Hard tissue repairing material and its prepn

A technology for repairing materials and hard tissues, applied in medical science, prosthesis, surgery, etc., can solve the problems of unfavorable bone healing, unfavorable bone synthesis, low strength, etc., to improve biodegradable absorption function, accelerate bone healing, and low cost Effect

Inactive Publication Date: 2003-03-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no detailed description in the literature that this material has a significant effect of inducing bone growth, which is not conducive to bone synthesis and delays bone healing
[0009] Demineralized bone can be used for bone repair, granular and membranous materials are commonly used, they have good biocompatibility, but they have low strength and are easily absorbed
[0010] Some people mix polylactic acid with demineralized bone to improve the mechanical properties of bone repair materials, etc., but the inflammatory reaction produced by polylactic acid is not good for bone healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Preparation of hard tissue repair materials: Absorbable synthetic polymer materials can be used in poly-L-lactic acid, poly-(D, L)-lactic acid, polyglycolic acid, polycaprolactone, polybutyrolactone, polyvalerolactone One or a copolymer of at least two of the following monomers: L-lactic acid, (D, L)-lactic acid, glycolic acid, caprolactone, butyrolactone, valerolactone, or their blends. For example, 0.8 g of poly-L-lactic acid is dissolved in dioxane, 0.2 g of unsintered hydroxyapatite with a particle size of about 1 micron is dispersed in dioxane, the two are mixed, and 0.5 g of demineralized bone The particles are dispersed in the system, and an appropriate amount of gentamicin is added, and the above mixture is injected into the cavity—a cylindrical mold with a diameter of 15 mm and a height of 20 mm, freeze-dried at -70°C, sterilized with ethylene oxide, A porous hard tissue repair material is obtained.

Embodiment 2

[0038] Dissolve 0.8 gram of poly-L-lactic acid with a weight average molecular weight of 150,000 in dioxane, disperse 0.2 gram of unsintered hydroxyapatite with a particle size of about 1 micron in dioxane, mix the two, and Disperse 0.1 gram of demineralized bone particles in the system, add 0.5 mg of human gene recombinant bone morphoprotein (BMP), and add an appropriate amount of gentamicin, mix well, and inject the mixture into the cavity—the diameter is 15 mm and the height is In a 20mm cylindrical mold, freeze-dry at -70°C and sterilize with ethylene oxide to obtain a porous hard tissue repair material.

Embodiment 3

[0040] Preparation of hard tissue repair materials: unsintered calcium phosphate salt can use low-temperature synthesized hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), calcium pyrophosphate (Ca 2 P 2 o 7 ), calcium hydrogen phosphate (CaHPO 4 ), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O) one or a mixture of two or more calcium phosphate salts. For example, using unsintered tricalcium phosphate (Ca 3 (PO 4 ) 2 ). Dissolve 0.8 gram of poly L-lactic acid with a weight average molecular weight of 150,000 in dioxane, disperse 0.1 gram of unsintered tricalcium phosphate with a particle size of about 1 micron in dioxane, mix the two, and Add an appropriate amount of gentamicin, disperse 0.3 g of demineralized bone particles in dioxane, and mix with the former, inject the above mixture into the cavity - a cylindrical mold with a diameter of 15 mm and a height of 20 mm , Freeze-dried at -70°C and sterilized with ethylene o...

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Abstract

The present invention relates to surgical material. The material includes biological absorbable polymer 10-85 wt%, un-sintered calcium phosphate salt 5-80 wt%, and demineralized bone 1-70 wt%. The biologically absorbable polymer includes polyester, chitosan, hondroitin sulfate, collagen, alginatel, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbable polymer, un-sintered calcium phosphate salt and demineralized bone dispersed in solvent and freeze drying to obtain the hard tissue repairing material. The composition has the function of promoting bone healing and excellent biocompatibility.

Description

1. Technical field: [0001] The invention relates to a hard tissue repair material and a preparation method thereof, belonging to the technical field of preparation of materials for medical surgery. 2. Background technology: [0002] Hard tissues such as human bones and teeth are damaged due to disease or trauma, and artificial materials are required for repair or correction. Such repair materials include metals, inorganic materials, polymer materials, etc. [0003] Bone repair materials made of stainless steel or titanium alloy have high strength, low cost, and high frequency of use, but stress shielding may occur, which may lead to bone resorption, delay bone healing, and poor tissue compatibility. lead to inflammatory reactions, etc. [0004] Hydroxyapatite and tricalcium phosphate are commonly used bioceramics. Calcium phosphate bone cement is also commonly used in hard tissue repair. It has good biocompatibility. Hydroxyapatite can also induce osteogenesis, but its tex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61L31/12
Inventor 李新松浦跃朴叶浪
Owner SOUTHEAST UNIV
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