Injected supermolecule hydrogel and preparing method thereof

A hydrogel, injection-type technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of inability to verify the mechanism of inorganic-organic hybridization, inability to directly prove the hybridization reaction, etc., and achieve super injectable performance. , Controllable mechanical properties and degradation properties, excellent mechanical properties

Inactive Publication Date: 2016-06-15
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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Problems solved by technology

However, due to the limitations of FTIR technology, the results cannot directly prove the occurrence of the hybridization reaction, and the material is only prepared into a two-dimensional structure, and the research is still in the preliminary stage of exploratory research.
However, most foreign studies only predict the molecular structure of the hybrid they prepared, and only use FTIR to detect the type of covalent bond, which cannot verify the inorganic-organic hybrid mechanism of the hybrid

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  • Injected supermolecule hydrogel and preparing method thereof

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[0020] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0021] combine figure 1 , the embodiment of the present invention provides an injectable hydrogel, including β-cyclodextrin, gelatin and a coupling agent, the β-cyclodextrin and the benzene ring in the gelatin interact with the host and guest through the hydrophobic interaction Combining, the gelatin and one end of the coupling agent containing amino or epoxy bonds form a covalent crosslink, and the other end of the coupling agent spontaneously crosslinks to form a silica network.

[0022] In the supramolecular hydrogel provided by the embodiment of the present invention, various substance...

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Abstract

The invention belongs to the technical field of hydrogel and provides injected supermolecule hydrogel and a preparing method thereof. The injected supermolecule hydrogel comprises beta-cyclodextrin, gelatin and a coupling agent. Beta-cyclodextrin and a benzene ring in gelatin are combined in a subject and object mode by means of the hydrophobicity effect. The coupling agent is a silane coupling agent containing amino and/or epoxy bonds. Gelatin and the end, containing amino or epoxy bonds, of the coupling agent form covalent cross linking. The other end of the coupling agent is subjected to self-crosslinking to form a silicon dioxide network.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, in particular to an injectable supramolecular hydrogel and a preparation method thereof. Background technique [0002] Cartilage defect is a common clinical orthopedic disease, arthroscopy found that about 60% of the joints have cartilage defects. If not treated in time, 60%-75% of the lesions can progressively develop into osteoarthritis, seriously affecting the patient's motor function, and even ending his career. Since articular cartilage is not vascularly innervated, its regenerative capacity is very limited. Therefore, in the fields of biomaterials and medicine, cartilage defect repair has always been a research hotspot. So far, cartilage defect repair has not been effectively solved. As the gold standard for the treatment of articular cartilage defects, autologous chondrocyte transplantation has been recognized by scholars, but there are problems such as limited source of seed cells an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/02A61L27/22A61L27/50A61L27/58
CPCA61L27/02A61L27/20A61L27/222A61L27/50A61L27/58A61L2430/06
Inventor 王大明王大平刘威朱伟民段莉黄江鸿梁宇杰刘启颂熊建义
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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