The invention discloses high-wear-resistant antibacterial acrylate paint. The high-wear-resistant antibacterial acrylate paint is prepared from the raw materials: an aqueous acrylate emulsion, alkyd resin, organosilicon modified unsaturated polyester resin, silica sol, cellulose acetate butyrate, polyvinyl pyrrolidone, modified nano-titania, calcium carbonate whiskers, octadecyl trimethyl ammonium chloride modified montmorillonite, hollow glass beads, zinc oxide, ethylene glycol mono-n-propyl ether, di-propanediol butyl ether, triethylene glycol monoethyl ether, an anti-settling agent, a humectant, an antifoamer, per-methoxylation melamine resin, 3,5-dimethyl-2-aminobenzoic acid, trimethylaniline, a leveling agent, vinyl triethoxysilane and deionized water. The high-wear-resistant antibacterial acrylate paint provided by the invention is high in hardness, good in wear resistance, excellent in antibacterial performance and long in service life.