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Temperature-sensitive hydrogel as well as preparation method and application thereof

A temperature-sensitive hydrogel and solution technology, applied in medical science, bandages, etc., can solve the problems of long gelation time and poloxamer application limitations, achieve good water absorption performance, shorten gelation time, and reduce bacteria Effect of infection

Pending Publication Date: 2022-08-05
和携科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, poloxamer has a great dependence on the concentration, and the hydrogel needs to reach a certain concentration before forming a hydrogel, and the gelation time is longer, which limits the application of poloxamer.

Method used

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  • Temperature-sensitive hydrogel as well as preparation method and application thereof
  • Temperature-sensitive hydrogel as well as preparation method and application thereof
  • Temperature-sensitive hydrogel as well as preparation method and application thereof

Examples

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preparation example Construction

[0057] The application also provides a preparation method of the above-mentioned thermosensitive hydrogel, which specifically includes the following steps:

[0058] S1, get the chitosan solution in the biological solution, add acid while stirring, stir and mix to obtain the first solution;

[0059] S2, get poloxamer 407 in the biological solution, stir and mix to obtain the second solution;

[0060] S3, take silicon-modified polyacrylamide and biological solvent, stir and mix evenly to obtain a third solution;

[0061]S4, the second solution and the third solution are uniformly mixed to obtain the fourth solution;

[0062] S5, mixing the first solution and the fourth solution uniformly to prepare a temperature-sensitive hydrogel solution.

[0063] In the present invention, the first solution, the second solution and the third solution are prepared by dissolving chitosan, poloxamer 407 and silicon-modified polyacrylamide in the biological solution respectively, and then mixin...

Embodiment 1

[0070] Embodiment 1: Organosilicon monomer and its preparation method

[0071] The present embodiment provides an organosilicon monomer, which is prepared from octamethylcyclotetrasiloxane as a starting material, and specifically includes the following steps:

[0072] S1. Add 1,1,3,3-tetramethyldisiloxane and octamethylcyclotetrasiloxane into a three-necked flask, add a sulfuric acid solution with a concentration of 86wt%, and stir at room temperature for 20h;

[0073] S2, stand and separate to obtain water layer, add excess sodium bicarbonate to neutralize;

[0074] S3, suction filtration, and distillation under reduced pressure at 150° C. to obtain an organosilicon monomer.

[0075] Among them, the input ratio of 1,1,3,3-tetramethyldisiloxane and octamethylcyclotetrasiloxane is 1:25, and the amount of sulfuric acid solution added is the mass of octamethylcyclotetrasiloxane 3%.

Embodiment 2

[0076] Example 2: Silicon-modified polyacrylamide and its preparation method

[0077] Polyacrylamide refers to the homopolymer of acrylamide, which is a linear polymer and has good solubility in water. The role of Sham 407 gel, and its preparation specifically includes the following steps:

[0078] S1. Dissolve acrylamide and organosilicon monomers in toluene, and stir at room temperature until completely dissolved;

[0079] S2, pass nitrogen to remove oxygen, heat up to 65°C, and add Karstedts catalyst;

[0080] S3, continue to heat up to 85 ℃, react 10h;

[0081] S4, adding acetone, soaking, suction filtration, washing and drying in vacuum to obtain silicon-modified polyacrylamide white powder;

[0082] Wherein, the organosilicon monomer was prepared by the method provided in Example 1.

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Abstract

The invention discloses temperature-sensitive hydrogel as well as a preparation method and application thereof, and relates to the field of pharmaceutical preparations. The temperature-sensitive hydrogel is prepared from poloxamer 407, chitosan, silicon modified polyacrylamide, a biological solution and acid. The method has the effect of shortening the gelation time of the poloxamer.

Description

technical field [0001] The present application relates to the field of pharmaceutical preparations, in particular to a thermosensitive hydrogel, a preparation method and applications thereof. Background technique [0002] Hydrogel refers to a class of substances that are cross-linked by polymer substances through chemical bonds or intermolecular interactions to form a three-dimensional network structure. It has the mobility and fluidity of liquids and the dimensional stability of solids. [0003] Smart hydrogels are hydrogels that have the ability to sense certain signals and stimuli changes in the external environment. According to the sensed signals, they can be divided into pH-sensitive hydrogels, temperature-sensitive hydrogels, compound-sensitive hydrogels and Types of light-sensitive hydrogels, etc. Among them, temperature-sensitive hydrogels are mainly composed of macromolecular substances, hydrophilic groups and hydrophobic groups. They can undergo phase transition...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0014A61L26/0028A61L26/0057A61L26/0076A61L26/0066A61L2300/412A61L2300/30A61L2300/252C08L71/02C08L33/26C08L89/00Y02A50/30
Inventor 杨桂花杨海霞赵进军
Owner 和携科技有限公司
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