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Preparation process of degradable foam-like strontium-doped calcium phosphate ceramic bone holder material

A technology of strontium calcium phosphate and preparation process is applied in the field of preparation of degradable foamed strontium-doped calcium phosphate ceramic scaffold materials, which can solve the problem that it cannot be used as a bone scaffold material, the degradability is not improved, and the specific strength of porous materials is not mentioned. problem, achieve good biocompatibility and degradability, and improve the effect of material strength

Inactive Publication Date: 2006-04-26
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this improved method has obtained a porous structure with a porosity as high as 70% and interpenetrating pores to a certain extent, its chemical composition is still hydroxyapatite, and its degradability has not been improved, and the specific strength of the porous material has not been mentioned. , not yet a potential bone scaffold material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Ca 4 (PO 4 ) 2 O. SrHPO 4 、CaHPO 4The powders are mixed according to the molar ratio of 2:1.5:0.5 to make strontium-doped calcium phosphate bone cement solid phase powder. Use a 50ml small beaker to weigh 1.2g of the powder, then mix it with 0.6g of dilute phosphoric acid solidified solution with a concentration of 1.0mol / l, and mix with a medicine spoon for 30s to form a uniform cement slurry. Set the volume to 1cm 3 1. Cubic polyurethane foam with a pore size of 400 μm is immersed in the above cement slurry, and the foam is repeatedly pressed and loosened with a medicine spoon, so that the cement slurry is evenly coated on the foam network as much as possible, and then squeeze out the excess slurry occupying the foam pores and liquid. The foam sample coated with cement slurry was placed in an air environment at 37°C and 100% humidity for 48 hours to cure, and a foam / cement composite with certain strength was obtained. Put the cured composite into an oven at 110...

Embodiment 2

[0018] The particle sizes were 10.0μm, 1.2μm, 1.0μm Ca 4 (PO 4 ) 2 O. SrHPO 4 , CaHPO 4 The powders were mixed according to the molar ratio of 2:1.0:1.0 to make strontium-doped calcium phosphate bone cement solid phase powder. Use a 50ml small beaker to weigh 1.2g of the powder, then mix it with 0.9g of dilute phosphoric acid solidified solution with a concentration of 0.50mol / l, and mix with a spatula for 30s to form a uniform cement slurry. Set the volume to 1cm 3 1. Cubic polyurethane foam with a pore size of 400 μm is immersed in the above cement slurry, and the foam is repeatedly pressed and loosened with a medicine spoon, so that the cement slurry is evenly coated on the foam network as much as possible, and then squeeze out the excess slurry occupying the foam pores and liquid. The foam sample coated with cement slurry was placed in an air environment at 37°C and 100% humidity for 48 hours to cure, and a foam / cement composite with certain strength was obtained. P...

Embodiment 3

[0020] The particle sizes were 10.0μm, 1.2μm, 1.0μm Ca 4 (PO 4 ) 2 O. SrHPO 4 , CaHPO 4 The powders were mixed according to the molar ratio of 2:1.0:1.0 to make strontium-doped calcium phosphate bone cement solid phase powder. Use a 50ml small beaker to weigh 1.2g of the powder, then mix it with 0.6g of dilute phosphoric acid solidified solution with a concentration of 0.10mol / l, and mix with a medicine spoon for 30s to form a uniform cement slurry. Set the volume to 1cm 3 1. Cubic polyurethane foam with a pore size of 400 μm is immersed in the above cement slurry, and the foam is repeatedly pressed and loosened with a medicine spoon, so that the cement slurry is evenly coated on the foam network as much as possible, and then squeeze out the excess slurry occupying the foam pores and liquid. The foam sample coated with cement slurry was placed in an air environment at 37°C and 100% humidity for 48 hours to cure, and a foam / cement composite with certain strength was obtai...

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PUM

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Abstract

The present invention discloses the preparation process of bone tissue engineering rack material of degradable foamed Sr-doped calcium phosphate ceramic. It is prepared through bone cement copying foam structure process, and the Sr-doped apatite bone cement slurry as material includes solid phase particles of Ca4(PO4)2, CaPO4 and SrPO4 in certain molar ratio and liquid phase of 0.5-1.0 mol / L H3PO4 aqua in the solid / liquid ratio of 1.5-3.0. Polyurethane foam template is adopted. The final product is mixture of Sr-doped apatite and tricalcium strontium phosphate or the mixture of tricalcium strontium phosphate and calcium strontium pyrophosphate, and its component phase contents may be controlled through regulating the molar ratio of materials, solid / liquid ratio and phosphoric acid concentration so as to control the material degrading rate.

Description

technical field [0001] The invention relates to a preparation technology of a degradable foam-like strontium-doped calcium phosphate ceramic scaffold material, in particular to a preparation technology of a bone tissue engineering scaffold material with good pharmacological strontium element slow release and controllable structure, composition and degradation performance. Background technique [0002] When human civilization entered the 1990s, with the rapid development of bioengineering and genetic engineering technology and the high importance of human society on its own medical health, scholars began to innovate research ideas and get rid of the shackles of traditional biomaterial research methods , proposed another emerging method of developing human living tissues and organs - tissue engineering. The proposal of tissue engineering marks that the study of biomaterials has expanded from non-biologically viable materials to the field of materials with biological functions,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B38/00
Inventor 郭大刚徐可为憨勇罗峰
Owner XI AN JIAOTONG UNIV
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