A nano-class fermented active organic fertilizer is prepared from ammonium humate organonitrogen, ammonium polyphosphate, ammonium phosphate, calcium potassium pyrophosphate, organopotassium, additive and water through screening raw materials, grinding, biochemical reacting, adding additive, granulating, compounding, drying, cooling and coating. Its advantages are no poison and environmental pollution, and multiple functions including improving soil and crops, regulating growth of plant, increasing yield of crops, resisting diseases and bacteria, etc.