Preparation method of nanocellulose/oxidized regenerated cellulose composite hemostatic material

A technology of nanocellulose and regenerated cellulose, which is applied in the field of biomedical composite materials, can solve the problems of slow hemostatic rate and small improvement in hemostatic performance, and achieve the effects of reducing hemostatic time, improving hemostatic performance and increasing specific surface area

Inactive Publication Date: 2015-12-23
HARBIN INST OF TECH
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Problems solved by technology

[0009] The purpose of the present invention is to solve the problem of slow hemostatic rate and small improvement in hemostatic performance of existing modi...

Method used

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  • Preparation method of nanocellulose/oxidized regenerated cellulose composite hemostatic material
  • Preparation method of nanocellulose/oxidized regenerated cellulose composite hemostatic material

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specific Embodiment approach 1

[0033] Embodiment 1: The preparation method of the nanocellulose / oxidized regenerated cellulose composite hemostatic material provided in this embodiment is carried out according to the following steps:

[0034] First, the preparation of nanocellulose:

[0035] ① Take 1.0~5.0g of microcrystalline cellulose and 45mL of sulfuric acid solution with a certain mass fraction (the mass ratio between the two is about 1:15~45) and mix them in a clean beaker, turn on magnetic stirring, and at a temperature of 30~50℃ The reaction was carried out under the condition of water bath for 1~3h.

[0036] ② Pour the reaction solution into 400-500 ml of deionized water to complete the reaction, let it stand, and remove the supernatant. The suspension was washed 4-6 times by centrifugation in deionized water. A pH value of 5-7 was measured. After ultrasonic treatment for 15-30 min, the sol was put into a dialysis bag for purification treatment, and the outer dialysis fluid was deionized water. ...

specific Embodiment approach 2

[0061] Specific embodiment 2: The preparation method of the nanocellulose / oxidized regenerated cellulose composite hemostatic material provided by this embodiment is carried out according to the following steps:

[0062] First, the preparation of nanocellulose:

[0063] ① Mix 1.0g of microcrystalline cellulose and 45mL of sulfuric acid solution with a certain mass fraction (the ratio between the two is about 1:15) in a clean beaker, turn on magnetic stirring, and react in a water bath at 40°C for 2h. The effect of treating microcrystalline cellulose with different mass fractions of sulfuric acid is as follows figure 1 shown. Depend on figure 1 It can be seen that when the sulfuric acid concentration is 64 wt.%, a uniformly dispersed nanocellulose suspension is obtained.

[0064] ②Pour the reaction solution into 10 times the volume of deionized water to complete the reaction, let it stand, and remove the supernatant. The suspension was washed 5 times by centrifugation in de...

specific Embodiment approach 3

[0083] Embodiment 3: The difference between this embodiment and Embodiment 2 is that the amount of the microcrystalline cellulose is 3 g. Others are the same as the first embodiment.

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Abstract

The invention discloses a preparation method of a nanocellulose/oxidized regenerated cellulose composite hemostatic material. The method is carried out according to the steps of: 1. preparation of nanocellulose; 2. oxidation of nanocellulose; and 3. preparation of the nanocellulose/oxidized regenerated cellulose composite hemostatic material. According to the nanocellulose/oxidized regenerated cellulose composite hemostatic material provided by the invention, selective oxidation is carried out on the prepared nanocellulose through a TEMPO-NaClO-NaBr oxidation system, a sodium carboxylate structure is introduced to the C6 position of a nanocellulose molecule, and then compounding with oxidized regenerated cellulose is conducted, thereby increasing the specific surface area of oxidized regenerated cellulose, improving the hemostasis performance of the nanocellulose/oxidized regenerated cellulose composite hemostatic material, and overcoming the disadvantage of small improvement amplitude of hemostasis performance in ordinary oxidized regenerated cellulose and its composite hemostatic material. By using the nanocellulose/oxidized regenerated cellulose composite hemostatic material prepared by the method provided by the invention, the hemostasis time is reduced by 5-20%.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic material, belonging to the technical field of biomedical composite materials. Background technique [0002] A variety of sudden deaths will inevitably occur in daily life, and deaths caused by blood loss account for a considerable proportion. In emergency treatment and trauma hemostasis during surgery, there are also cases of medical malpractice or even death caused by massive bleeding. In a word, local effective and rapid hemostasis after injury is one of the key factors for the success or failure of life-saving. Therefore, effective hemostatic agents can avoid excessive blood loss, reduce morbidity and mortality to a great extent, and effectively control the amount of bleeding and reduce the bleeding time to become an important choice for reducing mortality. [0003] In the early days, due to limited technical conditions, people mainly used physical methods to stop bleeding, such as arti...

Claims

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Application Information

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IPC IPC(8): D06M15/05C08B15/02A61L15/28A61L15/44D06M101/06
CPCD01F2/00
Inventor 贺金梅刘长瑜黄玉东李纪伟程凤
Owner HARBIN INST OF TECH
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