31results about How to "Shorten the gelation time" patented technology

A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.

The invention discloses a super-molecular hydrogel double-medicament carrier for simultaneously loading hydrophilic and hydrophobic medicaments and a preparation method as well as application thereof. The method comprises the following operating steps of: performing chemical modification on the hydrophobic medicament by using methoxypolyethylene glycol to synthesize a water-soluble macromolecularprodrug; physically mixing prodrug molecules with the hydrophilic medicament; further mixing the mixed solution with an alpha-cyclodextrin solution and stirring; and standing at room temperature to obtain the super-molecular hydrogel double-medicament carrier for simultaneously loading the hydrophilic and the hydrophobic medicaments. The carrier has the advantages of easiness in operation, adjustable gel strength and gelation time, forming at room temperature, no chemical crosslinking reaction or organic solvent, high bioavailability, sustainable and controllable release of the medicament andthe like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention provides a cobalt-doped gel and a preparation method thereof. The preparation method is achieved by a sol-gel method combined with a technical route containing an acid catalytic hydrolysis and a base catalytic hydrolysis to prepare a cobalt-doped sol. The method is as below: preparing the raw materials of tetraethoxysilane and tributyl borate under the conditions of 60-70 DEG C, pH value of 3-5, and deionized water in substoichiometry into a silicon-boron sol; meanwhile, preparing a salt solution of alkali metal, aluminum and cobalt; adding the salt solution into the silicon-boron sol by multiple times, and further hydrolyzing the borosilicate sol under basic conditions to obtain a homogeneous cobalt-doped sol; and sealing the cobalt-doped sol and allowing to stand at 80-120 DEG C for gelation, aging and drying. By changing the composition and content of raw materials, the method can obtain the cobalt-doped gel with controllable compressive strength and half-life insurance of the cobalt-doped hollow glass microspheres.

The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying polymer, and gelation agent into a hydrocarbon reservoir. Delays of weeks are observed.

A method for preparing a titanium dioxide gel film electrochemical biosensor, which mainly consists of the following steps: Step 1, preparing TiO 2 Membrane: Soak the ITO electrode in 2-8mol / L sodium hydroxide solution for 5-12 hours, then immerse the electrode in 50-300mM butyl titanate solution for 2-5 minutes, then put the electrode into absolute ethanol Soak in water for 1-3 minutes, finally soak the electrode obtained in step 1.3 in secondary water for 1-3 minutes, step 2, immerse the electrode obtained in step 1 in the aqueous solution of enzyme (concentration: 2-4 mg / mL) for 30-120 A titanium dioxide gel membrane electrochemical biosensor is fabricated in minutes. The sensor prepared by the method of the present invention can reach the maximum response within 10s, and the detection limit of detecting hydrogen peroxide reaches 10 -6 mol / L, detection linear range is 2×10 -6 mol / L~3×10 -3 mol / L, and the sensor can be stored for 14 days without losing activity and can be reused.

The invention discloses a supramolecular structural hydrogel gene vector material and a preparation method and application thereof. The method comprises the following operation steps: synthesizing a multi-block copolymer with cation chain segments through modification of a terminal group of triblock copolymer of a polyethylene glycol-polypropylene glycol-polyethylene glycol which is modified by polylysine; then, mixing the copolymer with DNA solution to obtain DNA compound micelle; further, mixing and then stirring the micelle solution and solution of alpha-cyclodextrin; and keeping mixed solution at the room temperature to obtain hydrogel. The hydrogel can be used for preparing an injectable gene vector. The method has the advantages that the method has simple operation, can adjust the strength of the hydrogel and the gelatination time, can mold at the room temperature and does not relate to chemical crosslinking reaction and the use of organic solvent; and the obtained hydrogel has the advantages of temperature sensitivity, good bio-compatibility, obvious transfection effect and the like; and the method is hopeful to be widely applied in the field of a biomedical engineering material.

A sealing agent hydrogel, and a kit and preparation method therefor. The sealing agent hydrogel is prepared from the following raw material components: an electrophilic raw material as a first component; a nucleophilic material as a second component; a bioadhesive material as a third component, comprising 4-arm-PEG-DA; a physiological diluent as a fourth component, containing an alkaline buffer having a pH value of 7.5 to 12.5 and an acidic buffer having a pH value of 2.0 to 6.5. The sealing agent hydrogel features the addition of a chemically modified polyethylene glycol macromolecule monomer on the basis of a conventional two-component hydrogel, so that during use, a hydrogel which has a certain adhesion force is rapidly generated in situ after being mixed. The generated hydrogel features not only excellent biocompatibility, bioadhesion, biodegradability, and degradation performance adjustability, but also significantly shortened gelation time and significant improvements in important indicators such as gel content and swelling rate; and the degradation speed may be adjusted according to the requirements of an application scenario.

The object of the present invention is a composition in powder form comprising the following polysaccharides alginic acid or sodium alginate, - pectin, chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder. The process for preparing said powder by an atomization process and its use in the treatment of cutaneous wounds and in the sector of food preservation are additional objects of the invention. Moreover, additional objects of the invention are the composition in the form of solution or liquid suspension that represents the starting material to obtain said powder and the process for preparing said liquid composition.

The invention belongs to the field of biomedical materials and discloses a supramolecular hydrogel medicine and gene dual-carrier material and a preparation method thereof. The preparation method comprises the following steps: modifying end groups of a polyethylene glycol-polycaprolactone segmented copolymer, so as to synthetize a segmented copolymer containing cation chain segments; then mixing the polymer with a hydrophobic medicine solution, and further compounding with nucleic acid, thereby obtaining medicine-gene copolymer compound micelle; and further mixing the micelle solution with an alpha-cyclodextrin solution, stirring, and standing at a room temperature so as to obtain the hydrogel. The hydrogel can be used for preparing an injectable medicine gene carrier. The preparation method has the advantages of simplicity in operation, adjustable hydrogel strength and gelating time, molding at room temperature, and no use of chemical cross-linking reaction and organic solvents; the obtained hydrogel has the advantages of temperature sensibility, favorable biocompatibility, obvious transfection and the like, and is expected to be widely applied to the field of biomedical engineering materials.

The invention relates to the technical field of functional renovation of alginate fibers, in particular to an aquagel alginate fiber and a preparation method for the same. The preparation method for the aquagel alginate fiber comprises the following steps: (1) extracting a sodium alginate raw material from algae; (2) preparing an 8 to 10 mass percent aqueous solution of the alginate, and performing defoaming to obtain an alginate spinning solution; (3) preparing a mixed solution of an aqueous solution of soluble starch and the alginate spinning solution; (4) enabling the mixed solution obtained in step (3) to pass through a metering pump, and extruding the mixed solution into a first coagulating bath from a spinneret plate; (5) introducing as-spun fibers into a second coagulating bath; (6) introducing the fibers into a third coagulating bath, performing drawing forming, squeezing water out, and performing washing and drying to a constant weight, so as to obtain the aquagel alginate fibers. According to the aquagel alginate fiber and the preparation method, a preparation process is improved to improve the strength and the spinnability of the alginate fibers and shorten the gelation time, and the prepared aquagel alginate fiber can be used for preparing medical sanitary dressings and skin-care facial masks.

The invention provides a nanometer metal oxide and a preparation method thereof, and belongs to the field of nanometer inorganic compound photocatalytic materials and dyestuff manufacturing techniques. The present invention selects halides or inorganic salts containing metal ions as the source of metal ions, selects complexing agent, sucrose, glucose, acrylamide, bisacrylamide, agar, gelatin and carboxymethyl cellulose as gel raw materials, and evenly disperses the metal Ions, use industrial irradiation equipment to irradiate the raw material solution or emulsion to form a gel with a spatial network structure, and prepare nanoscale metal oxides through the later grinding and sintering processes. These nanoscale metal oxides can be used as excellent photocatalysts or dyes. The preparation method of the invention is simple, the process is stable, the operability is strong, the consumption of gel raw materials is greatly reduced, no heating is required, no special treatment of raw materials is required, and industrial irradiation devices can be used for mass production.