69 results about "Succinates" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid dispersion-based sustained-release drug composite carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out synergistic spray drying on double polymers (hydroxypropyl methylcellulose acetate succinate and polyvinylpyrrolidone-vinyl acetate copolymer) to form a solid dispersion; compounding with mesoporous silica and calcium silicate for localization, and spraying ethanol to activate pores; calcium stearate and magnesium stearate are sequentially added for lubrication; prefabricating a sustained-release skeleton master batch; and finally, mixing, rolling and forming. According to the method, through hierarchical structural design, the drug stability, the powder fluidity and the release controllability are remarkably improved, the method is suitable for industrial production of the dihydroergoline mesylate sustained release preparation, and a release curve is smooth and reliable.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

This disclosure provides formulations and processes that reduce the injection molding cycle times for poly(hydroxyalkanoate) blends which may contain a succinate polymer such as poly(butylene succinate), a filler such as lignocellulosic biomass and other additives. Blending of PHA with the second polymer may increase biodegradability and compostability.

The invention belongs to the field of hydraulic transmission materials, and provides a preparation method of biodegradable water-ethylene glycol flame-retardant hydraulic fluid. According to the invention, a core-shell micelle structure with a volume median particle size of 80 to 200 nanometers is constructed by adopting a collaborative design of an A1 succinate micelle intermediate and a B1 fatty acid alcohol amine salt anti-wear and anti-rust agent; the performance combination that the kinematic viscosity at 40 DEG C is 36-60 square millimeters per second, the viscosity index is larger than or equal to 140, and the pH value is 8.0-9.5 is achieved, the contradiction between low-temperature fluidity and high viscosity index, between nano-micelle stability and high-pressure abrasion resistance and rust resistance, and between long-term chemical stability and high biodegradability of a traditional water-ethylene glycol hydraulic medium is solved, and the water-ethylene glycol hydraulic medium is suitable for large-scale production. The 28-day biodegradation rate is larger than or equal to 60%, and the lubricating oil has the advantages of being flame-retardant, environmentally friendly and excellent in anti-wear and anti-rust performance, is suitable for a hydraulic system with the rated pressure ranging from 5 MPa to 35 MPa, and has the wide application value.

This invention relates to the field of galvanized steel wire technology, and proposes a high-strength galvanized steel wire and its preparation method. The preparation method of high-strength galvanized steel wire includes the following steps: activating the steel wire, then subjecting it to fluxing to obtain a pretreated steel wire; hot-dip galvanizing the pretreated steel wire, followed by passivation, to obtain high-strength galvanized steel wire; during fluxing, the flux consists of the following components by mass percentage: 20%~25% zinc chloride, 16%~20% ammonium chloride, 1.0%~2.0% additives, 1%~2% nickel chloride, 1%~2% lanthanum nitrate, 0.2%~0.5% ammonium bifluoride, with the balance being water; the additives are palmitamide propyl betaine and disodium lauryl sulfosuccinate. Through the above technical solution, the problem of insufficient wear resistance of galvanized steel wire in related technologies is solved.

This invention provides a continuous method for preparing vitamin E succinate polyethylene glycol ester (TPGS). It uses a strongly acidic cation exchange resin (such as the Amberlyst series) or a perfluorosulfonic acid resin (such as the Nafion series) as a heterogeneous catalyst, which is packed in a fixed bed to catalyze the esterification reaction between vitamin E succinate and polyethylene glycol. This method achieves precise proportioning of reactants, instantaneous mixing, isothermal reaction, and online dehydration, reducing the reaction time from several hours required by existing batch methods to tens of minutes. It allows for long-term stable use, requires no complex post-processing, and produces products with high yield, good purity, and light color. The preparation method of this invention solves the problems of difficult catalyst recovery, excessive waste, low efficiency, and unstable product quality in existing methods, making it particularly suitable for large-scale, continuous, and green production of TPGS.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

An agrochemical concentrate comprises lecithin and at least one agrochemical active. The agrochemical concentrate may also comprise a dispersant selected from sucrose ester, alkylpolyglucoside, alkylnaphthalene sulphonates, phosphate ester, sorbitol ester, polyglycerol ester, alkyl sulphates, sodium lauryl sulphate, alkylglucamides, and dialkyl sulphosuccinates. An aqueous formulation comprises a dilution of the agrochemical concentrate in an electrolyte. A pre-blend comprises lecithin and a dispersant. A method of preparing the agrochemical concentrate and a method for treating vegetation are also disclosed.

The invention relates to the technical field of bioenergy active hydrogel, in particular to silk fibroin hydrogel with bioenergy activity and a preparation method of the silk fibroin hydrogel. The preparation method comprises the following steps: carrying out esterification reaction on a silk fibroin solution containing hydroxyl and phenolic hydroxyl and succinic anhydride to obtain succinic acid esterified silk fibroin; carrying out dissolution promoting treatment on the succinic acid esterified silk fibroin to obtain gel precursor liquid; a hydrogen peroxide solution of horse radish peroxidase and the gel precursor fluid are subjected to a cross-linking reaction, and the silk fibroin hydrogel containing succinic acid esterified silk fibroin is obtained. According to the preparation method, firstly, a silk fibroin solution and succinic anhydride are subjected to an esterification reaction, then horse radish peroxidase and a hydrogen peroxide solution are subjected to a cross-linking reaction, a stable hydrogel structure is formed, and the gel can improve the energy metabolism level of intervertebral disc cells.

The invention relates to the technical field of bauxite flotation desiliconization, and particularly discloses a desiliconization agent for bauxite beneficiation and a preparation method of the desiliconization agent. The desiliconizing agent is prepared by taking a modified carboxylic acid copolymer as a main collecting agent and matching with sulfonated succinate, sodium lignin sulfonate, a function regulator, a cationic additive and a pH regulator. According to the agent, selective collection of silicon minerals is enhanced through multi-component cooperation, the desilicication rate exceeds 90%, the aluminum recovery rate exceeds 85%, the dosage is only 320-350 g / t, and the agent is suitable for various bauxite types, easy and convenient to prepare and easy to industrialize.

A catalyst component for olefin polymerization, a preparation method therefor and a use thereof are provided. The catalyst component contains elemental magnesium, elemental titanium and an internal electron donor. The internal electron donor has a phosphate ester, and an α-cyanosuccinate and / or a substituted α-cyanosuccinate. A molar ratio of the phosphate ester to the elemental magnesium is 0.0002-0.002:1. When the catalyst is used for olefin polymerization, especially for propylene polymerization, the obtained polymer has the characteristics of a high Z+1 average molecular weight and a good balance of rigidity and toughness.

The invention belongs to the technical field of preparation of drug carriers, and particularly provides a nano-micelle for embedding curcumin as well as a preparation method and application of the nano-micelle. The preparation method of the nano-micelle for embedding curcumin comprises the following steps: dissolving shellac, PGPR, beta-sitosterol succinate and curcumin in liquid coconut oil, and adding ethanol to form an organic phase; and after mixing with a xanthan gum aqueous solution, carrying out pre-emulsification, fine emulsification, gradient cooling and cold storage curing to obtain the nano-micelle. The encapsulation efficiency of the nano-micelle is greater than or equal to 93%, the drug loading capacity reaches 1.58%-4.15%, and the nano-micelle has efficient pH response targeting property; wherein the beta-sitosterol succinate enhances the drug-loading core density, the shellac constructs a gastric juice barrier, and the PGPR maintains the micelle dispersibility, so that the oral bioavailability of the curcumin can be improved by 46-55 times compared with that of free curcumin, and the curcumin is suitable for efficient delivery of food functional components or drugs.

The invention provides a preparation method of an adhesive for an excrement storage bag capable of being smeared, and belongs to the field of preparation of adhesives for excrement storage bags. The method comprises the following steps: dissolving a mixture A in anhydrous dichloromethane, carrying out a stirring reaction under the protection of inert gas, and sequentially carrying out hydrochloric acid washing, saturated saline solution washing, rotary evaporation concentration and diethyl ether precipitation to obtain two-arm polyethylene glycol allyl succinate; wherein the mixture A is prepared from the following components in parts by weight: 20 to 40 parts of two-arm type polyethylene glycol, 1 to 2 parts of allyl succinic anhydride and 1 to 2 parts of dimethylaminopyridine. The prepared adhesive can be smeared on the surface of any uneven skin around the stoma, and the adhesive can generate viscosity through ultraviolet irradiation, so that an excrement storage bag is tightly adhered to the skin, excrement leakage is prevented, and tissues around the stoma are protected. And the adhesive can be easily eluted by using medical alcohol, so that the excrement storage bag is convenient to replace. The used materials are simple and easy to obtain, the operation is simple, the price is low, and good news is brought to vast stoma patients.

This invention relates to the field of oilfield development technology and discloses a modified nano-displacement agent and its application in oil well production enhancement. The agent comprises 5.0–10.0 wt% succinate gemini polyoxyethylene ether, 3.0–5.0 wt% erucamide propyl hydroxysulfonate betaine, 10.0–20.0 wt% polyether-modified silicone oil, 1.0–3.0 wt% sodium xylenesulfonate, 1.0–2.0 wt% 1,2-propanediol, and 60.0–80.0 wt% deionized water. During preparation, a phase-conditioning fluid is added via high-shear emulsification combined with a cooling jet to obtain a nanoscale dispersion system. This invention utilizes the combination of gemini surfactant and betaine to improve phase stability under high temperature and high salinity conditions and effectively reduce interfacial tension; the steric hindrance of the modified silicone oil reduces formation adsorption losses; and the nanoscale droplets can penetrate deep into the micro- and nano-pore throats of low-permeability formations to strip crude oil, alleviating injection difficulties and synergistically achieving increased oil well production.

The present invention relates to the use of octenyl succinate starch, in particular sodium octenyl succinate starch as a binder in wet granulation, in particular for pharmaceutical solid dosage form and the granule obtainable by the method thereof.

The present invention relates to sulfate-free aqueous personal care composition comprising from about 0.2 pbw to about 15 pbw of a derivatized cationic guar comprising cationic substituent groups and non ionic substituent groups, at least 0.05 pbw of an oil and from about 2 pbw to about 20 pbw of a surfactant system comprising at least one lauramphoacetate, and one sulfosuccinate. It is also directed toward the use of such a composition for washing keratin substrates, in particular the hair or the scalp.

The present invention provides a process for producing dialkyl succinates, comprising hydrogenating dialkyl maleate in a multi-stage process comprising at least two hydrogenation stages, wherein in a first hydrogenation stage, a feed stream comprising dialkyl maleate is exposed to hydrogenation conditions over a catalyst at a temperature T1 to produce a first stream comprising dialkyl succinate and unsaturated compounds, and in a second hydrogenation stage, the first stream is exposed to hydrogenation conditions at a temperature T2 to produce a second stream comprising dialkyl succinate and a lower concentration of unsaturated compounds than the first stream, wherein T2 is less than T1.

The present invention provides a resin composition exhibiting excellent adhesion and reliability, a display device including an adhesive member made from the resin composition, and a method for manufacturing the same. [Solution] The resin composition contains 5 wt% to 10 wt% of 2-acryloyloxyethyl succinate and 5 wt% to 10 wt% of 4-hydroxybutyl acrylate, based on the total weight of the resin composition.

The invention discloses a preparation method of a water-based succinic anhydride derivative anti-corrosion lubricant and application of the water-based succinic anhydride derivative anti-corrosion lubricant in protecting aluminum and / or aluminum alloy from corrosion, and application of the water-based succinic anhydride derivative anti-corrosion lubricant in providing lubrication in the metal processing process, and the preparation method comprises the following steps: under the protection of inert gas, maintaining the micro-positive pressure to be 500-2000Pa, and under the condition of 60-120 DEG C and no solvent, adding the water-based succinic anhydride derivative anti-corrosion lubricant into the lubricant, at least one saturated alkyl succinic anhydride and at least one mercapto polyethylene glycol monomethyl ether are subjected to an esterification reaction according to the molar ratio of 1: (0.8-1.5), and the reaction endpoint is that the acid value of a reactant does not change any more, so that the succinate compound is obtained; wherein the saturated alkyl succinic anhydride is selected from one or more of straight-chain or branched-chain octyl succinic anhydride, nonyl succinic anhydride, decyl succinic anhydride, dodecyl succinic anhydride, tetradecyl succinic anhydride, hexadecyl succinic anhydride or octadecyl succinic anhydride; the mercapto polyethylene glycol monomethyl ether has a structural formula of CH3 (OCH2CH2) nSH, wherein n is an integer from 2 to 20.

The invention discloses a special antioxidant composition for rice bran oil as well as a preparation method and application thereof, and relates to the technical field of oil oxidation resistance. The special antioxidant composition for the rice bran oil comprises the following components: ferulate, ascorbyl palmitate, a VE (Vitamin E) derivative and a composite auxiliary material, the VE derivative is selected from VE acetate and / or VE succinate; the composite auxiliary material is selected from citric acid and / or disodium EDTA (Ethylene Diamine Tetraacetic Acid). According to the special anti-oxidation composition for the rice bran oil as well as the preparation method and the application of the special anti-oxidation composition, the ferulate, the ascorbyl palmitate and the VE derivative are compounded, so that the oxidation pain point of the rice bran oil is solved in a targeted manner, the chelating rate of metal ions in the rice bran oil reaches 85% or above, the scavenging rate of peroxy free radicals reaches 93%, and the normal-temperature shelf life of the rice bran oil is prolonged from 60 days to 360 days or above.

A method for synthesizing an aluminium-fluoride complex obtainable by reacting together: a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; or a chelate bearing molecule precomplexed with aluminium(III), obtained from treating the chelate bearing molecule with a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; the fluoride being [19F]fluoride or radioactive [18F]fluoride; wherein the counterions of aluminium(III) other than chloride are selected from bromide, iodide, nitrate, phosphate, sulfate, sulphonate, hydroxide, any anionic salt of natural and non-natural amino acids, 2,4-pentanedionate, 8-hydroxyquinoline, acetate, acrylate, ascorbate, aspartate, benzenesulfonate, benzoate, besylate, bitartrate, camphorsulfonate, citrate, decanoate, esylate, fumarate, gentisate, gluconate, glutamate, glutarate, glycinate dihydroxide, glycolate, hexanoate, hydroxynaphthoate, isethionate, lactate, lactobionate, malate, maleate, malonate, mandelate, mesylate, methylsulfate, methylsulfonate, mucate, napsylate, octanoate, oleate, oxalate, pamoate, pantothenate, phthalate, polygalacturonate, propionate, salicylate, stearate, succinate, tartrate, teoclate, toluenesulfonate, trifluoroacetate, trifluoromethanesulfonate, and any combination thereof.

This invention discloses a method for preparing sodium sulfosuccinate using alkyl glycoside catalysis and its application, belonging to the field of surfactant synthesis technology. This method, for the first time, proposes using C8-C14 alkyl glucoside as a catalyst to catalyze the esterification of maleic anhydride with C8-C18 fatty alcohols in an anhydrous system at 60-100℃ and pH=5.0-7.0, followed by sulfonation with sodium sulfite to obtain the target product. The catalyst can be recovered through phase separation with saturated brine, and its activity remains ≥85% after 5 cycles. This invention solves the problems of equipment corrosion, high color, and high levels of waste gas, wastewater, and solid waste associated with traditional processes. Equipment corrosion rate is reduced to 0, product color is ≤25 Hazen, wastewater COD is reduced by more than 96%, and the cost of catalyst per use is reduced by 81%. The product exhibits excellent surface activity and can be widely used in the preparation of personal care and cosmetic products.

The invention relates to a supramolecular gel lubricant and a preparation method thereof. The supramolecular gel lubricant comprises base oil and a gelator, the gelator is a compound formed by sodium 2-ethylhexyl sulfosuccinate and a fluorine-containing gelator, and the fluorine-containing gelator is a compound formed by the sodium 2-ethylhexyl sulfosuccinate and the fluorine-containing gelator. The fluorine-containing gelator has a structural formula shown in the specification. The invention creatively designs and synthesizes a fluorine-containing amide derivative with rosin as a skeleton. A rigid hydrophenanthrene ring of rosin provides strong space support and pi-pi accumulation effects, an introduced amide group can form a strong ionic bond with sulfonate radicals of AOT, and a perfluorooctyl chain shows good self-repairing performance through fluorine-fluorine interaction and excellent compatibility with perfluoropolyether base oil, so that the perfluorooctyl chain has good self-repairing performance. The friction coefficient and the wear volume are obviously reduced.

A two-step method for preparation of a colloidal functionalized blue-emitting quantum dots, comprising following steps: stabilizing ligand exchange comprising functionalization of the QDs surface with 2-ethyl-1-hexanethiol and ligand exchanging 2-ethyl-1-hexanethiol into mono-2-(methacryloyloxy)ethyl succinate. A preparation method of UV-curable ink, a composition of UV-curable ink, a use of the UV-curable ink and a light-emitting device.

The lubricant composition comprises graphite, an oil, and a dispersant selected from the group consisting of a sulfosuccinate, a polyalkylene glycol comprising propylene oxide and butylene oxide, and combinations thereof, wherein the combination of sulfosuccinate dispersant and polyalkylene glycol dispersant comprises up to 80 wt.% polyalkylene glycol, based on the total weight of the combined sulfosuccinate and polyalkylene glycol dispersants.

The invention discloses a composite food composition capable of dispelling effects of alcohol and protecting liver and a preparation process of the composite food composition in the field of functional food. The composition comprises freeze-dried natto powder, a kudzuvine root extract, a hovenia dulcis thunb extract, corn oligopeptide, glutathione yeast powder, dihydroquercetin, soybean oligopeptide, turmeric and two specific modified compounds, namely quercetin-3-O-lactate and curcumin monosuccinate. The modified compound is prepared by a mild and controllable chemical modification method, quercetin-3-O-lactate is synthesized at room temperature by a carbodiimide method, curcumin monosuccinate is prepared by reaction of curcumin and succinic anhydride in a low-temperature anhydrous pyridine system, and post-treatment conditions are strictly controlled to guarantee the stability and purity of the product. All the components are mixed and then subjected to dry granulation to obtain a finished product. The composition synergistically exerts the effects of accelerating alcohol metabolism, relieving liver injury and resisting oxidation, and has good effects of dispelling the effects of alcohol and protecting liver and edible safety.

The present invention provides a pesticidal solid composition having improved compatibility with a system containing a cationic adjuvant. The pesticidal solid composition comprises at least one pesticidal compound in a concentration from 20% to 90% w / w and at least one anionic compound in a concentration from 1% to 20% w / w, wherein the anionic compound is selected from the group comprising a naphthalene sulfonate formaldehyde condensate, optionally alkyl substituted, alkyl sulfosuccinate or a salt thereof or a mixture thereof, and an agriculturally acceptable excipient.

The present disclosure provides formulations such as, for example, sun care formulations, hair care formulations, skin care formulations, and makeup formulations, comprising diisoamyl succinate. The present disclosure also provides methods of making such formulations and methods of using such formulations.

This application discloses a coating powder for non-fried foods and its application, belonging to the field of food processing technology. The coating powder composition for non-fried foods comprises the following components: Component A: a low cold water swelling base starch, wherein the cold water swelling base starch has a swelling degree of 1.2–4.0 and does not include oxidized starch, and comprises 15–35 parts by weight of the total weight of the coating powder composition; Component B: a medium-high cold water swelling α-starch, wherein the cold water swelling degree of the medium-high cold water swelling α-starch is 5–25, and comprises 8–20 parts by weight of the total weight of the coating powder composition; Component C: octenyl succinate starch, comprising 5–20 parts by weight of the total weight of the coating powder composition; Component D: a texture-improving material, comprising 15–35 parts by weight of the total weight of the coating powder composition; wherein the total content of components A, B, and C comprises 35–65 parts by weight of the total weight of the coating powder composition.