Supramolecular hydrogel microsphere prepared by taking liquid drop as template and preparation method thereof

A supramolecular hydrogel and droplet technology, which can be used in the preparation of microspheres, inactive components of polymer compounds, microcapsule preparations, etc., can solve problems such as lack and achieve the effect of high monodispersity index

Inactive Publication Date: 2015-01-07
NANJING WISDOM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current method of supramolecular assembly is limited to macroscopic bulk materials with a size of millimeter or centimeter, and there is still a lack of reliable methods for preparing supramolecular hydrogel microspheres with a size of microns; at the same time, how to control the prepared supramolecular water The size uniformity of gel microspheres is also a key issue that researchers need to solve urgently

Method used

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  • Supramolecular hydrogel microsphere prepared by taking liquid drop as template and preparation method thereof
  • Supramolecular hydrogel microsphere prepared by taking liquid drop as template and preparation method thereof
  • Supramolecular hydrogel microsphere prepared by taking liquid drop as template and preparation method thereof

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Embodiment 1

[0034] like image 3 As shown, in the first example of a method for preparing supramolecular hydrogel microspheres using droplets as templates in the present invention, droplet microfluidic chip technology is used to form monodisperse water-in-oil droplets. The structure of the microfluidic chip used in the preparation is as follows image 3 As shown, it includes 3 inlets and 1 outlet, all connected by plastic micro-catheter. The three inlets are respectively used for the discontinuous phase (30% mass fraction of β-cyclodextrin modified poly(hydroxyethyl methacrylate-acrylamide) CD-PHEMA-PAM aqueous solution and 30% mass fraction of adamantane modified Poly(hydroxyethyl methacrylate-acrylamide copolymer Ad-PHEMA-PAM aqueous solution) and continuous phase (3M FC40 fluorine oil) were injected, and the outlet was used for product collection. Keep the flow rate of CD-PHEMA-PAM aqueous solution and Ad-PHEMA-PAM aqueous solution in the channel of the microfluidic chip at 200 μL / h,...

Embodiment 2

[0036] The realization process of doxorubicin entrapment is as follows: Figure 5 shown. The difference between this example and Example 1 is that the number of inlets of the microfluidic chip is increased to 4, and the aqueous solution of doxorubicin with a mass fraction of 0.1% is injected into the microfluidic channel at a rate of 100 μL / h, keeping the mass fraction at 30% The flow rate of CD-PHEMA-PAM aqueous solution and 30% Ad-PHEMA-PAM aqueous solution in the microfluidic chip channel is 200 μL / h, and the flow rate of FC40 fluorine oil in the microfluidic chip channel is 800 μL / h Finally, under the shear action of FC40 fluorine oil and the host-guest assembly action, doxorubicin-embedded supramolecular hydrogel monodisperse microspheres were formed.

Embodiment 3

[0038] like Figure 6 As shown, in the third example of a method for preparing supramolecular hydrogel microspheres using droplets as templates in the present invention, the formation of droplets adopts the spray droplet formation technology. 50% β-cyclodextrin-modified polyvinylpyrrolidone-acrylamide copolymer CD-PVP-PAM aqueous solution, 50% adamantane-modified polyhydroxyethyl methacrylate-acrylamide copolymer The blend of Ad-PHEMA-PAM aqueous solution and 0.1% paclitaxel was injected into the spray dryer, and under the action of the nozzle, the blend was atomized to form droplets and dried in the cavity. The supramolecular interaction between CD-PVP-PAM and Ad-PHEMA-PAM was strengthened during the drying process, and finally a dry complex of paclitaxel-embedded CD-PVP-PAM and Ad-PHEMA-PAM was formed, The composite swells to form supramolecular hydrogel microspheres under the rehydration action of deionized water. Figure 7 It is an electron micrograph of supramolecular h...

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Abstract

The invention belongs to the fields of supramolecular polymer polymer chemistry and drop formation control, and particularly relates to supramolecular hydrogel microsphere modified with cyclodextrin water-solubility polymer and adamantine water-solubility polymer and formed by assembling subjective and objective bodies in a liquid drop, and a preparation method and application thereof. The first purpose of the invention is to provide novel supramolecular hydrogel microsphere formed by assembling subjective and objective bodies and a preparation method thereof method, the second purpose of the invention is to adopt liquid drop as a template to realize supramolecular assembly and achieve uniform particle size and controllable dimension of the supramolecular hydrogel microsphere, and the third purpose of the invention is to provide application of the type of supramolecular hydrogel microsphere in adriacin doxorubicin and taxol water-solubility antitumor drug sustained release, so as to achieve the purpose that a drug can keep a high concentration level for a long time.

Description

technical field [0001] The invention belongs to the field of supramolecular polymer chemistry and droplet generation manipulation, in particular to the assembly of host and guest in droplets to form supramolecular hydrogel microspheres of water-soluble polymers modified with cyclodextrin and water-soluble polymers modified with adamantane method of preparation and use. Background technique [0002] Hydrogel microspheres, also known as microgels, refer to a polymer with internal crosslinking. Due to its specific spherical shape and stimuli-responsive properties, hydrogel microspheres have been coated in cells, Areas such as drug delivery, microreactors, and sensors show potential applications. [0003] The formation of hydrogel microspheres mainly depends on chemical cross-linking and physical cross-linking. Chemical cross-linking refers to connecting small molecules or macromolecules through the chemical force of covalent bonds to form a permanent and stable three-dimensio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075B01J13/02A61K47/40A61P35/00
Inventor 余子夷周进陈捷
Owner NANJING WISDOM BIOTECH
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