31results about How to "Shorten the gelation time" patented technology

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

The present invention provides a method for the real-time continuous monitoring of a change or density and/or viscosity within a test sample. Such methods can be used to determine the occurrence of a chemical reaction within a test sample where the same causes and increase or decrease in the density and/or viscosity of the sample due to, for example, a gelation, precipitation or coagulation occurring within the test sample. There is further provided a multi-resonator apparatus for use in measuring the density and/or viscosity of a test sample in which the multi-beam resonator is immersed.

This invention provides a preparation, composition, product, and application of a photo-coupled synergistically crosslinked hydrogel material. The preparation includes dissolving Component A including a photosensitive polymer derivative having o-nitrobenzyl phototriggers and Component B including a polymer derivative having amine or alkene (double group) or sulfhydryl group in a biocompatible medium to obtain solution A and solution B, respectively; mixing the solution A and solution B homogeneously to obtain a hydrogel precursor solution; initiating photo-coupled synergistic crosslinking under an irradiation of a UV light to form the hydrogel. The irradiation causes the o-nitrobenzyl phototriggers to generate an aldehyde group/keto group or a nitroso group to initiate photo-coupled synergetic crosslinking. The photo-coupled synergistically crosslinked hydrogel has applications in tissue engineering, regenerative medicine, 3D printing and as a carrier of cell, protein or drug.

The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying polymer, and gelation agent into a hydrocarbon reservoir. Delays of weeks are observed.

The invention discloses a method for producing an alumina silica gel anchoring agent for corundum mullite composite ceramic, which comprises: using silicasol and alumina colloid as raw materials, controlling PH of the alumina colloid, using sol-gel processing to produce the alumina silica gel, controlling the content of alumina silica by dewatering in the alumina silica gel producing process, and controlling the gelling time by adding ammonial solution or acetylacetone, controlling the crystal system of mullite phase produced from burning process of the alumina silica gel by adding the aluminun trifluoride mineralization agent. The alumina silica gel can be used in the ceramic and fire resistive materials producing process as the anchoring agent, also can be used in production of mullite super fine. The crystal form can be controlled by adding the mineralization agent to improve the capacity of the ceramic and fire resistive materials.

The method for preparing electrochemical biological transducer with TiO2 gel film includes the following steps: a) preparing TiO2 film, soaking ITO electrode in 2-8 mol/L of sodium hydroxide solution for 5-12 hour, immersing the electrode in 50-300 mM butyl exter titanate for 2-5 minute, immersing the electrode in anhydrous alcohol for 1-3 minute and then in secondary water for 1-3 minute; b) immersing electrode obtained from step a) in aqueous solution of zyme (concentration of 2-4 mg/L) for 30-120 minute. The prepared transducer can hold its activity for 14 days and it can be reused.

The invention discloses a totarol antibacterial nano hydrogel with a whey protein as a matrix and a preparation method thereof, and belongs to the bacteriostatic gel biological technical field. Preparation raw materials comprise a whey protein gel, totarol and absolute ethyl alcohol. The preparation method adopts a sol-gel technique and comprises the steps of whey protein gel preparation, totarol embedding, ultrasonic treatment and standing and sterilization. According to the antibacterial nano hydrogel formula, a novel food-borne bacteriostatic agent is achieved. At the same time, the antibacterial nano hydrogel has the characteristics and advantages of the whey protein and the totarol. A whey protein polymer plays dispersion stabilizer, gel matrix and multiple roles in the antibacterial nano hydrogel system, no any crosslinking agents and initiators are added, toxic effects on a human body cannot be produced, and the use is safer and more effective; the preparation method has the advantages of simple equipment and technological process for producing the antibacterial nano hydrogel, mild conditions, low cost and easy popularization, and is suitable for industrialized production.

The invention provides a nanometer metal oxide and a preparation method thereof, and belongs to the fields of preparation technologies of nanometer inorganic compound photocatalysis materials and dyes. A halide or inorganic salt containing metal ions is selected as a metal ion source, a complexing agent, sucrose, glucose, acrylamide, bisacrylamide, agar, gelatin and carboxymethyl cellulose are selected as gel raw materials, the metal ions are uniformly dispersed, an industrial irradiation device is used to irradiate a raw material solution or emulsion in order to form a gel with a spatial network structure, the nanometer metal oxide is prepared through later grinding and sintering technologies, and the nanometer metal oxide can be used as an excellent photocatalyst or dye. The preparation method has the advantages of simplicity, stable process, strong operability, great reduction of the use amount of the gel raw materials, no need of heating, no need of special treatment of the raw materials, and realization of large batch production by using the industrial irradiation device.

The invention relates to the field of biomedical materials, and discloses a preparation method of an artemisinin liposome-loaded alginate-silk fibroin composite hydrogel. The preparation method comprises the following steps that an artemisinin drug and other lipids are dissolved in ethanol according to a proper proportion by an ethanol injection method, and injecting and evaporating are carried out to prepare an artemisinin drug-loaded liposome; degumming is carried out by using a sodium carbonate solution, silk fibroin is stirred and dissolved by selecting a CaCl2-ethanol-H2O ternary system, and centrifugal dialyzing and freeze-drying are carried out to obtain silk fibroin; and sodium alginate solution is prepared, then a mixture is formed from drug-loaded liposome, silk fibroin and sodium alginate, and centrifugal ultrasonic treatment is carried out to prepare the hydrogel. The artemisinin liposome-loaded alginate-silk fibroin composite hydrogel has excellent drug controlled release ability and extremely high drug bioavailability, the hydrogel prepared by compounding sodium alginate and silk fibroin is further very good in biocompatibility, and the sodium alginate and the silk fibroin form synergistic complementation, so that the mechanical property of the silk fibroin hydrogel is improved.

Disclosed are a biodegradable, biocompatible hydrogel that can be used for sealants of suppressing the leakage of blood or air during surgical operation, tissue adhesives, anti-adhesive agents and drug delivery carriers, and a method for producing the same

The invention provides a cobalt-doped gel and a preparation method thereof. The preparation method is achieved by a sol-gel method combined with a technical route containing an acid catalytic hydrolysis and a base catalytic hydrolysis to prepare a cobalt-doped sol. The method is as below: preparing the raw materials of tetraethoxysilane and tributyl borate under the conditions of 60-70 DEG C, pH value of 3-5, and deionized water in substoichiometry into a silicon-boron sol; meanwhile, preparing a salt solution of alkali metal, aluminum and cobalt; adding the salt solution into the silicon-boron sol by multiple times, and further hydrolyzing the borosilicate sol under basic conditions to obtain a homogeneous cobalt-doped sol; and sealing the cobalt-doped sol and allowing to stand at 80-120 DEG C for gelation, aging and drying. By changing the composition and content of raw materials, the method can obtain the cobalt-doped gel with controllable compressive strength and half-life insurance of the cobalt-doped hollow glass microspheres.

The invention discloses temperature-sensitive hydrogel as well as a preparation method and application thereof, and relates to the field of pharmaceutical preparations. The temperature-sensitive hydrogel is prepared from poloxamer 407, chitosan, silicon modified polyacrylamide, a biological solution and acid. The method has the effect of shortening the gelation time of the poloxamer.

The object of the present invention is a composition in powder form comprising the following polysaccharides alginic acid or sodium alginate,—pectin, chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder. The process for preparing said powder by an atomization process and its use in the treatment of cutaneous wounds and in the sector of food preservation are additional objects of the invention. Moreover, additional objects of the invention are the composition in the form of solution or liquid suspension that represents the starting material to obtain said powder and the process for preparing said liquid composition.

The invention discloses temperature-sensitive calcium phosphate bone cement and a preparation method thereof. The temperature-sensitive calcium phosphate bone cement comprises solid-phase powder and aliquid-phase component. The solid-phase powder is calcium salt. The liquid-phase component is prepared by mixing the following components: a gamma-glycidyl ether oxypropyl trimethoxysilane aqueous solution, a chitosan acetic acid aqueous solution, a sodium glycerophosphate aqueous solution and a bletilla striata polysaccharide aqueous solution. According to the temperature-sensitive calcium phosphate bone cement, a temperature-sensitive bone cement system prepared from chitosan, beta-disodium glycerophosphate and alpha-tricalcium phosphate is adopted and sol-gel conversion temperature sensitization is realized by regulating and controlling the interaction between the temperature-sensitive calcium phosphate bone cement and water molecules. After component optimization, the beta-sodium glycerophosphate is reduced, the toxicity is reduced, the gelation time of the hydrogel is shortened, the mechanical property of the bone cement is enhanced, the collapse resistance is improved, and the defect of poor mechanical property of the hydrogel is improved.

The present invention disclosed a cross-linked plugging agent stimulated by high density brine which comprises main agent: 10 wt %-90 wt %, gelling agent: 0.5 wt %-9 wt % and pure water; wherein the main agent is selected from the group consisting of a Dipotassium phosphate (K₂HPO₄), a Tripotassium phosphate (K₃PO₄) and a Potassium pyrophosphate (K₄P₂O₇), a Potassium Dihydrogen Phosphate (KH₂PO₄), a Sodium dihydrogen phosphate (NaH₂PO₄); the gelling agent is selected from the group consisting of a Xanthan gum and a kappa carrageenan. The gelling time is controlled within 0.5-12 h under an experiment temperature of 90° C.-160° C. The final gelling strength is controlled within D-H. The density is controlled within 1.0-1.55 g/cm³. The plugging agent is able to be applied in well completion and workover under high temperature, high pressure, multi-pressure series of strata oil and gas environment when temporary blockage and leak proof is required, protection of reservoir near perforations and water plugging.