Multi-medicament loaded calcium phosphate cement powder

A calcium phosphate bone cement and drug technology, applied in the field of biomedical materials and drugs, can solve the problems that calcium phosphate bone cement is difficult to meet clinical applications, and achieve the effects of promoting bone healing, promoting bone tissue growth, and preventing osteolysis

Inactive Publication Date: 2011-07-06
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing single-drug calcium phosphate bone cement is difficult to meet the needs of clinical application

Method used

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  • Multi-medicament loaded calcium phosphate cement powder
  • Multi-medicament loaded calcium phosphate cement powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:

[0024] Take early-release drug—10 grams of gentamicin sulfate, 11 grams of polylactic acid-glycolic acid copolymer microspheres loaded with 1 gram of long-term release drug—salvianolic acid B, 10 grams of hydroxyapatite, dihydrogen phosphate 45 grams of calcium, 37 grams of α-type tricalcium phosphate and 8 grams of calcium carbonate are directly blended and mixed uniformly to obtain the calcium phosphate bone cement powder loaded with multiple drugs of this example. The dry matter weight ratio is: calcium phosphate 100 parts of bone cement powder (10 parts of hydroxyapatite + 45 parts of calcium dihydrogen phosphate + 37 parts of α-type tricalcium phosphate + 8 parts of calcium carbonate), the polymer used for the polymer microspheres loaded with long-term drug release—— 10 parts of polylactic acid-glycolic acid copolymer, 1 part of long-term relea...

Embodiment 2

[0027] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:

[0028] Take the pre-release drug—5.5 grams of acetaminophen with analgesic effect, 1.5 grams of gelatin microspheres loaded with 1 gram of long-term release drug—salvianolic acid B, 7 grams of hydroxyapatite, and 24 grams of calcium dihydrogen phosphate. gram, 55 grams of α-type tricalcium phosphate, and 14 grams of calcium carbonate were directly blended, and mixed uniformly, the calcium phosphate bone cement powder loaded with multiple drugs of this example was obtained. The mass ratio of dry matter is: 100 parts of calcium phosphate bone cement powder (7 parts of hydroxyapatite powder + 24 parts of calcium dihydrogen phosphate + 55 parts of α-type tricalcium phosphate + 14 parts of calcium carbonate), the early release drug—— 5.5 parts of acetaminophen, 1 part of salvianolic acid B, a long-term release drug, and 0.5 part of gelatin, a polymer used ...

Embodiment 3

[0030] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:

[0031] Take the pre-release drug - 5 grams of penicillin, 5 grams of brown mycin and 5 grams of fluchloramphenicol, loaded with 20 grams of long-term release drug - 60 grams of polyhydroxybutyrate microspheres of the Chinese medicine ligustrazine extract and calcium carbonate powder 40 grams, 10 grams of hydroxyapatite, and 50 grams of beta-type tricalcium phosphate powder were mixed uniformly together to obtain the multi-drug-loaded calcium phosphate bone cement powder of this example.

[0032] The dry matter weight ratio of the product obtained in this example is: 100 parts of calcium phosphate bone cement powder (40 parts of calcium carbonate+10 parts of hydroxyapatite powder+50 parts of β-type tricalcium phosphate powder), loaded with long-term release drug The macromolecules used in the polymer microspheres—40 parts of polyhydroxybutyrate, long...

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Abstract

The invention discloses multi-medicament loaded calcium phosphate cement powder. The multi-medicament loaded calcium phosphate cement powder is prepared by directly mixing more than one prophase release medicament, polymer microspheres loaded with a long-term release medicament and calcium phosphate cement powder, or performing precipitation blending on more than one prophase release medicament and an ingredient in the calcium phosphate cement powder and uniformly mixing the obtained product with other ingredients of the calcium phosphate cement powder and the polymer microspheres loaded with the long-term release medicament. The powder is suitable for filling and repairing bone defects with different volumes and different shapes; moreover, the loaded prophase release medicaments and the loaded long-term release medicament can be released for co-administration in different time sequences at local positions of the bone defects; and the powder, through the synergism, enhances therapeutic effect, promotes bone healing, improves the success rate of clinical filling and repair of the bone defects, and can reduce the side effect of the medicaments on organisms and meet the clinical demand on bone filling and repair materials at the same time.

Description

technical field [0001] The invention relates to the fields of biomedical materials and medicines, in particular to calcium phosphate bone cement powder loaded with various medicines. Background technique [0002] Calcium Phosphate Cement (CPC) is a self-curing artificial bone replacement material developed by Brown and Chow in the mid-1980s (Brown WE, Chow LC. A new calcium phosphate setting cement. Journal Dental Research, 1983; 62 :672). The composition of calcium phosphate bone cement includes solid phase and liquid phase, the solid phase is mainly composed of one or several calcium phosphate salts or a mixture of other calcium salts, and the liquid phase can be distilled water, dilute acid, serum, blood, phosphate buffer (PBS) etc. (Bohner M. Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements. Injury. 2000; 31: 37-47.). After more than 20 years of development, many calcium phosphate bone cements with different formulations have been formed....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/12A61K47/02A61K47/34A61K47/36A61K47/42A61P19/08
Inventor 屈树新林孙忠李茂红翁杰
Owner SOUTHWEST JIAOTONG UNIV
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