Preparation method of injectable self-adaptive natural hydrogel adhesive

Abstract

The invention provides a preparation method of an injectable self-adaptive natural hydrogel adhesive. The preparation method comprises the following steps: firstly, synthesizing gelatin-phenylboronic acid from carboxyl phenylboronic acid and gelatin through an amidation reaction, or synthesizing polysaccharide-phenylboronic acid from amino phenylboronic acid and natural polysaccharide; synthesizing gelatin-dopamine or polysaccharide-dopamine from dopamine and gelatin or natural polysaccharide through an amidation reaction; and dissolving the gelatin-phenylboronic acid / polysaccharide-phenylboronic acid in a phosphate buffer solution, dissolving the gelatin-dopamine / polysaccharide-dopamine in a phosphate buffer solution containing natural polyphenol substances, and uniformly mixing two obtained solutions to realize a spontaneous esterification reaction of phenylboronic acid and polyphenol so as to generate reversible boric acid ester bonds, thereby finally preparing the injectable self-adaptive natural hydrogel adhesive. The hydrogel adhesive disclosed by the invention has good biological adhesion and antibacterial and anti-inflammatory effects, and is attached to the surface of a tissue to play a repairing role; and the hydrogel adhesive has good mechanical self-adaptive performance and can be matched with deformation and frequency of different dynamic tissues.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of an injectable self-adaptive natural hydrogel adhesive for repairing lung damage. Background technique [0002] Pneumothorax (pneumothorax) refers to the gas into the pleural cavity, resulting in a state of pneumothorax, known as pneumothorax. The lung tissue and visceral pleura are usually ruptured due to lung disease or external force, or the tiny emphysema bubbles near the lung surface are ruptured, and the air in the lungs and bronchi escapes into the pleural cavity. Generally speaking, those caused by chest wall or lung trauma are called traumatic pneumothorax; those caused by spontaneous rupture of lung tissue due to disease are called "spontaneous pneumothorax". The incidence of traumatic pneumothorax accounts for 15% to 50% in blunt trauma and 30% to 87.6% in penetrating trauma. Mostly because the lung is punctured by the broken end of t...

AI Technical Summary

Problems solved by technology

There is no clinically effective method for repairing damaged lung tissue. The main reasons are as follows: (1) The lung tissue cannot be sutured with surgical needles and threads, because it will cause new air leakage points; (2) The lung tissue is soft and dynamic. The contraction-expansion entity, the mechanical hardness of the existing medical adhesive is too large, and the adhesion on the surface of the lung tissue cannot adapt to the dynamic change of the lung surface deformation, resulting in uncoordinated local deformation and excessive strain, which may cause Additional lung function damage; (3) The cost of thoracotomy is high, the patient is damaged greatly, and the operation is difficult. Even with minimally invasive surgery, the wound is still much larger than that of acupuncture or catheter