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Antibacterial osteogenesis-promoting absorbable bone wax and preparation method thereof

A technology for promoting bone and bone wax, applied in pharmaceutical formulation, application, medical science and other directions, can solve the problems of not being widely used or put on the market, unable to promote bone formation, difficult to effectively stop bleeding, etc., and achieve good blocking and hemostasis. Function, good bone healing effect, the effect of enhancing hemostatic ability

Inactive Publication Date: 2020-11-13
湖北联结生物材料有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] From 1980 to 2000, many bone wax substitutes were reported in the literature, such as fatty acid salts, fibrin / collagen paste, gelatin paste, glycolic acid or lactic acid / glycerol oligomers, partially deacetylated carapace However, these bone wax materials are difficult to combine the beneficial properties of traditional bone wax with the advantages of absorbable materials, and have not been widely used. use or place on the market
It was not until the 21st century that absorbable bone wax made of epoxy copolymer was developed. This bone wax has the advantages of simple use and effective hemostasis of traditional bone wax, and can degrade within 48 hours. However, due to its high water solubility , in the case of massive bleeding, it is difficult to effectively stop bleeding, and the function is single. It is only used as a hemostatic material, although it will not inhibit osteogenesis, but it cannot also play a role in promoting osteogenesis.

Method used

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  • Antibacterial osteogenesis-promoting absorbable bone wax and preparation method thereof
  • Antibacterial osteogenesis-promoting absorbable bone wax and preparation method thereof
  • Antibacterial osteogenesis-promoting absorbable bone wax and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An antibacterial and absorbable bone wax that promotes bone formation, the preparation method of which comprises the steps of:

[0037] 1) Grind and mix 95 parts by weight of calcium sulfate hemihydrate and 5 parts by weight of copper chloride evenly, stir and mix the uniformly mixed powder with water to form a mud (solid-liquid ratio is 1:0.4g:ml), and solidify at room temperature for 5 hours , dried at 80°C for 2 hours, and then ground into powder to obtain a calcium sulfate compound containing copper chloride;

[0038] 2) Weigh 60 parts of alkylene oxide copolymer with a molecular weight of 10,000-15,000, 15 parts of vitamin E acetate, 15 parts of hypromellose, and 10 parts of calcium sulfate compound, heat and melt at 80°C, and stir for 10 minutes , cooled to room temperature, and extruded until it is dough-like. The obtained bone wax does not stick to rubber gloves and can be shaped arbitrarily.

Embodiment 2

[0040] An antibacterial and absorbable bone wax that promotes bone formation, the preparation method of which comprises the steps of:

[0041] 1) Grind and mix 90 parts of calcium sulfate hemihydrate and 10 parts of copper chloride evenly, stir and mix the uniformly mixed powder with water to form a mud (solid-liquid ratio is 1:0.4g:ml), solidify at room temperature for 12 hours, and Drying at 80°C for 2 hours, and then grinding into powder to obtain calcium sulfate complex containing copper chloride;

[0042] 2) Weigh 80 parts of alkylene oxide copolymer with a molecular weight of 8000-10000, 20 parts of an alkylene oxide copolymer with a molecular weight of 2000-4000, 10 parts of chitosan, and 12 parts of calcium sulfate complex, and put them under the environment of 70 ℃ Heat and melt, stir for 15 minutes, cool to room temperature, and extrude until it becomes a paste-like shape. The obtained bone wax does not stick to rubber gloves and can be shaped arbitrarily.

Embodiment 3

[0044] An antibacterial and bone-inducing absorbable bone wax, the preparation method of which comprises the following steps: weighing 90 parts of an alkylene oxide copolymer with a molecular weight of 10,000 to 15,000, 25 parts of vitamin E acetate, 10 parts of hypromellose, two 12 parts of calcium sulfate water, heated and melted at 80°C, stirred for 20 minutes, cooled to room temperature, and extruded until it was in the shape of paste. The obtained bone wax did not stick to rubber gloves and could be shaped arbitrarily.

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Abstract

The invention discloses an antibacterial absorbable bone wax for promoting osteogenesis. The bone wax comprises the following components in parts by weight: 60-90 parts of an alkylene oxide copolymer,5-30 parts of a shaping agent, 2-30 parts of a thickening agent and 5-30 parts of a calcium sulfate-based repair component. The absorbable bone wax has good hemostatic performance and degradation performance, can be completely absorbed by a human body, promotes bone tissue regeneration, has a good continuous antibacterial effect and prevents wound infection. And the related preparation method issimple, is convenient to operate clinically, can meet the requirements of different patients, and is expected to be widely applied.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an antibacterial and bone-promoting absorbable bone wax and a preparation method thereof. Background technique [0002] Bone wax is a kind of hemostatic material used to control bleeding at the edge of bone during surgery. It is mechanically inserted into the bone cavity rich in bleeding capillaries to control bleeding. The main component of traditional bone wax is beeswax. After the wound is sealed, it cannot be degraded and remains in the wound area, which will seriously hinder bone healing. At present, there is no bone wax product that can be completely degraded in China, and the demand for degradable bone wax products is increasing day by day. [0003] From 1980 to 2000, many bone wax substitutes were reported in the literature, such as fatty acid salts, fibrin / collagen paste, gelatin paste, glycolic acid or lactic acid / glycerol oligomers, partially ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/0042A61L24/02A61L24/06A61L24/08A61L2300/106A61L2300/404A61L2300/406A61L2300/41A61L2300/412A61L2300/602A61L2400/04C08L71/02C08L5/08C08L5/04C08L1/284C08L1/286A61L24/0021A61L24/0089A61L2430/02
Inventor 蔡林张旗张铁闫飞飞邓洲铭魏任雄
Owner 湖北联结生物材料有限公司
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