147 results about "Succinates" patented technology

The invention relates to a crystal type mild cleansing cream and a preparation method thereof, and belongs to the technical field of cosmetics. The crystalline mild cleansing cream is prepared from the following components: glycerol, a mixed amino acid surfactant, lauryl hydroxyl sulfobetaine, disodium lauryl sulfosuccinate, a chelating agent, citric acid, a preservative, a skin conditioning component and water, wherein the mixed amino acid surfactant is formed by mixing solid potassium cocoyl glycinate, solid sodium cocoyl glycinate and a sodium cocoyl glycinate aqueous solution; the cleansing cream comprises the following components in percentage by mass: 25%-35% of glycerol, 18%-25% of active ingredients of the mixed amino acid surfactant, 3%-4.5% of lauryl hydroxyl sulfobetaine and 1%-3% of disodium lauryl sulfosuccinate. According to the crystal type mild cleansing cream, no extra thickening agent component is used, the cream body which is good in texture and stable is obtained only through synergistic thickening of the three amino acid surfactants, irritation is small, sensitive skin friendliness is achieved, the preparation technology is simple, and cost is low.

The invention belongs to the technical field of stem cell biological preparations, and particularly relates to an anti-aging compound preparation based on stem cells and application of the anti-aging compound preparation in delaying skin aging. The composition is composed of an inner water phase, a middle oil phase and an outer water phase, wherein the inner water phase is prepared from the following components: stem cell exosomes, hyaluronic acid, nicotinamide ribose, trehalose, mannitol, glycine and a citric acid buffer solution; the medium oil phase is prepared from the following components: medium chain triglyceride, shea butter, vitamin E succinate, PEG (Polyethylene Glycol) modified ceramide NP and cholesterol succinic acid monoester; the external water phase is prepared from the following components: polydatin, cellulose nanocrystals and an emulsifying agent. On the basis of a W / O / W emulsion system, a multi-layer anti-aging mechanism is constructed by utilizing a three-dimensional delivery framework of an inner water phase, an oil phase and an outer water phase and space-time synergy of active ingredients, the exosome permeation efficiency is improved through microneedle introduction, and the anti-oxidation and barrier repair effects are achieved by using multiple ingredients.

The invention provides an additive composition for promoting itraconazole absorption, and the additive composition is prepared from the following components in parts by mass: 20 to 40 parts of modified hydroxypropyl methylcellulose acetic acid succinate, 10 to 25 parts of copovidone, 5 to 15 parts of N-capryloyl sodium salicylate, 2 to 8 parts of nano silicon dioxide and 3 to 10 parts of polyoxyethylene-polyoxypropylene segmented copolymer. According to the additive composition disclosed by the invention, the problems of dissolution rate, bioavailability and stability of the itraconazole oral preparation are comprehensively solved through polymer modification, compounding synergy and parameter optimization, and the process cost is remarkably lower than that of the prior art.

The present invention relates to a dispersant for graphite and graphene and its application. The composition is a synergistic combination of alkyl sulfosuccinate and polyalkylene glycol. Appropriate adding amount thereof can quickly and easily disperse graphite and graphene in the medium, improve its dispersion uniformity and stability, delay its sedimentation, and inhibit its re-accumulation. Furthermore, the present invention can apply graphite and graphene to other media besides non-water-based or organic solvents. The composition of the present invention does not contain flammable volatile chemicals, any fluorine-, silicon- or phosphorus-based compounds, or any aromatic substances. The present invention can not only reduce environmental pollution but also improve the operational safety of relevant personnel.

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid dispersion-based sustained-release drug composite carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out synergistic spray drying on double polymers (hydroxypropyl methylcellulose acetate succinate and polyvinylpyrrolidone-vinyl acetate copolymer) to form a solid dispersion; compounding with mesoporous silica and calcium silicate for localization, and spraying ethanol to activate pores; calcium stearate and magnesium stearate are sequentially added for lubrication; prefabricating a sustained-release skeleton master batch; and finally, mixing, rolling and forming. According to the method, through hierarchical structural design, the drug stability, the powder fluidity and the release controllability are remarkably improved, the method is suitable for industrial production of the dihydroergoline mesylate sustained release preparation, and a release curve is smooth and reliable.

The present invention provides a method for cleaning an object surface, the method having enzyme activity even if using high concentrations of surfactants and an enzyme together, and exhibiting excellent cleaning performance for solid fat-containing contamination adhering to the object surface of tableware or the like without being affected by the hardness of water used for cleaning (for example, 0 to 20° dH (by German hardness)).A method for cleaning an object surface including, bringing a cleaning liquid obtained by diluting a liquid cleaning agent composition with water into contact with the object surface, the liquid cleaning agent composition containing the following component (a), component (b) and component (e) and water,component (a): an alkyl sulfosuccinic acid ester having an alkyl group with 5 or more and 18 or less carbons or a salt thereof,component (b): one or more surfactants selected from semipolar surfactants and amphoteric surfactants (excluding sulfobetaines), andcomponent (e): an enzyme.

The invention provides a recombinant lipase mutant and application thereof in preparation of vitamin E succinate. The recombinant lipase mutant is obtained by performing single mutation on the 104th site, the 106th site, the 154th site, the 190th site, the 278th site, the 281th site or the 282th site of an amino acid sequence as shown in SEQ ID NO.1. The invention further provides a preparation method of the recombinant lipase mutant. The method has the beneficial effects that the recombinant lipase mutant for efficiently expressing the lipase CALB is used as a catalyst, so that the vitamin E succinate can be synthesized in an organic reaction system, the conversion rate of the vitamin E succinate can reach 90% or above, the relative enzyme activity of the recombinant lipase mutant is improved by 15% compared with that of a wild type, and the yield of the recombinant lipase mutant is improved. And the vitamin E succinate is synthesized by using the recombinant lipase mutant, so that the reaction condition is mild, the process operation is simple, the method is environment-friendly, the requirement on equipment is reduced, the production cost is greatly reduced, and the method has a wide application prospect in industrial application.

The invention relates to the technical field of surfactants, and particularly discloses a preparation method and application of a sulfosuccinate type surfactant, and the preparation method specifically comprises the following steps: (1) esterification reaction: under the protection of inert gas, adding fatty alcohol and carboxylic acid anhydride, introducing gas for 10-20 minutes, adding a difunctional acidic site catalyst, heating to 95-105 DEG C, and reacting for 2-3 hours to obtain an esterification product; and (2) sulfonation reaction: cooling the esterification product to 70-80 DEG C, dropwise adding 20-40wt% of sulfonating agent aqueous solution, preserving heat for 1-2 hours after dropwise adding, and then performing post-treatment to obtain the sulfosuccinate type surfactant. In the preparation process, one-pot preparation is realized by regulating and controlling process conditions and developing a catalyst to efficiently catalyze esterification and sulfonation, intermediate products do not need to be separated between esterification and sulfonation, material loss caused by transfer and separation is avoided, the adopted catalyst can be used for inhibiting premature oxidation of a sulfur source in the sulfonation process, and the sulfonation efficiency is improved. The generation of byproducts is reduced, and the yield is improved.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

The invention relates to the technical field of grease, in particular to photo-thermal oxidation resistant diglyceride oil as well as a preparation method and application thereof. The photo-thermal oxidation resistant diglyceride oil is prepared from 80 to 120 parts of vegetable oil, 15 to 25 parts of glycerol, 5 to 8 parts of compound lipase and 0.5 to 2 parts of nano antioxidant compound, the nano antioxidant compound is prepared from rosmarinic acid / lecithin nano liposome, a tea polyphenol-zinc compound and a vitamin E succinate compound. According to the photo-thermal oxidation resistant diglyceride oil disclosed by the invention, a synergistic effect is formed through the nano anti-oxidation system and the compound lipase, so that the oxidation stability of the oil under light and heat conditions is remarkably improved. According to the preparation method disclosed by the invention, through segmented temperature control reaction and segmented addition of the antioxidant, maximization of enzyme activity at high temperature is ensured, thermal decomposition of antioxidant components at the initial stage of the high temperature is reduced, and finally, accurate control of the acid value amplification and the peroxide value amplification in application of the frying oil is realized.

The present invention discloses a method for improving the liposome encapsulation efficiency by modifying a cholesterol composite prodrug. Specifically, the drug curcumin and vitamin E succinate are first reacted with cholesterol to obtain a cholesterol-curcumin complex and a cholesterol-vitamin E succinate complex. The two obtained complexes are then uniformly mixed with a lipid and then prepared by thin film hydration to obtain drug-loaded liposomes. The present invention utilizes the cholesterol composite prodrug method to improve the low solubility of curcumin and vitamin E succinate in liposomes, improve the encapsulation efficiency of the two drugs in liposomes, and provide a new approach for the preparation of liposomes containing poorly soluble compounds.

The invention discloses a preparation method of walnut protein isolate, and the walnut protein isolate prepared by the method has the efficacy of improving dysmnesia of old people and can be used for preparing acidic food, emulsified food and foam food. According to the method disclosed by the invention, the high-quality walnut protein isolate is prepared by taking degreased walnut powder as a raw material and utilizing the principles of reverse micelle dissolution, isoelectric precipitation and high solubility of bis (2-ethylhexyl) sodium sulfosuccinate in ethanol. The walnut protein isolate prepared by the invention has the advantages of high apparent property, high protein content, strong solubility, strong emulsifying ability, strong foaming ability, high in-vitro old-age model digestibility and AChE inhibition ability and antioxidant ability of strong digestion products.

The invention belongs to the technical field of lubricating oil, and particularly relates to an internal combustion engine oil composite additive and a preparation method and application thereof. The internal combustion engine oil composite additive is prepared from the following raw materials in percentage by mass: 5 to 25 percent of sulfonate, 5 to 12.5 percent of an oxidation and corrosion inhibitor, 5 to 12.5 percent of an anti-wear agent, 5 to 10 percent of an antioxidant, 1 to 2.5 percent of heptadecenyl imidazoline succinate, 0.5 to 1 percent of a nano compound and the balance of a dispersing agent, the nano compound is a compound of nano molybdenum carbide and nano aluminum oxide. Lubricating oil adopting the internal combustion engine oil composite additive has good wear resistance, water resistance and corrosion resistance, meanwhile, good low-temperature fluidity and low loss, oxidative deterioration of engine oil and generation of sediments can be effectively inhibited, the low-speed preignition frequency of an engine can be reduced, and the service life of the engine oil is prolonged. Timing chain abrasion protection and valve system abrasion protection are provided for an engine.

This disclosure provides formulations and processes that reduce the injection molding cycle times for poly(hydroxyalkanoate) blends which may contain a succinate polymer such as poly(butylene succinate), a filler such as lignocellulosic biomass and other additives. Blending of PHA with the second polymer may increase biodegradability and compostability.

The present invention provides a method for cleaning an object surface, the method having enzyme activity even if using high concentrations of surfactants and an enzyme together, and exhibiting excellent cleaning performance for solid fat-containing contamination adhering to the object surface of tableware or the like without being affected by the hardness of water used for cleaning (for example, 0 to 20° dH (by German hardness)).A method for cleaning an object surface including, bringing a cleaning liquid obtained by diluting a liquid cleaning agent composition with water into contact with the object surface, the liquid cleaning agent composition containing the following component (a), component (b); component (c) and component (e) and water,component (a): an alkyl sulfosuccinic acid ester or a salt thereof,component (b): one or more surfactants selected from a semipolar surfactant and an amphoteric surfactant,component (c): a nonionic surfactant, andcomponent (e): an enzyme.

The invention belongs to the technical field of high-foaming agents, and provides a high-foaming agent based on an amino acid surfactant. The high-foaming agent based on the amino acid surfactant comprises the following components in percentage by mass: 10-35% of alkyl glycoside sulfosuccinate, 10-25% of the amino acid surfactant and the balance of water. According to the high-foaming agent disclosed by the invention, the alkyl glycoside sulfosuccinate salt and the amino acid surfactant are compounded, so that the high-foaming agent is high in biocompatibility, easy to degrade, skin-friendly, non-irritating, relatively high in foaming power and foam stability, low in viscosity of a system after being diluted, capable of being compounded with various substances and widely applied to products such as foam type detergents, facial cleansers and shower gel; the foaming performance of the traditional amino acid surfactant is improved, and meanwhile, the hard water resistance of the amino acid surfactant is improved; compared with a traditional amino acid surfactant, the alkyl glycoside sulfosuccinate salt is lower in cost, and the use cost of the amino acid surfactant formula is reduced.

The present invention discloses a nanoparticle for dual-targeted treatment of breast cancer, and its preparation method and application. The nanoparticle for dual-targeted treatment of breast cancer uses polysaccharide-cholesterol hemisuccinate amphiphilic conjugate of Dendrobium officinale as a drug carrier to encapsulate anti-breast cancer chemotherapeutic drugs, and the surface of the drug carrier is modified with folic acid ligands. By using polysaccharide of Dendrobium officinale with immunomodulatory activity as a carrier and combining with folic acid ligands with active targeting function, the present invention realizes dual-targeting of breast cancer and exerts the effect of chemoimmunotherapy. After the prepared nanoparticles are delivered to solid tumors through passive and active targeting, the tumor cells are killed by the released chemotherapeutic drug (doxorubicin), and the immunogenic cell death (ICD) is enhanced by polysaccharide of Dendrobium officinale, promoting the proliferation of natural killer cells (NK cells), stimulating the maturation of dendritic cells, and coordinately regulating various immune cells, while preventing breast cancer lung metastasis.

The invention belongs to the field of hydraulic transmission materials, and provides a preparation method of biodegradable water-ethylene glycol flame-retardant hydraulic fluid. According to the invention, a core-shell micelle structure with a volume median particle size of 80 to 200 nanometers is constructed by adopting a collaborative design of an A1 succinate micelle intermediate and a B1 fatty acid alcohol amine salt anti-wear and anti-rust agent; the performance combination that the kinematic viscosity at 40 DEG C is 36-60 square millimeters per second, the viscosity index is larger than or equal to 140, and the pH value is 8.0-9.5 is achieved, the contradiction between low-temperature fluidity and high viscosity index, between nano-micelle stability and high-pressure abrasion resistance and rust resistance, and between long-term chemical stability and high biodegradability of a traditional water-ethylene glycol hydraulic medium is solved, and the water-ethylene glycol hydraulic medium is suitable for large-scale production. The 28-day biodegradation rate is larger than or equal to 60%, and the lubricating oil has the advantages of being flame-retardant, environmentally friendly and excellent in anti-wear and anti-rust performance, is suitable for a hydraulic system with the rated pressure ranging from 5 MPa to 35 MPa, and has the wide application value.

This invention relates to the field of galvanized steel wire technology, and proposes a high-strength galvanized steel wire and its preparation method. The preparation method of high-strength galvanized steel wire includes the following steps: activating the steel wire, then subjecting it to fluxing to obtain a pretreated steel wire; hot-dip galvanizing the pretreated steel wire, followed by passivation, to obtain high-strength galvanized steel wire; during fluxing, the flux consists of the following components by mass percentage: 20%~25% zinc chloride, 16%~20% ammonium chloride, 1.0%~2.0% additives, 1%~2% nickel chloride, 1%~2% lanthanum nitrate, 0.2%~0.5% ammonium bifluoride, with the balance being water; the additives are palmitamide propyl betaine and disodium lauryl sulfosuccinate. Through the above technical solution, the problem of insufficient wear resistance of galvanized steel wire in related technologies is solved.

Systems and methods for providing alternative fuel, in particular hydrogen photocatalytically generated by a system comprising photoactive nanoparticles and a nitrogenase cofactor are provided. In one aspect, the system includes a water soluble cadmium selenide nanoparticle (CdSe) surface capped with mercaptosuccinate (CdSe-MSA) and a NafY.FeMo-co complex comprising a NafY protein and an iron-molybdenum cofactor (FeMo-co), wherein the CdSe-MSA and NafY·FeMo-co complex are present in about 1:2 to 1:10 molar ratio.

An adhesive composition is described herein. More particularly, an adhesive composition with a hydrophilic adhesive, a hydrophobic adhesive, at least one surfactant, and at least one plasticizer. Specifically, the adhesive is a blend of a continuous phase hydrophilic adhesive, a dispersed phase hydrophobic adhesive, at least one surfactant, at least one plasticizer selected from the group consisting of fatty alcohol ethoxylates, tristyrylphenol ethoxylates, alkyl ether sulfates, sulfosuccinate esters, polysorbates, glycerides and combinations thereof and wherein a weight ratio of the hydrophilic adhesive to the plasticizer is between about 1:4 and about 4:1.

There is provided a composite having a higher dissolution of a drug, the composite including at least a solid dispersion containing the drug and a carrier other than polyvinylpyrrolidone as well as HPMCAS outside the solid dispersion. More specifically, there is provided a composite including at least a solid dispersion containing at least a drug and a carrier selected from the group consisting of a vinylpyrrolidone-vinyl acetate copolymer, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate and first hydroxypropyl methyl cellulose acetate succinate; and second hydroxypropyl methyl cellulose acetate succinate outside the solid dispersion.

This invention provides a continuous method for preparing vitamin E succinate polyethylene glycol ester (TPGS). It uses a strongly acidic cation exchange resin (such as the Amberlyst series) or a perfluorosulfonic acid resin (such as the Nafion series) as a heterogeneous catalyst, which is packed in a fixed bed to catalyze the esterification reaction between vitamin E succinate and polyethylene glycol. This method achieves precise proportioning of reactants, instantaneous mixing, isothermal reaction, and online dehydration, reducing the reaction time from several hours required by existing batch methods to tens of minutes. It allows for long-term stable use, requires no complex post-processing, and produces products with high yield, good purity, and light color. The preparation method of this invention solves the problems of difficult catalyst recovery, excessive waste, low efficiency, and unstable product quality in existing methods, making it particularly suitable for large-scale, continuous, and green production of TPGS.

Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG). Methods of restoring tricarboxylic acid (TCA) cycle function in a cell deficient for propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT) by contacting the cell with a succinate derivative or pro-drug, such as TSG, are also described.

The application discloses a kit for predicting prognosis of breast cancer targeted therapy and adverse reactions of diarrhea, and the kit is used for evaluating the curative effect of pyrotinib on HER2 positive breast cancer and the risk of diarrhea by detecting the expression levels of IL-6, HER2, EGFR, JAK2, Src and STAT3; the kit comprises specific antibodies, antibody conjugates and immunohistochemical detection reagents, wherein the antibody conjugate comprises carboxyl functionalized magnetic beads, and is obtained by modification through hexadiene succinic acid, (E)-5-methylhex-3-ene acid and other reagents; qualitative and quantitative analysis of the markers in tumor tissues is carried out by using an immunohistochemical technology, the kit provides a reliable tool for individualized prognosis evaluation and monitoring of adverse reactions of diarrhea in breast cancer targeted therapy, and is helpful for formulating precise treatment plans in the clinic and improving the treatment benefits of patients.

Provided is a method for producing hydroxypropyl methylcellulose acetate succinate by which particle density increment is suppressed and dissolution time is shortened. The method for producing hydroxypropyl methylcellulose acetate succinate essentially includes a liquid removal step, a first drying step, and a second drying step, wherein the first drying step involves drying of hydroxypropyl methylcellulose acetate succinate using a fluid-bed dryer until it reaches a water content of 30% by mass while maintaining the product temperature at 28° C. or lower.

The dispersion of amorphous uridine triacetate in hypromellose acetate succinate-MG and optionally in copovidone is disclosed. The amorphous dispersion composition enables a high loading of uridine. The amorphous dispersion composition also has good stability and oral bioavailability. The amorphous dispersion composition can be used to deliver exogenous uridine to mammalian subjects in need of exogenous uridine, such as subjects having an energy deficiency disorder or certain other conditions.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.