Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof

A foam aerosol and temperature-sensitive gel technology, which can be used in aerosol delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of wide coating area, excellent curative effect and good permeability

Inactive Publication Date: 2009-07-29
广州万泽医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The propellant used in the nano-silver spray in this patent is selected from dichlorodifluoromethane, dichlorotetrafluoroethane, propane, butane or a mixture thereof, wherein dichlorodifluoromethane and dichlorotetrafluoroethane are Chlorofluoroalkane (CFC) compounds will damage the ozone layer of the atmosphere, are not environmentally friendly, and are prohibited by relevant international conventions; while propane and butane have disadvantages such as low boiling point and flammability, they are not suitable for use as propellants for medicines

Method used

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  • Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof
  • Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of temperature-sensitive gel-type nano silver foam aerosol 1:

[0030] Prepare temperature-sensitive gel-type nano silver foam aerosol according to the following steps and corresponding component ratios:

[0031] Step 1. Accurately measure distilled water, place it in an ice water bath, and slowly add accurately weighed Poloxamer 407 and Poloxamer 188 while stirring to make Poloxamer 407 and Poloxamer 188 The particles are wetted by water;

[0032] Step 2: Store the mixed solution in Step 1 in a refrigerator at 4°C until a clear, clump-free, and uniformly dispersed solution is obtained.

[0033] Step 3: Add nano silver colloid, glycerin, and ethyl paraben to the solution in step 2; stir and mix uniformly to form a gel.

[0034] The ratio of each component is:

[0035] Nano silver colloid 175mL

[0036] Poloxamer 407 200g

[0037] Poloxamer 188 60g

[0038] Glycerin 10g

[0039] Ethyl Paraben 1g

[0040]

[0041] Add distilled wate...

Embodiment 2

[0046] Preparation of temperature-sensitive gel-type nano silver foam aerosol 2:

[0047] The temperature-sensitive gel-type nano silver foam aerosol was prepared according to the steps in Example 1, and the ratio of each component was adjusted as follows:

[0048] Nano silver colloid 175mL

[0049] Poloxamer 407 200g

[0050] Poloxamer 188 90g

[0051] Glycerin 10g

[0052] Ethyl Paraben 1g

[0053]

[0054] Add distilled water to make up to 1000mL

[0055] In step four, the propellant dimethyl ether with a volume ratio of 8% was filled in the cans, and the sources of the various components used in the preparation process were the same as in Example 1.

Embodiment 3

[0057] Preparation of temperature-sensitive gel-type nano silver foam aerosol 3:

[0058] The temperature-sensitive gel-type nano silver foam aerosol was prepared according to the steps in Example 1, and the ratio of each component was adjusted as follows:

[0059] Nano silver colloid 175mL

[0060] Poloxamer 407 220g

[0061] Poloxamer 188 90g

[0062] Glycerin 10g

[0063] Ethyl Paraben 1g

[0064]

[0065] Add distilled water to make up to 1000mL

[0066] In step four, the propellant dimethyl ether with a volume ratio of 15% was filled in the cans, and the sources of the various components used in the preparation process were the same as in Example 1.

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Abstract

The invention relates to a temperature-sensitive gel type nano-silver foam aerosol for women, which comprises a gel system and a propellant dimethyl ether evenly mixed in the gel system, wherein the gel system contains nano-silver colloidal particles, a temperature-sensitive high molecular polymer and a diluting agent. The volume of the propellant the dimethyl ether is 8 to 15 percent of that of the gel system. An ejected matter is foam during the use of the temperature-sensitive gel type nano-silver foam aerosol, the deep administration can be performed, and a medicine can quickly swell and comprehensively contacts a focus after reaching the focus, and is dispersed evenly and permeated fully in a cavity; and at the same time, the nano-silver foam aerosol forms semisolid shaped gel in special physiological environment of a drug application position, has strong adhesiveness, is convenient for vagina mucosa to absorb to play effect, and effectively improves the compliance of patients and the bioavailability of nano-silver. The temperature-sensitive gel type nano-silver foam aerosol for the women has the advantages of convenient use, exact therapeutic effect, and no drug dependence.

Description

Technical field [0001] The invention relates to a medicine for treating and preventing gynecological diseases and a preparation method thereof, in particular to a temperature-sensitive gel-type nano silver foam aerosol for women and a preparation method thereof. Background technique [0002] Nano-silver is a kind of ultra-micro size material (usually 10~100nm) that came into being with the rise of nanotechnology and nanomaterial research. Due to quantum effect, small size effect and macroscopic tunneling effect, it has strong activity and tissue penetration Its bactericidal effect is far stronger than ordinary silver and silver ions. Studies have shown that the antibacterial properties of nano-silver particles are far more effective in killing pathogenic bacilli, cocci and filamentous fungi than traditional silver ion fungicides, such as silver nitrate and silver sulfadiazine. In addition, from the analysis of the antibacterial mechanism of nano-silver, due to the surface electro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/12A61K47/36A61P15/00A61P15/02
Inventor 吴传斌陈美婉
Owner 广州万泽医药科技有限公司
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