High-strength supramolecular hydrogel and preparation method and application thereof

A supramolecular hydrogel, high-strength technology, used in medical science, prosthesis, etc., can solve the problems of high tensile and anti-compression functions, and achieve good biocompatibility, strong tensile, and good mechanical strength. and the effect of toughness

Inactive Publication Date: 2015-07-29
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But these high-strength hydrogels do not have both high tensile and compressive properties (Yoshimi Tanaka, Jain Ping Gong, Yoshihito Osada. Novel hydrogels with excellent mechanical performance. (MMC)
But these h

Method used

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  • High-strength supramolecular hydrogel and preparation method and application thereof
  • High-strength supramolecular hydrogel and preparation method and application thereof
  • High-strength supramolecular hydrogel and preparation method and application thereof

Examples

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Embodiment Construction

[0021] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0022] In the examples, glycinamide hydrochloride and acryloyl chloride were used as raw materials according to references (Boustta M, Colombo P E, Lenglet S, et al. Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery[J]. Journal of Controlled Release, 2014, 174:1-6) prepared a monomer acryloyl glycinamide with two amide groups, the chemical formula structure is shown in the following chemical formula:

[0023]

[0024] Utilize Fourier transform infrared spectroscopy (U.S. Platinum Elmer Company) to prove its successful synthesis, wherein their characteristic peaks are as follows: ν=3389cm -1 (m,NH),3314cm -1 (s,NH),3191cm -1 (m,NH),1662cm -1 (vs, C=O), 1626cm -1 (vs, C=O), 1556cm -1 (vs, NH) (see attached figure 1 ).

[0025] Carry out homopolymerization with the acryloyl glycinamide synthesized abo...

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Abstract

The invention discloses a high-strength supramolecular hydrogel and a preparation method and application thereof. The high-strength supramolecular hydrogel is prepared by using acryloyl glycinamide as a monomer and triggering in the presence of an initiator; because of the synergistic effect of hydrogen bonds, the supramolecular hydrogel is high in tensile strength and anti-tear while being compressed, can realize functions of thermoplasticity and self-repair at a high temperature, and is good in biocompatibility.

Description

technical field [0001] The present invention relates to a kind of hydrogel and its preparation method, more specifically, relate to a kind of PNAGA hydrogel prepared with acryloyl glycinamide (NAGA) as a monomer and its preparation method, which has high stability, high strength, Thermoplastic and self-healing capabilities. Background technique [0002] Hydrogel is a polymer material with cross-linked structure, which is hydrophilic but water-insoluble and can absorb a large amount of water (usually the water content is greater than 50% of the total mass) with water as the dispersion medium. Because of the physical crosslinking and chemical crosslinking between polymer chains, it will not dissolve in water, but can only swell and maintain a certain shape. At the same time, it also has good water permeability and biocompatibility. It can be used as a human implant Can reduce adverse reactions. Therefore, hydrogels have been widely used as excellent biomedical materials. Ho...

Claims

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Application Information

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IPC IPC(8): C08F120/36C08J3/075A61L27/16A61L27/38A61L27/52
CPCA61L27/16A61L27/3817A61L27/50A61L27/52C08F120/36C08F122/38C08J3/075C08J2333/14C08J2335/00C08L33/14C08L35/00
Inventor 刘文广戴西洋张银宇
Owner TIANJIN UNIV
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