Multi-medicament loaded calcium phosphate cement powder
A calcium phosphate bone cement and drug technology, applied in the field of biomedical materials and drugs, can solve the problems that calcium phosphate bone cement is difficult to meet clinical applications, and achieve the effects of promoting bone healing, promoting bone tissue growth, and preventing osteolysis
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Embodiment 1
[0023] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:
[0024] Take early-release drug—10 grams of gentamicin sulfate, 11 grams of polylactic acid-glycolic acid copolymer microspheres loaded with 1 gram of long-term release drug—salvianolic acid B, 10 grams of hydroxyapatite, dihydrogen phosphate 45 grams of calcium, 37 grams of α-type tricalcium phosphate and 8 grams of calcium carbonate are directly blended and mixed uniformly to obtain the calcium phosphate bone cement powder loaded with multiple drugs of this example. The dry matter weight ratio is: calcium phosphate 100 parts of bone cement powder (10 parts of hydroxyapatite + 45 parts of calcium dihydrogen phosphate + 37 parts of α-type tricalcium phosphate + 8 parts of calcium carbonate), the polymer used for the polymer microspheres loaded with long-term drug release—— 10 parts of polylactic acid-glycolic acid copolymer, 1 part of long-term relea...
Embodiment 2
[0027] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:
[0028] Take the pre-release drug—5.5 grams of acetaminophen with analgesic effect, 1.5 grams of gelatin microspheres loaded with 1 gram of long-term release drug—salvianolic acid B, 7 grams of hydroxyapatite, and 24 grams of calcium dihydrogen phosphate. gram, 55 grams of α-type tricalcium phosphate, and 14 grams of calcium carbonate were directly blended, and mixed uniformly, the calcium phosphate bone cement powder loaded with multiple drugs of this example was obtained. The mass ratio of dry matter is: 100 parts of calcium phosphate bone cement powder (7 parts of hydroxyapatite powder + 24 parts of calcium dihydrogen phosphate + 55 parts of α-type tricalcium phosphate + 14 parts of calcium carbonate), the early release drug—— 5.5 parts of acetaminophen, 1 part of salvianolic acid B, a long-term release drug, and 0.5 part of gelatin, a polymer used ...
Embodiment 3
[0030] The calcium phosphate bone cement powder loaded with multiple drugs of this example is prepared by the following method:
[0031] Take the pre-release drug - 5 grams of penicillin, 5 grams of brown mycin and 5 grams of fluchloramphenicol, loaded with 20 grams of long-term release drug - 60 grams of polyhydroxybutyrate microspheres of the Chinese medicine ligustrazine extract and calcium carbonate powder 40 grams, 10 grams of hydroxyapatite, and 50 grams of beta-type tricalcium phosphate powder were mixed uniformly together to obtain the multi-drug-loaded calcium phosphate bone cement powder of this example.
[0032] The dry matter weight ratio of the product obtained in this example is: 100 parts of calcium phosphate bone cement powder (40 parts of calcium carbonate+10 parts of hydroxyapatite powder+50 parts of β-type tricalcium phosphate powder), loaded with long-term release drug The macromolecules used in the polymer microspheres—40 parts of polyhydroxybutyrate, long...
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