Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof
A foam aerosol and temperature-sensitive gel technology, which can be used in aerosol delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of wide coating area, excellent curative effect and good permeability
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Embodiment 1
[0029] Preparation 1 of temperature-sensitive gel-type nano-silver foam aerosol:
[0030] Prepare temperature-sensitive gel-type nano-silver foam aerosol according to the following steps and corresponding component ratios:
[0031] Step 1. Accurately measure distilled water, place it in an ice-water bath, and slowly add accurately weighed Poloxamer 407 and Poloxamer 188 while stirring to make Poloxamer 407 and Poloxamer 188 The particles are wetted by water;
[0032] Step 2. Store the mixed solution in step 1 in a refrigerator at 4° C. until a clear, lump-free, and uniformly dispersed solution is obtained.
[0033] Step 3: Add nano-silver colloid, glycerin, and ethylparaben to the solution in step 2; stir and mix evenly to form a gel.
[0034] Wherein the proportioning ratio of each component is:
[0035] Nano Silver Colloid 175mL
[0036] Poloxamer 407 200g
[0037] Poloxamer 188 60g
[0038]Glycerin 10g
[0039] Ethylparaben 1g
[0040] Add distilled water to make up...
Embodiment 2
[0045] Preparation of temperature-sensitive gel-type nano-silver foam aerosol 2:
[0046] Prepare thermosensitive gel type nano-silver foam aerosol by the step in embodiment 1, the proportioning adjustment of each component is:
[0047] Nano Silver Colloid 175mL
[0048] Poloxamer 407 200g
[0049] Poloxamer 188 90g
[0050] Glycerin 10g
[0051] Ethylparaben 1g
[0052] Add distilled water to make up to 1000mL
[0053] In step 4, the propellant dimethyl ether with a volume ratio of 8% can be filled, and the sources of various components used in the preparation process are the same as those in Example 1.
Embodiment 3
[0055] Preparation of temperature-sensitive gel-type nano-silver foam aerosol 3:
[0056] Prepare thermosensitive gel type nano-silver foam aerosol by the step in embodiment 1, the proportioning adjustment of each component is:
[0057] Nano Silver Colloid 175mL
[0058] Poloxamer 407 220g
[0059] Poloxamer 188 90g
[0060] Glycerin 10g
[0061] Ethylparaben 1g
[0062] Add distilled water to make up to 1000mL
[0063] In step 4, the propellant dimethyl ether with a volume ratio of 15% is filled in a tank, and the sources of various components used in the preparation process are the same as those in Example 1.
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