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Antibacterial supermolecule aquogel and preparation method and application thereof

A supramolecular hydrogel, antibacterial technology, applied in the field of biomedical engineering materials, to achieve the effect of avoiding residue, good shear thinning, low concentration and temperature requirements

Inactive Publication Date: 2009-10-28
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the in situ preparation and application of nanosilver-containing antibacterial gels through host-guest interactions between polymers and cyclodextrins has not been reported

Method used

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  • Antibacterial supermolecule aquogel and preparation method and application thereof
  • Antibacterial supermolecule aquogel and preparation method and application thereof
  • Antibacterial supermolecule aquogel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Dissolve 0.05g of polyethylene glycol-polypropylene glycol-polyethylene glycol (PluronicF-68) in 0.95g of water at room temperature 25°C to make 5% polyethylene glycol-polypropylene glycol-polyethylene glycol Glycol triblock copolymer solution solution; 5.0 mg of silver nitrate crystals are added to 1.0 mL of the above-mentioned copolymer solution, stirred to dissolve the crystals, and obtain a mixed solution of polymer and silver nitrate;

[0038] (2) At room temperature, the mixed solution obtained in step (1) is alternately carried out for 2 hours by magnetically stirring at 300 rpm for 15 minutes and ultrasonically dispersing at 90KHz ultrasonic frequency for 5 minutes according to the rotating speed of the mixed solution obtained in step (1), to obtain a stable dispersed nano-silver sol ;

[0039] (3) Add 1.0 mL of α-cyclodextrin solution with a mass percent concentration of 15% to the nano-silver sol obtained in step (2), stir and mix evenly, and let stand at ...

Embodiment 2

[0041](1) Dissolve 0.10g of polyethylene glycol-polypropylene glycol-polyethylene glycol (PluronicF-68) in 0.90g of water at room temperature 25°C to make 10% polyethylene glycol-polypropylene glycol-polyethylene glycol Diol tri-block copolymer solution; 5.0 mg of silver nitrate crystals were added to 1.0 mL of the above-mentioned copolymer solution, stirred to dissolve the crystals, and a mixed solution of polymer and silver nitrate was obtained;

[0042] (2) At room temperature, the mixed solution obtained in step (1) is alternately carried out for 2 hours by magnetically stirring at 300 rpm for 15 minutes and ultrasonically dispersing at 90KHz ultrasonic frequency for 5 minutes according to the rotating speed of the mixed solution obtained in step (1), to obtain a stable dispersed nano-silver sol ;

[0043] (3) Add 1.0 mL of α-cyclodextrin solution with a mass percent concentration of 15% to the nano-silver sol obtained in step (2), stir and mix evenly, and let stand at roo...

Embodiment 3

[0045] (1) Dissolve 0.20g of polyethylene glycol-polypropylene glycol-polyethylene glycol (PluronicF-68) in 0.80g of water at room temperature 25°C to make 20% polyethylene glycol-polypropylene glycol-polyethylene glycol Diol tri-block copolymer solution; 5.0 mg of silver nitrate crystals were added to 1.0 mL of the above-mentioned copolymer solution, stirred to dissolve the crystals, and a mixed solution of polymer and silver nitrate was obtained;

[0046] (2) At room temperature, the mixed solution obtained in step (1) is alternately carried out for 2 hours by magnetically stirring at 300 rpm for 15 minutes and ultrasonically dispersing at 90KHz ultrasonic frequency for 5 minutes according to the rotating speed of the mixed solution obtained in step (1), to obtain a stable dispersed nano-silver sol ;

[0047] (3) Add 1.0 mL of α-cyclodextrin solution with a mass percent concentration of 15% to the nano-silver sol obtained in step (2), stir and mix evenly, and let stand at ro...

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Abstract

The invention discloses a method for in-situ preparing antibacterial supermolecule aquogel. The method comprises the following operation steps: silver nitrate crystal and polyethyleneglycol-polypropylene glycol-polyethyleneglycol triblock copolymer solution are mixed and stirred to obtain mixed solution; the steps of stirring the mixed solution for 15 minutes and ultrasonically dispersing the mixed solution for 5 minutes are alternatively carried out for 2-4 hours to obtain nano silver sol; and the nano silver sol and Alpha-cyclodextrin solution are mixed, stirred and stands at the room temperature to obtain hydrogel. The hydrogel can be used for preparing injectable drug carriers. The invention has the advantages of simple operation, adjustable gel strength and the gelation time, room temperature forming, no involvement of chemical cross linking reaction and the usage of organic solvent, favorable biocompatibility and antibacterial property of obtained gel, and the like and is prospective to be widely applied in the field of biomedical engineering materials.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, in particular to an antibacterial supramolecular hydrogel and its preparation method and application. Background technique [0002] Cyclodextrin-based supramolecular hydrogels formed through host-guest assembly have attracted much attention for their potential applications in tissue engineering, drug delivery, and controlled release. This kind of gel material is a gel material with a supramolecular structure formed by assembling cyclodextrin and a polymer containing polyethylene glycol chain segments through host-guest interaction. The preparation conditions are mild, the temperature and concentration are low, no organic solvent is involved, the sol-gel is reversible, and it can be used as a new type of injectable gel for the loading and release of drug molecules. At the same time, the large number of hydroxyl groups on the cyclodextrin molecule provides the possibility for furthe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K47/40A61K47/34A61K9/00A61P31/04A61K47/10
Inventor 马栋谢曦张黎明
Owner SUN YAT SEN UNIV
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