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Preparation method of oxidized regenerated cellulose (ORC) absorbable hemostasis material

A technology for regenerated cellulose and hemostatic material, which is applied in the field of preparation of oxidative regenerated cellulose absorbable hemostatic material, can solve the problems of difficult control of the reaction process, pollution of the environment, unsuitable for industrialized production and the like, and achieves low cost, easy reaction process, The effect of solving environmental pollution

Inactive Publication Date: 2012-07-11
WEIGAO HLDG +1
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  • Abstract
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  • Application Information

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Problems solved by technology

[0006] The present invention aims to solve the problems that the existing preparation method of oxidized regenerated cellulose absorbable hemostatic material has high cost, pollutes the environment, the reaction process is difficult to control, and is not suitable for industrial production, and provides a preparation method of oxidized regenerated cellulose absorbable hemostatic material method

Method used

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  • Preparation method of oxidized regenerated cellulose (ORC) absorbable hemostasis material
  • Preparation method of oxidized regenerated cellulose (ORC) absorbable hemostasis material
  • Preparation method of oxidized regenerated cellulose (ORC) absorbable hemostasis material

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specific Embodiment approach 1

[0011] Specific Embodiment 1: The preparation method of the oxidized regenerated cellulose absorbable hemostatic material in this embodiment is carried out according to the following steps: 1. Nitrogen dioxide and cyclohexane are added to the circulating reactor to form an oxidizing liquid, and two in the oxidizing liquid The mass percent concentration of nitrogen oxide is 5% to 75%, and then regenerated cellulose is added to completely soak the regenerated cellulose in the oxidation solution, the reactor is sealed, and the reaction time is 1 to 72 hours at 5 to 45°C to obtain the oxidation product; 2. Rinse the oxidized product with cyclohexane for 2 to 5 times, then use an aqueous ethanol solution with a volume concentration of 20% to 95% to rinse the oxidized product 2 to 3 times, and then rinse the oxidized product with absolute ethanol for 3 to 5 times; 3. Then put the oxidized product rinsed with absolute ethanol at -80~-10℃ to freeze-dry for 24~72 hours to obtain the oxi...

specific Embodiment approach 2

[0014] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the concentration of nitrogen dioxide in the oxidation solution in step 1 is 20%-50% by mass. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0015] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the degree of polymerization of the regenerated cellulose in step 1 is 100-500. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method of an oxidized regenerated cellulose (ORC) absorbable hemostasis material, relates to a preparation method of the ORC absorbable hemostasis material, and aims to solve the problems of high preparation method, environment pollution, difficulty in reaction process and inconvenience in industrial production and the like in a conventional preparation method of the oxidized regenerated cellulose (ORC) absorbable hemostasis material. The preparation method provided by the invention comprises the steps that nitrogen dioxide and cyclohexane are added to a recycle reactor, regenerated cellulose is then added to the recycle reactor, the reactor is sealed, and an oxidation product is obtained after a reaction; the oxidation product is flushed by using cyclohexane, an ethanol aqueous solution and then absolute ethanol; the oxidation product is frozen and dried, and then the ORC absorbable hemostasis material is obtained. The preparation method of the ORC absorbable hemostasis material, which is provided by the invention, has the advantages that the oxidation efficiency of the ORC absorbable hemostasis material is equivalent to that achieved through using traditional solvents, the problems of environmental pollution and climatic influence are solved at the same time, the reaction process is easy to control; and the preparation method is suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of oxidized regenerated cellulose absorbable hemostatic material. Background technique [0002] Oxidized regenerated cellulose (ORC) is based on regenerated cellulose as raw material, and the regenerated cellulose is treated with a suitable oxidation system to oxidize the primary hydroxyl functional groups in the molecular structure of cellulose into carboxyl functional groups in a controlled manner, so that the content in the product reaches 16% to 24%, and finally the medical absorbable hemostatic material can be prepared through washing, drying, packaging, sterilization and other processes. [0003] For many years, oxidized regenerated cellulose has attracted the attention of researchers in many fields such as chemistry, biology, and medicine because of its excellent hemostatic properties and bioabsorbable properties. Nitrogen dioxide was the first oxidant that was found to selectively oxidize the prima...

Claims

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Application Information

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IPC IPC(8): C08B15/04A61L15/64A61L15/28
Inventor 黄玉东吴亚东贺金梅张华威高山
Owner WEIGAO HLDG
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