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Preparation method of bleeding stopping and adherence preventing material

An anti-adhesion and base material technology, which is applied in the field of preparation of hemostatic and anti-adhesion materials, can solve the problems of strong acidity of degradation products, loss of function, poor adhesion, etc., achieve anti-adhesion tissue healing, promote tissue healing, and have no side effects

Inactive Publication Date: 2010-06-02
GUIZHOU JINJIU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has poor adhesion, is not easy to fix, and is difficult to control its degradation rate. It often loses its effect due to too fast degradation, and the degradation products cause local strong acidity, which inhibits the normal growth of tissue cells.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Take 10g of sodium carboxymethylcellulose powder with a viscosity of 100-500, take 70ml of 8% dextran solution and put it into a stirring vessel with a circulating device, start stirring at a constant speed, and put the weighed sodium carboxymethylcellulose 10g powder Slowly pour into a mixing vessel, stir for 30 minutes to dissolve, and take out the package.

Embodiment 2

[0023] Example 2. Take 10g of sodium carboxymethylcellulose fabric with a viscosity of 100-500, wash it three times with 50ml of 70% ethanol solution, take 2ml of 70% ethanol solution, add 3g of fibrinogen, 100 units of thrombin, and 400 units of coagulation factor Thirteen, shake well and pour it into a sprayer, spray it evenly on the sodium carboxymethyl cellulose fabric, dry the sprayed sodium carboxymethyl cellulose 10g fabric at 30°C for 2 hours, take out the package .

Embodiment 3

[0024] Example 3. Take 10g of sodium carboxymethylcellulose fabric with a viscosity of 100-500, wash it three times with 50ml of 70% ethanol solution, take 2ml of 70% ethanol solution, add 3g of fibrinogen, 100 units of thrombin, and 400 units of coagulation factor Thirteen, shake well and pour it into a sprayer, spray it evenly on the sodium carboxymethyl cellulose fabric, dry the sprayed 10g sodium carboxymethyl cellulose fabric at 30°C for 2 hours, then Dissolve it again to make a 30% solution, and take it out of the package.

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PUM

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Abstract

The invention discloses a preparation method of a bleeding stopping and adherence preventing material. In the method, soluble oxycellulose or oxidized regenerated cellulose is used as a base material, and dextran, fibrinogen and blood coagulation factors are added to the base material in a stirring or spraying mode to prepare a film or liquid. The prepared hemostasis and adherence preventing material has more effective bleeding stopping and adherence preventing effects and can quickly stop bleeding, prevent adherence and promote tissue healing, is completely degraded, can be absorbed and utilized by the human body, and has no side effect and safety use.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic and anti-adhesion material. Background technique [0002] At present, most of the anti-adhesion materials on the market are absorbable polymer synthetic materials, such as films made of polyglycolic acid, polylactic acid and their copolymers. However, it has poor adhesion, is not easy to fix, and is difficult to control its degradation rate. It often loses its effect due to too fast degradation, and the degradation products cause local strong acidity, which inhibits the normal growth of tissue cells. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a preparation method of a hemostatic and anti-adhesion material. The method uses soluble oxidized cellulose or oxidized regenerated cellulose as the substrate, and adds dextran, fibrinogen and blood coagulation factors into the substrate by stirring or spraying to form a film or liquid...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/14
Inventor 李洪波
Owner GUIZHOU JINJIU BIOTECH
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