116 results about "Succinates" patented technology

The present invention relates to a dispersant for graphite and graphene and its application. The composition is a synergistic combination of alkyl sulfosuccinate and polyalkylene glycol. Appropriate adding amount thereof can quickly and easily disperse graphite and graphene in the medium, improve its dispersion uniformity and stability, delay its sedimentation, and inhibit its re-accumulation. Furthermore, the present invention can apply graphite and graphene to other media besides non-water-based or organic solvents. The composition of the present invention does not contain flammable volatile chemicals, any fluorine-, silicon- or phosphorus-based compounds, or any aromatic substances. The present invention can not only reduce environmental pollution but also improve the operational safety of relevant personnel.

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid dispersion-based sustained-release drug composite carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out synergistic spray drying on double polymers (hydroxypropyl methylcellulose acetate succinate and polyvinylpyrrolidone-vinyl acetate copolymer) to form a solid dispersion; compounding with mesoporous silica and calcium silicate for localization, and spraying ethanol to activate pores; calcium stearate and magnesium stearate are sequentially added for lubrication; prefabricating a sustained-release skeleton master batch; and finally, mixing, rolling and forming. According to the method, through hierarchical structural design, the drug stability, the powder fluidity and the release controllability are remarkably improved, the method is suitable for industrial production of the dihydroergoline mesylate sustained release preparation, and a release curve is smooth and reliable.

The invention relates to the technical field of surfactants, and particularly discloses a preparation method and application of a sulfosuccinate type surfactant, and the preparation method specifically comprises the following steps: (1) esterification reaction: under the protection of inert gas, adding fatty alcohol and carboxylic acid anhydride, introducing gas for 10-20 minutes, adding a difunctional acidic site catalyst, heating to 95-105 DEG C, and reacting for 2-3 hours to obtain an esterification product; and (2) sulfonation reaction: cooling the esterification product to 70-80 DEG C, dropwise adding 20-40wt% of sulfonating agent aqueous solution, preserving heat for 1-2 hours after dropwise adding, and then performing post-treatment to obtain the sulfosuccinate type surfactant. In the preparation process, one-pot preparation is realized by regulating and controlling process conditions and developing a catalyst to efficiently catalyze esterification and sulfonation, intermediate products do not need to be separated between esterification and sulfonation, material loss caused by transfer and separation is avoided, the adopted catalyst can be used for inhibiting premature oxidation of a sulfur source in the sulfonation process, and the sulfonation efficiency is improved. The generation of byproducts is reduced, and the yield is improved.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

The present invention discloses a method for improving the liposome encapsulation efficiency by modifying a cholesterol composite prodrug. Specifically, the drug curcumin and vitamin E succinate are first reacted with cholesterol to obtain a cholesterol-curcumin complex and a cholesterol-vitamin E succinate complex. The two obtained complexes are then uniformly mixed with a lipid and then prepared by thin film hydration to obtain drug-loaded liposomes. The present invention utilizes the cholesterol composite prodrug method to improve the low solubility of curcumin and vitamin E succinate in liposomes, improve the encapsulation efficiency of the two drugs in liposomes, and provide a new approach for the preparation of liposomes containing poorly soluble compounds.

The invention discloses a preparation method of walnut protein isolate, and the walnut protein isolate prepared by the method has the efficacy of improving dysmnesia of old people and can be used for preparing acidic food, emulsified food and foam food. According to the method disclosed by the invention, the high-quality walnut protein isolate is prepared by taking degreased walnut powder as a raw material and utilizing the principles of reverse micelle dissolution, isoelectric precipitation and high solubility of bis (2-ethylhexyl) sodium sulfosuccinate in ethanol. The walnut protein isolate prepared by the invention has the advantages of high apparent property, high protein content, strong solubility, strong emulsifying ability, strong foaming ability, high in-vitro old-age model digestibility and AChE inhibition ability and antioxidant ability of strong digestion products.

The invention belongs to the technical field of lubricating oil, and particularly relates to an internal combustion engine oil composite additive and a preparation method and application thereof. The internal combustion engine oil composite additive is prepared from the following raw materials in percentage by mass: 5 to 25 percent of sulfonate, 5 to 12.5 percent of an oxidation and corrosion inhibitor, 5 to 12.5 percent of an anti-wear agent, 5 to 10 percent of an antioxidant, 1 to 2.5 percent of heptadecenyl imidazoline succinate, 0.5 to 1 percent of a nano compound and the balance of a dispersing agent, the nano compound is a compound of nano molybdenum carbide and nano aluminum oxide. Lubricating oil adopting the internal combustion engine oil composite additive has good wear resistance, water resistance and corrosion resistance, meanwhile, good low-temperature fluidity and low loss, oxidative deterioration of engine oil and generation of sediments can be effectively inhibited, the low-speed preignition frequency of an engine can be reduced, and the service life of the engine oil is prolonged. Timing chain abrasion protection and valve system abrasion protection are provided for an engine.

This disclosure provides formulations and processes that reduce the injection molding cycle times for poly(hydroxyalkanoate) blends which may contain a succinate polymer such as poly(butylene succinate), a filler such as lignocellulosic biomass and other additives. Blending of PHA with the second polymer may increase biodegradability and compostability.

The present invention provides a method for cleaning an object surface, the method having enzyme activity even if using high concentrations of surfactants and an enzyme together, and exhibiting excellent cleaning performance for solid fat-containing contamination adhering to the object surface of tableware or the like without being affected by the hardness of water used for cleaning (for example, 0 to 20° dH (by German hardness)).A method for cleaning an object surface including, bringing a cleaning liquid obtained by diluting a liquid cleaning agent composition with water into contact with the object surface, the liquid cleaning agent composition containing the following component (a), component (b); component (c) and component (e) and water,component (a): an alkyl sulfosuccinic acid ester or a salt thereof,component (b): one or more surfactants selected from a semipolar surfactant and an amphoteric surfactant,component (c): a nonionic surfactant, andcomponent (e): an enzyme.

The invention belongs to the technical field of high-foaming agents, and provides a high-foaming agent based on an amino acid surfactant. The high-foaming agent based on the amino acid surfactant comprises the following components in percentage by mass: 10-35% of alkyl glycoside sulfosuccinate, 10-25% of the amino acid surfactant and the balance of water. According to the high-foaming agent disclosed by the invention, the alkyl glycoside sulfosuccinate salt and the amino acid surfactant are compounded, so that the high-foaming agent is high in biocompatibility, easy to degrade, skin-friendly, non-irritating, relatively high in foaming power and foam stability, low in viscosity of a system after being diluted, capable of being compounded with various substances and widely applied to products such as foam type detergents, facial cleansers and shower gel; the foaming performance of the traditional amino acid surfactant is improved, and meanwhile, the hard water resistance of the amino acid surfactant is improved; compared with a traditional amino acid surfactant, the alkyl glycoside sulfosuccinate salt is lower in cost, and the use cost of the amino acid surfactant formula is reduced.

The invention belongs to the field of hydraulic transmission materials, and provides a preparation method of biodegradable water-ethylene glycol flame-retardant hydraulic fluid. According to the invention, a core-shell micelle structure with a volume median particle size of 80 to 200 nanometers is constructed by adopting a collaborative design of an A1 succinate micelle intermediate and a B1 fatty acid alcohol amine salt anti-wear and anti-rust agent; the performance combination that the kinematic viscosity at 40 DEG C is 36-60 square millimeters per second, the viscosity index is larger than or equal to 140, and the pH value is 8.0-9.5 is achieved, the contradiction between low-temperature fluidity and high viscosity index, between nano-micelle stability and high-pressure abrasion resistance and rust resistance, and between long-term chemical stability and high biodegradability of a traditional water-ethylene glycol hydraulic medium is solved, and the water-ethylene glycol hydraulic medium is suitable for large-scale production. The 28-day biodegradation rate is larger than or equal to 60%, and the lubricating oil has the advantages of being flame-retardant, environmentally friendly and excellent in anti-wear and anti-rust performance, is suitable for a hydraulic system with the rated pressure ranging from 5 MPa to 35 MPa, and has the wide application value.

This invention relates to the field of galvanized steel wire technology, and proposes a high-strength galvanized steel wire and its preparation method. The preparation method of high-strength galvanized steel wire includes the following steps: activating the steel wire, then subjecting it to fluxing to obtain a pretreated steel wire; hot-dip galvanizing the pretreated steel wire, followed by passivation, to obtain high-strength galvanized steel wire; during fluxing, the flux consists of the following components by mass percentage: 20%~25% zinc chloride, 16%~20% ammonium chloride, 1.0%~2.0% additives, 1%~2% nickel chloride, 1%~2% lanthanum nitrate, 0.2%~0.5% ammonium bifluoride, with the balance being water; the additives are palmitamide propyl betaine and disodium lauryl sulfosuccinate. Through the above technical solution, the problem of insufficient wear resistance of galvanized steel wire in related technologies is solved.

Systems and methods for providing alternative fuel, in particular hydrogen photocatalytically generated by a system comprising photoactive nanoparticles and a nitrogenase cofactor are provided. In one aspect, the system includes a water soluble cadmium selenide nanoparticle (CdSe) surface capped with mercaptosuccinate (CdSe-MSA) and a NafY.FeMo-co complex comprising a NafY protein and an iron-molybdenum cofactor (FeMo-co), wherein the CdSe-MSA and NafY·FeMo-co complex are present in about 1:2 to 1:10 molar ratio.

An adhesive composition is described herein. More particularly, an adhesive composition with a hydrophilic adhesive, a hydrophobic adhesive, at least one surfactant, and at least one plasticizer. Specifically, the adhesive is a blend of a continuous phase hydrophilic adhesive, a dispersed phase hydrophobic adhesive, at least one surfactant, at least one plasticizer selected from the group consisting of fatty alcohol ethoxylates, tristyrylphenol ethoxylates, alkyl ether sulfates, sulfosuccinate esters, polysorbates, glycerides and combinations thereof and wherein a weight ratio of the hydrophilic adhesive to the plasticizer is between about 1:4 and about 4:1.

There is provided a composite having a higher dissolution of a drug, the composite including at least a solid dispersion containing the drug and a carrier other than polyvinylpyrrolidone as well as HPMCAS outside the solid dispersion. More specifically, there is provided a composite including at least a solid dispersion containing at least a drug and a carrier selected from the group consisting of a vinylpyrrolidone-vinyl acetate copolymer, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate and first hydroxypropyl methyl cellulose acetate succinate; and second hydroxypropyl methyl cellulose acetate succinate outside the solid dispersion.

This invention provides a continuous method for preparing vitamin E succinate polyethylene glycol ester (TPGS). It uses a strongly acidic cation exchange resin (such as the Amberlyst series) or a perfluorosulfonic acid resin (such as the Nafion series) as a heterogeneous catalyst, which is packed in a fixed bed to catalyze the esterification reaction between vitamin E succinate and polyethylene glycol. This method achieves precise proportioning of reactants, instantaneous mixing, isothermal reaction, and online dehydration, reducing the reaction time from several hours required by existing batch methods to tens of minutes. It allows for long-term stable use, requires no complex post-processing, and produces products with high yield, good purity, and light color. The preparation method of this invention solves the problems of difficult catalyst recovery, excessive waste, low efficiency, and unstable product quality in existing methods, making it particularly suitable for large-scale, continuous, and green production of TPGS.

The application discloses a kit for predicting prognosis of breast cancer targeted therapy and adverse reactions of diarrhea, and the kit is used for evaluating the curative effect of pyrotinib on HER2 positive breast cancer and the risk of diarrhea by detecting the expression levels of IL-6, HER2, EGFR, JAK2, Src and STAT3; the kit comprises specific antibodies, antibody conjugates and immunohistochemical detection reagents, wherein the antibody conjugate comprises carboxyl functionalized magnetic beads, and is obtained by modification through hexadiene succinic acid, (E)-5-methylhex-3-ene acid and other reagents; qualitative and quantitative analysis of the markers in tumor tissues is carried out by using an immunohistochemical technology, the kit provides a reliable tool for individualized prognosis evaluation and monitoring of adverse reactions of diarrhea in breast cancer targeted therapy, and is helpful for formulating precise treatment plans in the clinic and improving the treatment benefits of patients.

Provided is a method for producing hydroxypropyl methylcellulose acetate succinate by which particle density increment is suppressed and dissolution time is shortened. The method for producing hydroxypropyl methylcellulose acetate succinate essentially includes a liquid removal step, a first drying step, and a second drying step, wherein the first drying step involves drying of hydroxypropyl methylcellulose acetate succinate using a fluid-bed dryer until it reaches a water content of 30% by mass while maintaining the product temperature at 28° C. or lower.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

An agrochemical concentrate comprises lecithin and at least one agrochemical active. The agrochemical concentrate may also comprise a dispersant selected from sucrose ester, alkylpolyglucoside, alkylnaphthalene sulphonates, phosphate ester, sorbitol ester, polyglycerol ester, alkyl sulphates, sodium lauryl sulphate, alkylglucamides, and dialkyl sulphosuccinates. An aqueous formulation comprises a dilution of the agrochemical concentrate in an electrolyte. A pre-blend comprises lecithin and a dispersant. A method of preparing the agrochemical concentrate and a method for treating vegetation are also disclosed.

The invention relates to the technical field of medicines, and provides a semeglutide coated tablet and a preparation method thereof. The chip-coated sheet comprises a chip core layer and a shell layer, the tablet core layer comprises a first absorption enhancer; the shell layer comprises a second absorption enhancer; the first absorption enhancer and the second absorption enhancer are selected from the group consisting of sodium 8-(2-hydroxybenzamido) caprylate, Tween 80, lauryl sodium sulfate, sodium caprate, polyglycerol-3 diisostearate, oleic acid, lauric acid, sodium deoxycholate, sodium cholate, polyoxyethylene (35) castor oil, PEG-vitamin E succinate, PEG-vitamin D3 succinate and pluronic. The invention relates to a preservative which is prepared from the following raw materials: polyethylene glycol, a methoxy polyethylene glycol-polycaprolactone copolymer, sucrose fatty acid ester, 15-hydroxystearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The coated tablet provided by the invention adopts a double-layer structure consisting of the tablet core layer and the shell layer, so that the bioavailability of the preparation can be remarkably improved, the oral dosage can be hopefully and greatly reduced, and the medication cost is reduced.

The invention relates to the technical field of bioenergy active hydrogel, in particular to silk fibroin hydrogel with bioenergy activity and a preparation method of the silk fibroin hydrogel. The preparation method comprises the following steps: carrying out esterification reaction on a silk fibroin solution containing hydroxyl and phenolic hydroxyl and succinic anhydride to obtain succinic acid esterified silk fibroin; carrying out dissolution promoting treatment on the succinic acid esterified silk fibroin to obtain gel precursor liquid; a hydrogen peroxide solution of horse radish peroxidase and the gel precursor fluid are subjected to a cross-linking reaction, and the silk fibroin hydrogel containing succinic acid esterified silk fibroin is obtained. According to the preparation method, firstly, a silk fibroin solution and succinic anhydride are subjected to an esterification reaction, then horse radish peroxidase and a hydrogen peroxide solution are subjected to a cross-linking reaction, a stable hydrogel structure is formed, and the gel can improve the energy metabolism level of intervertebral disc cells.

The invention relates to the technical field of bauxite flotation desiliconization, and particularly discloses a desiliconization agent for bauxite beneficiation and a preparation method of the desiliconization agent. The desiliconizing agent is prepared by taking a modified carboxylic acid copolymer as a main collecting agent and matching with sulfonated succinate, sodium lignin sulfonate, a function regulator, a cationic additive and a pH regulator. According to the agent, selective collection of silicon minerals is enhanced through multi-component cooperation, the desilicication rate exceeds 90%, the aluminum recovery rate exceeds 85%, the dosage is only 320-350 g / t, and the agent is suitable for various bauxite types, easy and convenient to prepare and easy to industrialize.

A catalyst component for olefin polymerization, a preparation method therefor and a use thereof are provided. The catalyst component contains elemental magnesium, elemental titanium and an internal electron donor. The internal electron donor has a phosphate ester, and an α-cyanosuccinate and / or a substituted α-cyanosuccinate. A molar ratio of the phosphate ester to the elemental magnesium is 0.0002-0.002:1. When the catalyst is used for olefin polymerization, especially for propylene polymerization, the obtained polymer has the characteristics of a high Z+1 average molecular weight and a good balance of rigidity and toughness.

The invention discloses an antibacterial and anti-inflammatory regenerative pith capping material and a preparation method thereof, CTAB is used as a template, TEOS, TEP and Ca (NO3) 2 are prepared into a solution according to a ratio of 4: 1: 1, mixing, aging, freeze drying and calcination at 650 DEG C are carried out, (3-triethoxysilylpropyl) succinate is used for treatment at 40-70 DEG C to realize surface carboxyl containing, or APTES / MPTMS is used for introducing-NH2 or-SH functional groups, curcumin with a concentration of 1-5 mg / mL is dissolved in absolute ethyl alcohol, and the antibacterial and anti-inflammatory regenerative pith capping material is obtained. The preparation method comprises the following steps: mixing the curcumin with MBG according to a ratio of 30: 1 at 40-60 DEG C, oscillating for 2-8 hours, centrifuging at 10000-14000 rpm, and freeze-drying to obtain Cur-MBG, the obtained material is in a monodisperse sphere shape, ordered and uniform mesopores, and realizes a curcumin loading rate of about 21-25%.

Provided are compositions suitable for skin care. Certain compositions comprise a. one or more a C20-24 fatty alcohols; b. one or more anionic surfactants; c. one or more thickening polysaccharides comprising succinoglycan; d. one or more emollients comprising at least one natural butter having a natural butter which is solid at 20°C and has a melting point below 50°C; and e. about 50 to about 95 wt.% of water by weight of the total composition, wherein the composition is in the form of an emulsion.

The invention belongs to the technical field of preparation of drug carriers, and particularly provides a nano-micelle for embedding curcumin as well as a preparation method and application of the nano-micelle. The preparation method of the nano-micelle for embedding curcumin comprises the following steps: dissolving shellac, PGPR, beta-sitosterol succinate and curcumin in liquid coconut oil, and adding ethanol to form an organic phase; and after mixing with a xanthan gum aqueous solution, carrying out pre-emulsification, fine emulsification, gradient cooling and cold storage curing to obtain the nano-micelle. The encapsulation efficiency of the nano-micelle is greater than or equal to 93%, the drug loading capacity reaches 1.58%-4.15%, and the nano-micelle has efficient pH response targeting property; wherein the beta-sitosterol succinate enhances the drug-loading core density, the shellac constructs a gastric juice barrier, and the PGPR maintains the micelle dispersibility, so that the oral bioavailability of the curcumin can be improved by 46-55 times compared with that of free curcumin, and the curcumin is suitable for efficient delivery of food functional components or drugs.

The invention provides a preparation method of an adhesive for an excrement storage bag capable of being smeared, and belongs to the field of preparation of adhesives for excrement storage bags. The method comprises the following steps: dissolving a mixture A in anhydrous dichloromethane, carrying out a stirring reaction under the protection of inert gas, and sequentially carrying out hydrochloric acid washing, saturated saline solution washing, rotary evaporation concentration and diethyl ether precipitation to obtain two-arm polyethylene glycol allyl succinate; wherein the mixture A is prepared from the following components in parts by weight: 20 to 40 parts of two-arm type polyethylene glycol, 1 to 2 parts of allyl succinic anhydride and 1 to 2 parts of dimethylaminopyridine. The prepared adhesive can be smeared on the surface of any uneven skin around the stoma, and the adhesive can generate viscosity through ultraviolet irradiation, so that an excrement storage bag is tightly adhered to the skin, excrement leakage is prevented, and tissues around the stoma are protected. And the adhesive can be easily eluted by using medical alcohol, so that the excrement storage bag is convenient to replace. The used materials are simple and easy to obtain, the operation is simple, the price is low, and good news is brought to vast stoma patients.