Temperature-sensitive calcium phosphate bone cement and preparation method thereof

A calcium phosphate bone cement, temperature-sensitive technology, applied in the field of biomedical engineering, can solve the problems of low mechanical properties, poor degradation resistance, cytotoxicity of β-glycerophosphate disodium, etc.

Active Publication Date: 2020-04-17
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, chitosan / β-glycerophosphate disodium hydrogel is used to prepare temperature-sensitive slip cement, but there are still some defects, such as low mechanical properties and poor degradation resistance in vivo, which limits its performance. application, and disodium β-glycerophosphate is cytotoxic

Method used

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  • Temperature-sensitive calcium phosphate bone cement and preparation method thereof
  • Temperature-sensitive calcium phosphate bone cement and preparation method thereof
  • Temperature-sensitive calcium phosphate bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A temperature-sensitive calcium phosphate bone cement, comprising a solid phase powder and a liquid phase component, the mass ratio of the solid phase powder to the liquid phase component is: 1.5:1;

[0038] The solid phase powder is α-tricalcium phosphate;

[0039] The liquid phase components are prepared by the following method:

[0040] Configuration mass fraction is 4% gamma-glycidyl etheroxypropyl trimethoxysilane;

[0041] Configuration mass fraction is 3% chitosan acetic acid aqueous solution: dissolving chitosan in 1wt% acetic acid solution is made into mass fraction is 3% chitosan acetic acid aqueous solution, wherein chitosan is deacetylated 90% Chitosan powder with a molecular weight of 700,000;

[0042] The preparation mass fraction is the sodium glycerophosphate solution of 50%;

[0043] The preparation mass fraction is 10% bletilla striata polysaccharide solution;

[0044] Mix Bletilla striata polysaccharide solution, γ-glycidyl etheroxypropyl trimetho...

Embodiment 2

[0046] A temperature-sensitive calcium phosphate bone cement, comprising solid phase powder and liquid phase components, the mass ratio of solid phase powder and liquid phase components is: 2:1;

[0047] The solid phase powder is α-tricalcium phosphate;

[0048] The liquid phase components are prepared by the following method:

[0049] Configuration mass fraction is 6% gamma-glycidyl etheroxypropyl trimethoxysilane;

[0050]Configuration mass fraction is 5% chitosan acetic acid aqueous solution: dissolving chitosan in 1wt% acetic acid solution is made into mass fraction is 5% chitosan acetic acid aqueous solution, wherein chitosan is deacetylated 90% Chitosan powder with a molecular weight of 700,000;

[0051] The preparation mass fraction is the sodium glycerophosphate solution of 60%;

[0052] The preparation mass fraction is 20% bletilla striata polysaccharide solution;

[0053] Mix Bletilla striata polysaccharide solution, γ-glycidyl etheroxypropyl trimethoxysilane, ch...

Embodiment 3

[0055] A temperature-sensitive calcium phosphate bone cement, comprising a solid phase powder and a liquid phase component, the mass ratio of the solid phase powder to the liquid phase component is: 2.7:1;

[0056] The solid phase powder is α-tricalcium phosphate;

[0057] The liquid phase components are prepared by the following method:

[0058] Configuration mass fraction is 5% gamma-glycidyl etheroxypropyl trimethoxysilane;

[0059] Configuration mass fraction is 4% chitosan acetic acid aqueous solution: dissolving chitosan in 1wt% acetic acid solution is made into mass fraction is 4% chitosan acetic acid aqueous solution, wherein chitosan is deacetylated 90% Chitosan powder with a molecular weight of 800,000;

[0060] Preparation mass fraction is 40% sodium glycerophosphate solution;

[0061] The preparation mass fraction is 15% bletilla striata polysaccharide solution;

[0062] Mix Bletilla striata polysaccharide solution, γ-glycidyl etheroxypropyl trimethoxysilane, c...

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Abstract

The invention discloses temperature-sensitive calcium phosphate bone cement and a preparation method thereof. The temperature-sensitive calcium phosphate bone cement comprises solid-phase powder and aliquid-phase component. The solid-phase powder is calcium salt. The liquid-phase component is prepared by mixing the following components: a gamma-glycidyl ether oxypropyl trimethoxysilane aqueous solution, a chitosan acetic acid aqueous solution, a sodium glycerophosphate aqueous solution and a bletilla striata polysaccharide aqueous solution. According to the temperature-sensitive calcium phosphate bone cement, a temperature-sensitive bone cement system prepared from chitosan, beta-disodium glycerophosphate and alpha-tricalcium phosphate is adopted and sol-gel conversion temperature sensitization is realized by regulating and controlling the interaction between the temperature-sensitive calcium phosphate bone cement and water molecules. After component optimization, the beta-sodium glycerophosphate is reduced, the toxicity is reduced, the gelation time of the hydrogel is shortened, the mechanical property of the bone cement is enhanced, the collapse resistance is improved, and the defect of poor mechanical property of the hydrogel is improved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a temperature-sensitive calcium phosphate bone cement and a preparation method thereof. Background technique [0002] Calcium phosphate bone cement forms hydroxyapatite when it meets water. It is biocompatible and forms a mass with sufficient strength after self-curing. It can be plasticized according to needs. It can be used in orthopedics and dentistry for filling bone defects. Root canal filling, etc. After bone cement implantation, the bone cement can be absorbed and replaced by newly generated bone without degrading the volume of the implant and maintaining the integrity of the implant material. [0003] The aqueous solution of thermosensitive hydrogel is in a free-flowing sol state at low temperature. As the temperature increases, a phase transition from sol to gel occurs at a specific temperature, forming a dense gel network structure. In the prior art, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/50A61L27/58
CPCA61L27/12A61L27/20A61L27/50A61L27/58A61L2400/06C08L5/08C08L5/00
Inventor 车七石单玲星刘少辉张俊辉赵澎
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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