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Degradable and absorbable water soluble hemostatic material and preparation method thereof

A hemostatic material, water-soluble technology, applied in absorbent pads, medical science, bandages, etc., can solve the problems of inability to degrade, slow absorption and discharge, and achieve the effect of reducing chronic toxicity and good water solubility

Inactive Publication Date: 2010-11-24
HUIZHOU HUAYANG MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because carboxymethyl cellulose hemostatic materials are cellulose substances, and there are no enzymes to decompose cellulose in the human body, they cannot be degraded into carbon dioxide and water, and can only be converted into small molecules to be absorbed and excreted by the human body. In vitro, there are technical problems of slow absorption and excretion

Method used

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preparation example Construction

[0022] The present invention further provides a method for preparing a degradable and absorbable water-soluble hemostatic material, which mainly includes the following steps:

[0023] First, the regenerated cellulose is oxidized by an oxidation system to obtain oxidized regenerated cellulose with a carboxylic acid oxidation degree of not less than 5%. In this step, put viscose filament gauze or viscose staple fiber gauze with a degree of polymerization of 100-400 into the 2 or N 2 o 4 The oxidation is carried out in the nitrogen oxide oxidation system based on TEMPO, the nitrogen oxide oxidation system based on TEMPO or the homogeneous oxidation system of sodium nitrite or sodium nitrate phosphoric acid solution. The above-mentioned oxidation system is preferably a TEMPO-based nitroxide oxidation system, that is, an appropriate amount of TEMPO and sodium bromide is dissolved in water, and the regenerated cellulose fiber raw material is slowly added to the above-mentioned aqu...

Embodiment 1

[0030] Take 10g of viscose fiber gauze with a degree of polymerization of 100-400, and oxidize the viscose fiber gauze with a TEMPO-based nitrogen-oxygen oxidation system, that is, dissolve 1000mg of TEMPO and 2.4g of sodium bromide in 1500ml of water, and slowly add the gauze . Subsequently, 100 ml of sodium hypochlorite solution was added for reaction, and an appropriate amount of hydrochloric acid (HCL) was added to make the pH of the system reach about 10. Finally, the pH value of the reaction solution was maintained at 10.8 with 0.4 mol / L sodium hydroxide solution. After reacting for 80 minutes, the oxidized gauze was taken out, washed with 85% ethanol, and the washed gauze was dried.

[0031] The dried gauze is put into 20% sodium hydroxide solution for aging, and the halogenated acid etherification agent is put into the alkali solution for etherification reaction for 1 hour. Subsequently, the etherified gauze was taken out and put into 0.05% acetic acid solution for n...

Embodiment 2

[0033] Take 10g of viscose fiber gauze with a degree of polymerization of 100-400, and oxidize the viscose fiber gauze with a TEMPO-based nitrogen-oxygen oxidation system, that is, dissolve 2000mg of TEMPO and 4.8g of sodium bromide in 1500ml of water, and slowly add the gauze. Then, 200ml of sodium hypochlorite solution was added for reaction, and an appropriate amount of hydrochloric acid was added to make the pH of the system reach about 10. Finally, keep the reaction liquid value at 10.8 with 0.4mol / L sodium hydroxide solution. After reacting for 120 minutes, the oxidized gauze was taken out, washed with 85% ethanol, and the washed gauze was dried.

[0034] Put the dried gauze into 30% sodium hydroxide solution for aging, put the halogenated acid etherification agent into the alkali solution for etherification reaction, and the time is 1h. Subsequently, the etherified gauze is taken out, put into 0.05% acetic acid solution for neutralization, the neutralized gauze is take...

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Abstract

The invention provides a degradable and absorbable water soluble hemostatic material, which comprises an oxidized regenerated cellulose salt, wherein the carboxylic acid oxidizability of the oxidized regenerated cellulose salt is no less than 5 percent, the degree of etherification of the oxidized regenerated cellulose salt is 0.2 to 1.2, and the number-average molecular weight of the oxidized regenerated cellulose salt is 50,000 to 200,000. The hemostatic material of the invention can be used for stopping bleeding and preventing wound adhesion or used as wound dressing. The hemostatic material has the advantages of remarkable hemostatic effect, convenient absorption by human body and final discharge to the side of a human body and the like, and has high application values in clinic. The invention also provides a preparation method of the hemostatic material.

Description

【Technical field】 [0001] The invention relates to the technical field of hemostatic materials, in particular to a degradable and absorbable water-soluble hemostatic material and a preparation method thereof. 【Background technique】 [0002] Acute bleeding is the main cause of early death after trauma, so hemostasis is an important guarantee for maintaining life. Adult's blood accounts for about 8% of body weight, and blood has about 4000ml. During traumatic bleeding, when the blood loss reaches more than 20% of the total blood volume, obvious shock symptoms appear. When the blood loss reaches 40% of the total blood volume, it is life-threatening. Blood loss is a common problem in a series of operations such as tissue injury and surgery, so effective and rapid hemostasis is the key to the success of the operation. Bleeding brings great physical and psychological pain to the patient, and blood transfusion is required at the same time as a large amount of blood loss, which in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/62A61L15/64A61L15/60C08B15/04
Inventor 周晓成黄兴华
Owner HUIZHOU HUAYANG MEDICAL EQUIP
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