are of a connected structure or of separate and independent structures, and the underwear of the medium-pressure structure is suitable for being worn during the follicular period. According to the heavy-pressure structure, the upper garment part and the trouser part are of separate and independent structures or connected into a whole through the hanging belt, and the underwear of the heavy-pressure structure is suitable for being worn during conditioning period namely the corpus luteum former period. According to the light-pressure structure, the upper garment part and the trouser part are of a connected structure, and the underwear of the light-pressure structure is suitable for being worn during the corpus luteum later period. The shaping combined underwear has the functions of emphasis caring and special shaping functions, and has the advantages of not only protecting the health of women, but also easily shaping the body line and the like.

The present invention pertains to the art of Chinese medicine products and provides a Chinese medicine for treating female barrenness due to the suppression of ovulation, mainly comprising ginseng, hominis placenta, angelica, codonopsis pilosula, wolfberry and epimedium. After being prepared, the combination synergy effect of all the drugs can adjust female endocrine disorders, improve body immunity and luteal function, facilitate follicle formation, eliminate polycystic ovary, prevent more follicles ovulation, optimize the fertilized egg in the innate and avoid the occurrence of abortion and fetal malformation. Compared with a traditional method, the invention treats both symptom and root cause of the disease, improves ovulation rate, pregnancy rate and fertility rate, has no side effect and protects female health.

The invention discloses a method for synchronizing oestrus of Nubian goats, which comprises the following steps of manufacturing artificial corpus luteum, combining the artificial corpus luteum with corpus luteum in vivo to inhibit the follicular development of an ewe, eliminating the artificial corpus luteum by removing a suppository, and injecting the cloprostenol with a specific dosage to dissolve the corpus luteum in vivo to promote the development, maturation and ovulation of the follicle. According to the method for synchronizing oestrus of the Nubian goats, the estrus, mating, pregnancyand delivery of the animal population are adjusted to be carried out simultaneously within a certain time, the industrialized and assembly line management cultivation of the lactation period, the reserve period and the fattening period is unified, and the scientific feeding management of the descendants is well carried out. The method for synchronizing oestrus of the Nubian goats aims to fill inthe blank in the prior art for treating the synchronous oestrus of the Nubian goats, and provides a set of concrete implementation method, medicament and dosage of the technology for treating the synchronous oestrus of the Nubian goats.

The invention relates to a method for improving bovine oocyte maturation in vitro. Particularly, the method for improving bovine oocyte maturation in vitro comprises the following steps: (1) providing oocytes; and (2) maturation of oocytes in vitro: putting the occytes in mature culture solution to perform maturation cultivation in vitro for 22-24 h under culture conditions of 100% humidity, 38.5DEG C and 5% CO2. The mature culture solution comprises: ECS, NaHCO3, EGCG, Hepe, estradiol, BFF, luteinizing hormone (LH), cysteine, follicle stimulating hormone (FSH) and TCM-199. The method for improving bovine oocyte maturation in vitro can effectively promote performance of bovine occyte maturation in vitro.

The invention relates to a traditional Chinese medicinal composition for treating gynaecologic barrenness, wherein the drink is prepared from the following raw materials (by weight portion): safflower 10-15 parts, tortoise shell 7-10 parts, turtle shell 7-10 parts, myrrh 4-6 parts, rheum officinale 10-12 parts, burred tuber 10-15 parts, Chinese angelica root 10-15 parts, and cyathula root 8-15 parts.

The invention relates to application of clomifene citrate to anti-mycobacterium tuberculosis medicines. Clomifene citrate has estrogenic and antiestrogenic properties that appear to prevent the release of gonadotropins, follicle-stimulating hormone and luteinizing hormone, thus leading to follicular development and maturation, ovulation and subsequent corpus luteum development and function and then resulting in pregnancy. It is found through researches that the clomifene citrate has an antitubercular effect and has good development value. The application of the clomifene citrate to anti-mycobacterium tuberculosis medicines and the obvious anti-mycobacterium tuberculosis effect of the clomifene citrate are disclosed for the first time.

The invention belongs to the technical field of embryo transplantation and relates to a control method for synchronization of menstrual cycles of a donor mare and a receptor mare. The control method comprises the steps of respectively examining the donor mare and the receptor mare more than once every day, and recording dynamic information of oestrus states, follicle growth states and ovulation time; making a form for the dynamic information to track, observe and record menstrual cycle information of the maria; using prostaglandin on the donor mare and the receptor mare to enable the maria to be in oestrum according to difference with the dynamic information; measuring the diameters of follicles according to the dynamic information and images after the maria are in oestrum; finally utilizing human chorionic gonadotropin to promote ovulation and generate corpus luteum according to physiological difference; and achieving synchronization of menstrual cycles of the donor mare and the receptor mare. The control method is simple in principle, easily controllable in process, accurate in control, high in efficiency and good in effect.

The invention discloses a traditional Chinese medicine composition for treating ovulation failure. The traditional Chinese medicine composition is prepared from the following raw materials of 10-20 parts of astragalus membranaceus, 10-20 parts of raspberries, 5-10 parts of sichuan lovage rhizomes, 10-15 parts of rhizoma polygonati praeparata, 10-20 parts of radix salviae miltiorrhizae, 2-4 parts of herba moslae, 3-6 parts of peach kernels, 8-10 parts of cinnamon, 10-20 parts of radix angelicae sinensis, 10-20 parts of radix paeoniae alba, 5-10 parts of radix rehmanniae preparata, 9-15 parts ofherba epimedii, 5-10 parts of desertliving cistanche, 5-8 parts of grassleaf sweetflag rhizomes, 5-10 parts of radix asparagi, 9-15 parts of mulberries, 5-10 parts of nutgrass galingale rhizomes, and10-15 parts of stir-baked yams. Based on the effect of nourishing the kidney, the traditional Chinese medicine composition has the efficacy of soothing the liver, invigorating the spleen, tranquilizing mind, promoting the circulation of qi, promoting blood circulation and the like, has effect of being similar to endocrine hormone, can effectively regulate the female endocrine, can improve the immunity of organisms, can increase the corpus luteum functions, can promote effective generation of ovarian follicles, can treat both manifestation and root cause of disease, can increase the ovulationrate, the pregnancy rate and the fertility, and is free from side effects.

The invention discloses a traditional Chinese medicine formula for treating cow infertility. The traditional Chinese medicine formula comprises the following components in parts by weight: 80 to 120 parts of herba epimedii, 40 to 60 parts of angelica sinensis, 45 to 60 parts of fructus psoraleae, 45 to 60 parts of radix rehmanniae preparata, 50 to 60 parts of red peony root, 50 to 60 parts of onion and garlic seeds, 46 to 60 parts of fructus lycii, 45 to 60 parts of rhizoma cyperi, 90 to 110 parts of herba leonuri, 40 to 50 parts of curculigo orchioides, 40 to 50 parts of fructus cnidii and 40 to 50 parts of morinda officinalis. According to the traditional Chinese medicine formula provided by the invention, traditional Chinese medicine capable of reinforcing kidney to strengthen yang, promoting blood circulation to remove meridian obstruction, and removing blood stasis for promoting tissue regeneration is adopted to form prescriptions, which can adjust the inherent adjusting ability of organisms and promote the recovery of sexual function. Therefore, the traditional Chinese medicine formula has an obvious curative effect to ovarian quiescence and persistent corpus luteum infertility of postpartum cows.