20 results about "Calcium pyrophosphate" patented technology

The invention discloses an application of monocalcium aluminate in a premixed dental filling material, the premixed dental filling material and a preparation method of the premixed dental filling material, the premixed dental filling material takes monocalcium aluminate as a main hydraulic material, calcium oxide is supplemented as a curing accelerator and an expanding agent, and the premixed dental filling material can also comprise calcium pyrophosphate, calcium carbonate, calcium carbonate and calcium carbonate. The biological hydrogel paste with excellent injectable performance is prepared. The material keeps fluid under a sealed condition, and is hydrated, solidified and hardened after being placed in a physiological environment and contacted with physiological body fluid. According to the present invention, by using the excellent biocompatibility and the biological activity of the monocalcium aluminate, the premixed aluminate hydrogel dental filling material is prepared from the monocalcium aluminate, and can be used for medical applications and dental applications, including the fields of pulp capping, root canal therapy, hard tissue repair and the like.

The invention relates to a sliding material based on PTFE polymer with a filler to improve the friction properties, wherein the filler comprises at least one phosphate, in particular calcium phosphate, calcium pyrophosphate, magnesium phosphate, magnesium pyrophosphate, lithium phosphate, hydroxyapatite or combinations thereof, and at least one metal sulfide, wherein the proportion of metal sulfide is > 2%. The invention also relates to the use of the sliding material.

The invention relates to a wear-resistant thermoplastic elastomer and a preparation method thereof. The wear-resistant thermoplastic elastomer is prepared from the following raw materials in parts by mass: 80 to 120 parts of thermoplastic polyurethane, 10 to 30 parts of fluorine-treated mesoporous silicon dioxide, 1 to 3 parts of graphene oxide, 1 to 2 parts of silane coupling agent, 5 to 15 parts of SEBS copolymer, 5 to 15 parts of flexibilizer, 1 to 5 parts of compatilizer, 5 to 15 parts of ammonium polyphosphate, 1 to 5 parts of calcium pyrophosphate whisker, 1 to 2 parts of melamine cyanurate and 1 to 3 parts of calcium stearate. 1-2 parts of an ultraviolet light absorber, 1-2 parts of a light stabilizer, 1-2 parts of an antioxidant and 1-2 parts of a heat-resistant agent. The mechanical property of the thermoplastic elastomer material can be remarkably improved, the thermoplastic elastomer material has good flexibility and elastic property, the flame retardant property of the material is remarkably improved, and the toughness and wear resistance of the material are further enhanced.

Disclosed herein are compounds having the structure of Formula (I): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein A, Q1, R2, R3, Q4, R5, R6, R7, R and n are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of ENPP1 and are useful in the treatment of diseases, disorders and conditions related to ENPP1 activity. In particular, the compounds are useful for treating a disease or condition selected from an infection (including but not limited to bacterial infections and viral infections), proliferative disorders (such as cancer or a tumor), cardiovascular disease (including cardiac injury), diabetes or insulin resistance, chondrocalcinosis, calcium pyrophosphate deposition disorder (pseudogout), or hypophosphatasia.

This invention relates to a desensitizing drug for tooth enamel repair and its preparation method, belonging to the field of biomedical technology. The drug comprises a specific ratio of paeonol-dopamine modified chitosan quaternary ammonium salt, enzyme-responsive precursor mineral, polyethylene glycol didopamine modified hydroxyapatite, strontium nitrate, hyaluronic acid-maleimide, L-cysteine, and carbomer. The paeonol-dopamine modified chitosan quaternary ammonium salt is obtained by modifying chitosan quaternary ammonium salt with paeonol and dopamine hydrochloride under tyrosinase catalysis. The enzyme-responsive precursor mineral is obtained by coating nano-calcium pyrophosphate with ε-polylysine. The polyethylene glycol didopamine modified hydroxyapatite is obtained by surface adhesion modification of hydroxyapatite with polyethylene glycol didopamine. This invention yields a restorative desensitizing gel with strong adhesion and enzyme responsiveness. This gel can form a long-lasting protective layer on the tooth surface, simultaneously achieving the triple effects of physical sealing, nerve inhibition, and active mineralization.

The invention relates to calcium pyrophosphate biological ceramic with a bone-imitating oriented structure as well as a preparation method and application of the calcium pyrophosphate biological ceramic. The bone-imitating oriented structure calcium pyrophosphate biological ceramic has a layered structure formed by alternately arranging calcium pyrophosphate crystal phase layers formed by dehydration condensation of brushite and amorphous carbon layers formed by carbonization of carboxymethyl chitosan. The bone-imitating oriented structure calcium pyrophosphate biological ceramic has significantly improved strength and toughness, also has good cytocompatibility, and is a potential load-bearing bone repair material. The bionic design based on the bone tissue orientation structure provides a new strategy for preparing high-strength and high-toughness bioactive materials.

The invention discloses a production method and application of toothpaste-grade calcium pyrophosphate, the production method comprises the following steps: mixing calcium hydrophosphate with a magnesium source, heating to 750-830 DEG C at a rate of 4-6 DEG C / min, calcining for 2-4 hours, then carrying out three-gradient cooling on the calcined product, and finally crushing to obtain the toothpaste-grade calcium pyrophosphate, wherein the three-gradient cooling comprises the steps of heating and slowly cooling to 500 DEG C at the speed of 10-15 DEG C / min, then naturally cooling to 100-150 DEG C, and finally cooling to below 50 DEG C at the speed of 3-5 DEG C / min. The prepared toothpaste-grade calcium pyrophosphate is high in beta-phase conversion rate, small in tooth abrasion value, uniform in particle size distribution, excellent in performance when applied to toothpaste grinding materials and wide in application prospect.

The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating calcium pyrophosphate deposition disease and hypophosphatasia, comprising a benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase.

The invention discloses a shell-derived biphase calcium phosphate composite bone repair material as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the preparation method, the shell-source calcium source and the calcium pyrophosphate are mixed, the biphase calcium phosphate (BCP) containing HAP and beta-TCP in different proportions is prepared through wet ball milling and solid-phase reaction, the reaction conditions are controlled in a simple mode, and the proportion of HAP to beta-TCP in the BCP is controllable. The biphase calcium phosphate prepared by the method is further compounded with sodium alginate, and the biphase calcium phosphate-sodium alginate composite scaffold is prepared by freeze drying and Cacrosslinking. The composite scaffold has a suitable porous structure, can exert in-vitro osteogenic induction activity and an in-vivo bone defect repair function, can significantly induce MC3T3-E1 cell alkaline phosphatase activity and induce calcium deposition, has osteogenic induction activity, can induce bone defect repair at an in-vivo rat skull defect part, and has a good application prospect. Excellent bone tissue engineering application prospects are shown.

The application discloses anhydrous toothpaste and a preparation method thereof. The anhydrous toothpaste comprises a humectant, a thickening agent, an abrasive and an efficacy component; the humectant is composed of at least one of PEG 400 and propylene glycol and glycerol, and the amount of the glycerol is not more than 40% of the total weight of the anhydrous toothpaste; the thickening agent comprises microcrystalline cellulose; the abrasive is composed of at least one of calcium hydrogen phosphate dihydrate and calcium pyrophosphate and calcium hydrogen phosphate and hydrated silica, and the calcium hydrogen phosphate is the main abrasive; and the efficacy component comprises sodium monofluorophosphate and sodium phytate. The anhydrous toothpaste can improve the burning and irritating taste of the anhydrous toothpaste; the calcium hydrogen phosphate is used as the main abrasive, the sodium monofluorophosphate is used as a repairing and remineralizing component, the two components are compatible, the soluble fluorine concentration can be improved, and the tooth remineralization and acid erosion resistance can be ensured; and the microcrystalline cellulose thickening does not need to be neutralized and is resistant to high-speed shearing, so that the system damage caused by incompatible raw materials during the shelf life is avoided, and the stability is improved.

The invention discloses a phosphorus-doped biochar material, a preparation method and application of the phosphorus-doped biochar material in water treatment, and relates to the technical field of organic pollutant catalytic degradation materials, the phosphorus-doped biochar material is obtained by phytic acid treatment of an ardealite modified phase and original carbon after biomass pyrolysis; the ardealite modified phase comprises calcium pyrophosphate and ardealite. The preparation method of the phosphorus-doped biochar material comprises the following steps: S1, mixing an ardealite modified phase and biomass, performing pyrolysis, adding an iron solution, and performing mixing to obtain original carbon; s2, treating the original carbon with phytic acid to obtain the phosphorus-doped biochar material. According to the application of the phosphorus-doped biochar material in water treatment, the phosphorus-doped biochar material is used as a catalytic material for degrading organic pollutants by persulfate, and the phosphorus-doped biochar material is high in organic pollutant catalytic degradation efficiency, wide in pH application range and good in stability.

The invention belongs to the technical field of agricultural environment-friendly materials, and relates to a PLA / PBAT biodegradable composite mulching film for quinoa, which is prepared from the following raw materials in parts by mass: 45 to 50 parts of PLA, 50 to 55 parts of PBAT, 6 to 8 parts of biodegradable regulator, 20 to 30 parts of modified crop straw powder, 1 to 3 parts of biodegradable silver master batch, 2 to 4 parts of nano zinc oxide, 0.5 to 1 part of chain extender containing epoxy group, 3 to 5 parts of compatibilizer containing epoxy group and 0.2 to 0.5 part of lubricant. The biodegradation regulator has a core-shell structure, the core is C12-C18 choline carboxylate, and the shell is calcium pyrophosphate; the modified crop straw powder is obtained by sequentially impregnating superfine crop straw powder with an inorganic alkali solution, impregnating with a quaternary ammonium salt type surfactant aqueous solution and modifying with an epoxy silane coupling agent. The mulching film disclosed by the invention can basically keep a complete structure in the growth period of the quinoa in the high-altitude saline-alkali area, has a cooling function in a high-temperature period in summer, and can be quickly degraded within 40-60 days after the quinoa is harvested.

The application belongs to the technical field of biodegradable polymer materials, and relates to a controllable biodegradable high-strength polylactic acid composite mulching film and a preparation method thereof. The mulching film is a three-layer composite structure, and the layers from top to bottom are a surface layer, a middle layer and an inner layer. The raw materials of the surface layer include PLA, PPC, PCL and a core-shell structure degradation regulator. The core-shell structure degradation regulator takes an imidazole phosphate as a core and takes calcium pyrophosphate as a shell. The raw materials of the middle layer include PLA, PBAT, an epoxy-containing compatibilizer and an epoxy-containing chain extender. The raw materials of the inner layer include PLA, starch and humic acid. The core-shell structure degradation regulator has a slow-release catalytic function and has a regulating effect on the degradation of the mulching film. The surface layer of the composite mulching film provides a degradation regulating function. The middle layer provides mechanical support. The inner layer activates soil bacteria and promotes crop growth. The three layers realize the contradictory requirements of high initial strength, long functional period and rapid degradation in the later period through synergistic action.

The invention discloses a flotation inhibitor and a lime inhibition-free flotation method for high-sulfur lead zinc ore. The flotation inhibitor is zinc calcium pyrophosphate. The flotation method comprises the following steps: (1) crushing, screening and grinding the high-sulfur lead-zinc ore to obtain ore powder; (2) adding the ore powder and water into a flotation tank, stirring, and adding an inhibitor, a collecting agent and a foaming agent for flotation; the inhibitor is zinc calcium pyrophosphate. The flotation inhibitor has the effect of selectively inhibiting sphalerite and pyrite in the high-sulfur lead-zinc ore, the grade and the recovery rate of lead concentrate are improved, lime does not need to be added in the flotation process to inhibit the high-sulfur lead-zinc ore, and the flotation inhibitor has both environmental protection and economic benefits.

The invention belongs to the technical field of biodegradable high polymer materials, and relates to a controllable biodegradable high-strength polylactic acid composite mulching film and a preparation method thereof.The mulching film is of a three-layer composite structure and sequentially comprises a surface layer, a middle layer and an inner layer from top to bottom; the surface layer comprises the following raw materials: PLA, PPC, PCL and a core-shell structure degradation regulator, and the core-shell structure degradation regulator takes imidazole phosphate as a core and calcium pyrophosphate as a shell; the middle layer is prepared from the following raw materials: PLA, PBAT, a compatibilizer containing an epoxy group and a chain extender containing an epoxy group; the inner layer is prepared from the following raw materials: PLA, starch and humic acid. The degradation regulator with the core-shell structure has a slow-release catalysis function and has a regulation effect on degradation of a mulching film. The surface layer of the composite mulching film provides a degradation regulation function; the middle layer provides mechanical support; the inner layer activates soil flora and promotes crop growth; through the synergistic effect of the three layers, the contradictory requirements of high initial strength, long functional period and rapid degradation in the later period of the mulching film are met.

A purpose of the present invention is to provide a negative thermal expansion material including a zinc-phosphorus composite oxide having excellent negative thermal expansion properties.　The negative thermal expansion material includes a composite of a zinc-phosphorus composite oxide and a calcium pyrophosphate salt, and is characterized in that the zinc-phosphorus composite oxide includes a zinc-phosphorus composite oxide represented by a general formula (1) (ZnxMyPz1Ot1), and the calcium pyrophosphate salt includes a calcium pyrophosphate salt represented by a general formula (2) (Caw1Aw2Pz2Ot2).

A medical dissolvent is provided for use as a medical treatment for calcium pyrophosphate deposition disease (pseudo-gout). The medical dissolvent is capable as functioning as a solubilizing agent for crystalline structures containing calcium pyrophosphate due to its unique chemical complex structure, which is formed by a chelating agent bound to metal cations. The chemical structure is both deliverable and removable through a solution or a medical insert.

A dentifrice composition including from about 0.0025% to about 5%, by weight of the dentifrice composition, of a tin ion source, where the tin ion source does not comprise stannous fluoride, calcium pyrophosphate, and up to about 45%, by weight of the dentifrice composition, of water. The dentifrice composition has a pH of greater than 7.

The invention relates to a desensitization medicine for repairing enamel and a preparation method of the desensitization medicine, and belongs to the technical field of biological medicines. The medicine is prepared from paeonol-dopamine modified chitosan quaternary ammonium salt, enzyme response precursor minerals, polyethylene glycol didopamine modified hydroxyapatite, strontium nitrate, hyaluronic acid-maleimide, L-cysteine, carbomer and the like according to a specific proportion. The paeonol-dopamine modified chitosan quaternary ammonium salt is obtained by modifying chitosan quaternary ammonium salt with paeonol and dopamine hydrochloride under the catalytic condition of tyrosinase. The enzyme response precursor mineral is obtained by coating nano calcium pyrophosphate with epsilon-polylysine. The polyethylene glycol didopamine modified hydroxyapatite is obtained by carrying out surface adhesion modification on hydroxyapatite through polyethylene glycol didopamine. The repairing desensitization gel with strong adhesion and enzyme responsiveness is obtained, and the gel can form a long-acting protective layer on a dental surface and simultaneously realize triple effects of physical sealing, nerve inhibition and active mineralization.