Method for preparing porous hydroxyapatite/calcium pyrophosphate compound bone repair material

A technology of hydroxyapatite and calcium pyrophosphate, which is applied in the fields of medical science, tissue regeneration, prosthesis, etc., can solve problems such as the need to improve the matching of bone tissue growth speed, prolong the process of bone defect repair, refractory degradation and absorption, etc. Achieve excellent degradation performance, improve osteogenic activity, and achieve the effect of pure material components

Active Publication Date: 2016-05-11
KUNMING UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with clinically applied autologous bone and allogeneic bone, porous HA bone repair materials still have some disadvantages, such as the degradation rate is still relatively slow, and the matching with the growth rate of bone tissue needs to be improved; at the same time, the neutral or It is difficult to be degraded and absorbed in a weakly acidic medium, so that in a long period of time, the HA in the bone defect site is difficult to be replaced by new bone tissue, prolonging the process of bone defect repair

Method used

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  • Method for preparing porous hydroxyapatite/calcium pyrophosphate compound bone repair material
  • Method for preparing porous hydroxyapatite/calcium pyrophosphate compound bone repair material
  • Method for preparing porous hydroxyapatite/calcium pyrophosphate compound bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In this example, the process steps of the method for preparing porous HA / CPP composite bone repair materials by spark plasma sintering are:

[0034] (1) According to the mass percentage of hydroxyapatite 85% and calcium pyrophosphate 15%, weigh hydroxyapatite with purity ≥99.7% and average particle size of 10nm and coke with purity ≥99.7% and average particle size of 0.2μm. Calcium phosphate powder.

[0035] (2) Put the ceramic powder weighed in step (1) into the agate ball mill jar of the ball mill, add the agate ball according to the ball-to-battery ratio of 3:1, then add absolute ethanol, and then perform ball milling and mixing for 10 hours. After the slurry is dried, it is ground to obtain a mixed ceramic powder.

[0036] (3) According to the mass percentage of 55% of the mixed ceramic powder and 45% of ammonium bicarbonate obtained in step (2), weigh the mixed ceramic powder and ammonium bicarbonate powder with analytical purity and an average particle size of 500 μm.

...

Embodiment 2

[0043] In this example, the process steps of the method for preparing porous HA / CPP composite bone repair materials by spark plasma sintering are:

[0044] (1) According to the mass percentage of hydroxyapatite 85% and calcium pyrophosphate 15%, weigh hydroxyapatite with purity ≥99.7% and average particle size of 100nm and pyrophosphate with purity ≥99.7% and average particle size of 10μm. Calcium powder.

[0045] (2) Put the ceramic powder weighed in step (1) into the agate ball mill jar of the ball mill, add the agate ball according to the ball-to-battery ratio of 3:1, then add absolute ethanol, and then perform ball milling and mixing for 10 hours. After the slurry is dried, it is ground to obtain a mixed ceramic powder.

[0046] (3) According to the mass percentage of 45% of the mixed ceramic powder and 55% of ammonium bicarbonate obtained in step (2), weigh the mixed ceramic powder and ammonium bicarbonate powder with analytical purity and average particle size of 800 μm.

[004...

Embodiment 3

[0052] In this example, the process steps of the method for preparing porous HA / CPP composite bone repair materials by spark plasma sintering are:

[0053] (1) Weigh hydroxyapatite with a purity of ≥99.7% and an average particle size of 100nm and calcium pyrophosphate with a purity of ≥99.7% and an average particle size of 5μm according to the mass percentages of 95% hydroxyapatite and 5% calcium coke. powder.

[0054] (2) Put the ceramic powder weighed in step (1) into the agate ball mill tank of the ball mill, add the agate ball according to the ball-to-battery ratio of 3:1, then add absolute ethanol, and then perform ball milling and mixing for 9 hours. After the slurry is dried, it is ground to obtain a mixed ceramic powder.

[0055] (3) According to the mass percentage of 50% mixed ceramic powder and 50% ammonium bicarbonate obtained in step (2), weigh the mixed ceramic powder and ammonium bicarbonate powder with analytical purity and an average particle size of 600 μm.

[0056]...

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Abstract

The invention relates to a method for preparing a porous hydroxyapatite / calcium pyrophosphate compound bone repair material, and belongs to the technical field of biomedical material preparation. The method includes the steps that 85%-95% by mass of hydroxyapatite and 5%-15% by mass of calcium pyrophosphate ceramic powder are weighed and are subjected to ball milling to obtain mixed powder; then 45%-55% by mass of mixed powder and 45%-55% by mass of ammonium-bicarbonate pore forming agent powder are mixed to be even, and are pressed into a block pressed blank through a machine; the pressed blank is put into a graphite mold to be placed into a spark plasma sintering furnace to be sintered, the temperature is naturally cooled to the room temperature along with the spark plasma sintering furnace, demolding is carried out, and the porous hydroxyapatite / calcium pyrophosphate compound bone repair material is obtained. According to the method for preparing the porous hydroxyapatite / calcium pyrophosphate compound bone repair material, binding agents and template agents are avoided, ingredients are pure and free of detrimental impurities, the porosity is controllable between 10% and 30%, and the degradation rate is better matched with bone tissue growth; the good ossifying inducing capability is achieved, the technology is simple and easy to operate, and the porous hydroxyapatite / calcium pyrophosphate compound bone repair material can be used as a bone defect repair material for body hard tissue regeneration or reconstruction.

Description

Technical field [0001] The invention relates to a preparation method of a porous hydroxyapatite / calcium pyrophosphate composite bone repair material, and belongs to the technical field of biomedical material preparation. Background technique [0002] In recent years, with the rapid development of the national economy and the frequent occurrence of various work-related injuries and traffic accidents, in the clinical medical process, we often encounter bone defects caused by reconstruction or regeneration due to diseases or trauma, and a large amount of bone defect repair materials are needed. . At present, the most widely used bone defect repair materials in clinical applications are autologous bone and allogeneic bone, but there are problems such as insufficient source, bone donor area complications, transplant rejection, disease transmission and long fusion time, which limit its application. Therefore, it is necessary to research and develop new artificial bone repair materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/56A61L27/58
CPCA61L27/12A61L27/56A61L27/58A61L2430/02
Inventor 张玉勤孟增东谢辉罗丽琳秦利波刘伟
Owner KUNMING UNIV OF SCI & TECH
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