In situ gelifying powder

A technology of powder and pectin, which can be used in powder delivery, chemical preservation of meat/fish, drug combination, etc., and can solve problems such as shortening gelation time

Active Publication Date: 2020-06-19
MATERIAS SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] In particular, the inventors have addressed the problem of shortening the gelation time when the powder is placed in contact with a wound and improving the ability of the powder to absorb wound exudate
[0013] Furthermore, the inventors have addressed the problem of improving the adhesive capacity of gels formed in situ to avoid the risk of accidental peeling, while allowing easy removal of the gel from the wound after application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0267] Example 1 - Preparation of liquid composition

[0268] 1A) Aqueous composition (free of inorganic salts)

[0269] 1a) Preparation of sodium alginate solution

[0270] 53.6 mg of sodium alginate (whose mannuraldehyde residue content is 65% by weight relative to the total weight of sodium alginate) (FMC Biopolymer) was added to 21.4 ml of distilled water, and the solution was left under stirring for about 10 minutes.

[0271] 1b) Preparation of sodium alginate and pectin aqueous composition

[0272] To the sodium alginate solution prepared as described in a) was added 53.6 mg of amidated pectin (with a degree of amidation (DA) of 18% to 23% and a degree of methoxylation (DM) of 27% to 32%) (Herbstreith & Fox), the resulting solution was left under stirring for 15 minutes.

[0273] 1c) Preparation of colloidal chitosan solution

[0274] 8.9 mg of chitosan (with a molecular weight of 50000 to 150000 DA) (Sigma Aldrich) was added to 3.6 ml of a 0.1 M HCl solution in dist...

Embodiment 2

[0292] Example 2 - Preparation of the composition in powder form

[0293] 2A) Preparation of Compositions in Submicron Powder Form

[0294] Samples of each liquid composition obtained in Examples 1b (comparison), 1d and 1e (invention), respectively, were maintained under continuous agitation and dried with the aid of a Nano Spray Dryer B-90 instrument (BuchiLaboratoriums-Tecnik, Flawil , Switzerland) through nano-spray drying technology for atomization process. The inlet temperature in the atomizer for composition 1b (comparative) was 90°C, whereas for the particular composition 1d or 1e (invention) it was 50°C, ie advantageously lower.

[0295] The remaining process parameters were the same for both the comparative and inventive compositions, as follows:

[0296] - atomizer feed rate 9.5ml / min;

[0297] - The diameter of the atomizing nozzle is 4.0 microns;

[0298] - Incoming air flow 100L / min;

[0299] - a pressure of 38 mbar in the drying chamber;

[0300] - Relative...

Embodiment 3

[0326] Example 3 - Morphological analysis of the composition of the invention in powder form

[0327] Nanospray as described in Example 2A or 2B and the Compositions (2d1) and (2d2) in powder form according to the invention prepared by the micro-spray drying technique were analyzed. The powder particles were coated with 200A thick gold patina by means of a LEICA EMSCD005 metallizer. Analysis was performed at 20 KeV. At least 20 SEM images were obtained for each individual sample to verify the morphological uniformity of the particles.

[0328] like Figure 1A As shown in SEM analysis, the particles of the submicron-scale powder (2d1) have spherical shape and high surface roughness, which makes the particles easy to contact with liquid.

[0329] like Figure 1B As shown in the SEM analysis, the particles of the micron-sized powder (2d2) have a generally spherical shape and their surface roughness is lower than that of the sub-micron-sized powder (2d1).

[0330] Composition...

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Abstract

The object of the present invention is a composition in powder form comprising the following polysaccharides alginic acid or sodium alginate, - pectin, chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder. The process for preparing said powder by an atomization process and its use in the treatment of cutaneous wounds and in the sector of food preservation are additional objects of the invention. Moreover, additional objects of the invention are the composition in the form of solution or liquid suspension that represents the starting material to obtain said powder and the process for preparing said liquid composition.

Description

[0001] An object of the present invention is a composition in the form of an in situ gelifying powder; a further object of the present invention is a method for preparing said powder and said powder in the treatment of skin wounds and in food preservation use in the field. Furthermore, a further object of the present invention is to represent compositions in the form of solutions or liquid suspensions of starting materials for obtaining said powders, as well as methods for the preparation of such liquid compositions. Background technique [0002] The treatment of trauma is currently a worldwide problem. The market for products used to treat wounds is abundant, especially in developed countries such as the US, Europe and Japan, which together account for more than 80% of global sales, but in developing countries it is expected that the market will also be driven by healthcare services expansion and growth. Reference to 2014 epidemiological data shows that about 2% of the adul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/04C08L5/06C08L5/08A61K31/722A61K31/732A61K31/734A23L29/206A23L29/231A61K47/36
CPCA23L3/3463A61K45/06A61K31/65A61K31/722A61K31/732A61K31/734C08L5/04C08L5/06C08L5/08A23V2002/00A23L29/206A23L29/231A23L29/275A61P17/02A61K2300/00A23V2200/318A23V2250/5026A23V2250/5072A23V2250/511A23B4/20A23B4/22A23B4/24A23L3/34635A23L3/3544A23L3/358A61K9/08A61K9/146A61K9/1652A61K9/1682A61K47/36
Inventor 帕斯夸莱·德尔高迪奥丽塔·帕特里齐亚·阿基诺保拉·鲁索詹路易吉·德法尔科路易吉·尼古拉斯
Owner MATERIAS SRL
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