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A kind of sealing agent hydrogel and its kit and preparation method

A technology of hydrogel and sealant, which is applied in the field of biomedicine, can solve problems such as the need to improve the adhesion, and achieve the effects of avoiding the risk of disease transmission, broad application prospects, and reducing pain

Active Publication Date: 2020-10-09
BEIJING COMPONT MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many ways to prepare fast, shapeable gels, their adhesion needs to be improved

Method used

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  • A kind of sealing agent hydrogel and its kit and preparation method
  • A kind of sealing agent hydrogel and its kit and preparation method
  • A kind of sealing agent hydrogel and its kit and preparation method

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Experimental program
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Effect test

Embodiment 1

[0053] Embodiment 1: Preparation of sealant hydrogel

[0054] 1. Preparation method

[0055] According to the various components and parameters shown in Table 1, the first component was dissolved in acidic buffer to obtain solution I, the second component was dissolved in alkaline buffer to obtain solution II, and the third component was dissolved in in acidic buffer with NaIO 4 Solution III is obtained. Mix and cross-link solutions I, II and III, and quickly form the surgical sealant hydrogel of the present invention in situ at room temperature, and the specific gelation time is shown in Table 1; in addition, mix solutions I and II Ordinary cross-linked hydrogels can also be formed.

[0056] Wherein in the above-mentioned preparation method, the preparation method of the third component four-arm polyethylene glycol dopamine (4-arm-PEG-DA) is as follows: Weigh 0.5 mmol number-average molecular weight of four-arm polyethylene glycol succinyl For amine glutarate, add 20mL of...

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Abstract

A sealing agent hydrogel, and a kit and preparation method therefor. The sealing agent hydrogel is prepared from the following raw material components: an electrophilic raw material as a first component; a nucleophilic material as a second component; a bioadhesive material as a third component, comprising 4-arm-PEG-DA; a physiological diluent as a fourth component, containing an alkaline buffer having a pH value of 7.5 to 12.5 and an acidic buffer having a pH value of 2.0 to 6.5. The sealing agent hydrogel features the addition of a chemically modified polyethylene glycol macromolecule monomer on the basis of a conventional two-component hydrogel, so that during use, a hydrogel which has a certain adhesion force is rapidly generated in situ after being mixed. The generated hydrogel features not only excellent biocompatibility, bioadhesion, biodegradability, and degradation performance adjustability, but also significantly shortened gelation time and significant improvements in important indicators such as gel content and swelling rate; and the degradation speed may be adjusted according to the requirements of an application scenario.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a sealing agent hydrogel, a kit and a preparation method thereof. Background technique [0002] Surgical sealant, as a medical material that replaces surgical sutures, can be used in the fields of sealing hemostasis such as body surface, internal organs, cardiovascular and brain surgery, which can effectively shorten operation time, improve operation success rate, and reduce operation time. Therefore, it is a safe and effective treatment for patients and doctors. An ideal surgical sealant must meet the following conditions: good tissue compatibility, ability to be metabolized or biodegraded by the body, good bioadhesion, rapid film formation and solidification at room temperature to form a water-insoluble Membranes etc. [0003] Natural mussels tend to have a strong adhesive force, and mussel-based biomimetic adhesives have been potential biomedical materials. Studies have shown tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/04C08J3/075C08J3/24C08L71/02C08L79/02
CPCA61L24/001A61L24/0031A61L24/043C08J3/075C08J3/246C08J2371/02C08J2471/02C08J2479/02C08L71/02C08L79/02
Inventor 沈伟伍国琳单萌
Owner BEIJING COMPONT MEDICAL DEVICES
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