Super-molecular hydrogel double-medicament carrier and preparation method as well as application thereof

A supramolecular hydrogel and hydrophobic drug technology, applied in the field of biomedical engineering materials, to achieve good shear thinning, lower concentration and temperature requirements, and improve bioavailability
CN102247602AInactive Publication Date: 2011-11-23SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2011-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a super-molecular hydrogel double-medicament carrier for simultaneously loading hydrophilic and hydrophobic medicaments and a preparation method as well as application thereof. The method comprises the following operating steps of: performing chemical modification on the hydrophobic medicament by using methoxypolyethylene glycol to synthesize a water-soluble macromolecularprodrug; physically mixing prodrug molecules with the hydrophilic medicament; further mixing the mixed solution with an alpha-cyclodextrin solution and stirring; and standing at room temperature to obtain the super-molecular hydrogel double-medicament carrier for simultaneously loading the hydrophilic and the hydrophobic medicaments. The carrier has the advantages of easiness in operation, adjustable gel strength and gelation time, forming at room temperature, no chemical crosslinking reaction or organic solvent, high bioavailability, sustainable and controllable release of the medicament andthe like, and is expected to be widely applied to the field of biomedical engineering materials.
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Description

technical field

[0001] The invention belongs to the field of biomedical engineering materials, in particular to a supramolecular hydrogel dual drug carrier capable of simultaneously loading hydrophilic and hydrophobic drugs, and a preparation method and application thereof. Background technique

[0002] Combination therapy of two or more drugs is currently an effective method for clinically treating diseases and tissue defects. The key to the implementation of this technology is to control the dosage and cycle of each drug. As a commonly used class of drug carriers, hydrogels have the advantages of high loading capacity, protection of drugs from biodegradation and clearance, and sustainable release of drugs, and have been studied as dual drug carriers in recent years. For example, Konishi et al. loaded cisplatin and doxorubicin in glutaraldehyde-crosslinked gelatin matrix at the same time, and achieved the purpose of efficiently inhibiting tumor cells through the synergisti...

Claims

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