Preparation process of degradable foam-like strontium-doped calcium phosphate ceramic bone holder material

Abstract

The present invention discloses the preparation process of bone tissue engineering rack material of degradable foamed Sr-doped calcium phosphate ceramic. It is prepared through bone cement copying foam structure process, and the Sr-doped apatite bone cement slurry as material includes solid phase particles of Ca4(PO4)2, CaPO4 and SrPO4 in certain molar ratio and liquid phase of 0.5-1.0 mol / L H3PO4 aqua in the solid / liquid ratio of 1.5-3.0. Polyurethane foam template is adopted. The final product is mixture of Sr-doped apatite and tricalcium strontium phosphate or the mixture of tricalcium strontium phosphate and calcium strontium pyrophosphate, and its component phase contents may be controlled through regulating the molar ratio of materials, solid / liquid ratio and phosphoric acid concentration so as to control the material degrading rate.

Description

technical field

[0001] The invention relates to a preparation technology of a degradable foam-like strontium-doped calcium phosphate ceramic scaffold material, in particular to a preparation technology of a bone tissue engineering scaffold material with good pharmacological strontium element slow release and controllable structure, composition and degradation performance. Background technique

[0002] When human civilization entered the 1990s, with the rapid development of bioengineering and genetic engineering technology and the high importance of human society on its own medical health, scholars began to innovate research ideas and get rid of the shackles of traditional biomaterial research methods , proposed another emerging method of developing human living tissues and organs - tissue engineering. The proposal of tissue engineering marks that the study of biomaterials has expanded from non-biologically viable materials to the field of materials with biological functions,...