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Preparation method of multi-wall carbon nano tube/chitosan/oxidized regenerated cellulose composite hemostatic material

A technology of multi-walled carbon nanotubes and regenerated cellulose, which is applied in the field of biomedical composite materials, can solve the problems of slow hemostatic rate and small improvement in hemostatic performance, achieve reduced hemostasis time, overcome small improvement, and realize factory production Effect

Active Publication Date: 2015-11-18
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to solve the problems of slow hemostatic rate and small improvement in hemostatic performance of the existing modified materials of oxidized regenerated cellulose, and provide a composite hemostatic compound of multi-walled carbon nanotubes / chitosan / oxidized regenerated cellulose Material preparation method

Method used

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  • Preparation method of multi-wall carbon nano tube/chitosan/oxidized regenerated cellulose composite hemostatic material
  • Preparation method of multi-wall carbon nano tube/chitosan/oxidized regenerated cellulose composite hemostatic material

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specific Embodiment approach 1

[0035]Embodiment 1: This embodiment provides a method for preparing a carbon nanotube / chitosan / oxidized regenerated cellulose composite hemostatic material, and its specific steps are as follows:

[0036] (1) Dissolve 2g of low-molecular-weight chitosan (CTS) with 50ml of acetic acid to form a chitosan / acetic acid solution, add mass fractions of 0.1%, 0.5% and 1% CNTs to the chitosan / acetic acid solution, and ultrasonically disperse After 60 min, a uniformly dispersed CNTs solution was obtained.

[0037] (2) Weigh 0.2g of oxidized regenerated cellulose, put it into the above CNTs solution and soak for 6h, 12h, 24h. Pre-freeze at ℃~-20℃ for 24 hours, put it into a freeze dryer after pre-freezing, and treat it for 24 hours at a temperature of -56℃~-20℃ and a vacuum of 10~40Pa to obtain carbon nanotubes / chitosan / oxidized Regenerated cellulose (CNTs / ORC) composite hemostatic material, its digital photos are shown in figure 1 As shown, the infrared spectrum is shown in figure 2...

specific Embodiment approach 2

[0038] Specific embodiment two: This embodiment provides a method for preparing an aminated carbon nanotube / chitosan / oxidized regenerated cellulose composite hemostatic material, and its specific steps are as follows:

[0039] (1) chitosan (CTS) with 50ml acetic acid dissolving 2g low molecular weight is made into chitosan / acetic acid solution, mass fraction 10%, 20%, 30%, 40%, 50% aminated carbon nanotube ( NH 2 -CNTs) were added into the chitosan / acetic acid solution, and ultrasonically dispersed for 60 min to obtain a uniformly dispersed CNTs solution.

[0040] (2) Weigh 0.2g of oxidized regenerated cellulose, put it into the above CNTs solution and soak for 6h, 12h, 24h. Pre-freeze at ℃~-20℃ for 24 hours, put it into a freeze dryer after pre-freezing, and treat it for 24 hours at a temperature of -56℃~-20℃ and a vacuum of 10~40Pa to obtain aminated carbon nanotubes / chitosan / oxidized regenerated cellulose (NH 2 -CNTs / ORC) composite hemostatic material, its digital photo...

specific Embodiment approach 3

[0041] Specific embodiment three: This embodiment provides a method for preparing a carboxylated carbon nanotube / chitosan / oxidized regenerated cellulose composite hemostatic material, and its specific steps are as follows:

[0042] (1) Chitosan (CTS) of 2g low molecular weight is made into chitosan / acetic acid solution with 50% acetic acid, massfraction 10%, 20%, 30%, 40%, 50% CNTs are added chitosan / In the acetic acid solution, ultrasonically disperse for 60 min to obtain a uniformly dispersed solution of carboxylated carbon nanotubes (COOH-CNTs), and then add 0.1 g of DCC to react for 12 h.

[0043] (2) Weigh 0.2g of oxidized regenerated cellulose, put it into the above CNTs solution and soak for 6h, 12h, 24h. Pre-freeze at ℃~-20℃ for 24 hours, put it into a freeze dryer after pre-freezing, and treat it for 24 hours at a temperature of -56℃~-20℃ and a vacuum of 10~40Pa to obtain carboxylated carbon nanotubes / chitosan / Oxidized regenerated cellulose (COOH-CNTs / ORC) composit...

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Abstract

The invention discloses a preparation method of a multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material. The preparation method of the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material comprises the following steps: (1) adding multi-wall carbon nano tubes into chitosan / diluted acid solution, and carrying out ultrasonic dispersion, so that uniformly dispersed multi-wall carbon nano tube solution is obtained; and (2) weighing oxidized regenerated cellulose, impregnating in the multi-wall carbon nano tube solution obtained in the step (1), washing with absolute ethyl alcohol after impregnation is finished, and finally prefreezing the washed oxidized regenerated cellulose and then treating in a freezer dryer, so that the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material is obtained. The prepared multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material has the advantages that carbon nano tubes are compounded with the oxidized regenerated cellulose, so that specific area of the oxidized regenerated cellulose is increased; meanwhile, chitosan is added, so that both hemostasis property and antibacterial property of the multi-wall carbon nano tube / chitosan / oxidized regenerated cellulose composite hemostatic material are improved, and the defect that the hemostasis property of common oxidized regenerated cellulose and a composite hemostatic material thereof is slightly improved is overcome.

Description

technical field [0001] The invention belongs to the technical field of biomedical composite materials, and relates to a preparation method of a hemostatic material. Background technique [0002] Various sudden deaths inevitably occur in daily life, and deaths caused by blood loss account for a considerable proportion. During emergency treatment and wound hemostasis during surgery, there are also cases of medical accidents or even death due to massive bleeding. In short, local and effective rapid hemostasis after the patient is injured is one of the key factors for the success of life saving. Whether the bleeding wound can be quickly stopped in a short period of time is very important. Therefore, effective hemostatic agents can avoid excessive blood loss, greatly reduce morbidity and mortality, and effectively control the amount of bleeding and reduce the bleeding time has become an important choice to reduce mortality. [0003] In the early days, due to limited technical c...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44
CPCA61L24/001A61L24/0078A61L2400/04C08L5/08C08L1/04
Inventor 贺金梅刘长瑜黄玉东李纪伟程凤陈以琳
Owner HARBIN INST OF TECH
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