Preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions

A calcium phosphate bone cement, silicate ion technology, applied in medical science, prosthesis and other directions, can solve the problems of no induced osteogenesis, expensive growth factors, and the existence of sudden release phenomenon, so as to promote osteogenesis and improve bone formation. Bone properties, the effect of improving mechanical strength

Active Publication Date: 2016-02-10
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The growth factor is expensive, and there is a burst release phenomenon after being compounded into CPC. It only has a certain effect of promoting osteogenesis in the early stage of material implantation, and does not have a long-term effect of inducing osteogenesis.

Method used

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  • Preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions
  • Preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions
  • Preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Select zinc silicate as an inorganic salt additive containing both zinc ions and silicate ions, and add it to the bone cement of the "partially crystalline calcium phosphate + anhydrous calcium hydrogen phosphate" system. The implementation steps include:

[0033] (11) A microwave hydrothermal method is used to prepare zinc silicate powder. Dissolve zinc acetate and ethyl orthosilicate in deionized water successively, the molar ratio of zinc to silicon is 2:1, and adjust the pH of the solution to 7 with ammonia. As the chemical reaction progresses, the solution gradually becomes a uniform white emulsion. The white emulsion was hydrothermally heated in a microwave at 160°C for 1 hour, and the white precipitate was washed with deionized water after the hydrothermal was completed and dried at 80°C to obtain the desired zinc silicate powder.

[0034] (12) Weigh 0.1 g of the zinc silicate powder prepared in step (11), weigh 0.9 g of the bone cement powder of the "partially cryst...

Embodiment 2

[0041] Select zinc-doped monocalcium silicate as an inorganic salt additive containing zinc ions and silicate ions, and add it to the bone cement of the "dihydrogen phosphate + α-tricalcium phosphate + calcium carbonate" system. The implementation steps include:

[0042] (11) A high-temperature solid-phase reaction method is used to prepare zinc-doped monocalcium silicate. Weigh a certain mass of zinc oxide and calcium silicate, where the molar ratio of zinc to calcium is 1:19. After the mixing is uniform, it is calcined at 1000° C. and kept for 4 hours to obtain the zinc-doped monocalcium silicate required for the experiment.

[0043] (12) Weigh 0.2 g of zinc-doped monocalcium silicate powder prepared in step (11), weigh 0.8 g of bone cement powder of the system of "dihydrogen phosphate + α-tricalcium phosphate + calcium carbonate", and It is evenly mixed. A 0.25mol / L disodium hydrogen phosphate solution was selected as the blending solution, and added to the zinc-doped monocalc...

Embodiment 3

[0050] Select zinc phosphate and dicalcium silicate as inorganic salt additives containing zinc ions and silicate ions, and add them to the "amorphous calcium phosphate + calcium hydrogen phosphate dihydrate" system bone cement. The implementation steps include:

[0051] (11) Weigh 0.05 g of dicalcium silicate, 0.05 g of zinc phosphate, and weigh 0.9 g of bone cement powder of the "amorphous calcium phosphate + calcium hydrogen phosphate dihydrate" system, and mix them evenly. A 0.1 mol / L potassium citrate solution was selected as the blending solution, and the liquid phase was added to the zinc phosphate and dicalcium silicate-containing bone cement powder prepared in this example according to the liquid-to-solid ratio of 0.4 mL / g, and blended Into a paste.

[0052] (12) Put the pastes prepared in step (11) into injectable instruments, respectively, and form and solidify the bone cement after injection.

[0053] Comparison sample:

[0054] (21) Weigh 1 g of bone cement powder of the...

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Abstract

The invention discloses a preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions. The preparation method comprises the following steps that (1) calcium phosphate bone cement powder, inorganic salt containing zinc ions and inorganic salt containing silicate ions are mixed evenly to obtain the calcium phosphate bone cement containing zinc and silicon elements, namely a solid phase; (2) the solid phase cement obtained through the step (1) and a liquid phase are blended, wherein the mass ratio of the liquid phase volume to the solid phase powder is 0.3-0.6 mL / g. The zinc ions and the silicate ions are simultaneously added into the calcium phosphate bone cement for the first time, the calcium phosphate bone cement has the advantages of having high mechanical strength and appropriate setting time and being capable of continuously releasing the zinc ions and silicate ions for a long time and controllable in release amount, and meanwhile the two different types of released functional ions can play roles of synergistically inhibiting bone absorption and promoting bone repair. Compared with traditional calcium phosphate bone cement, the calcium phosphate bone cement has more excellent bone defect repairing effect and wider clinical application prospect.

Description

Technical field [0001] The invention relates to the field of bone defect repairing medical materials, in particular to a method for preparing calcium phosphate bone cement that simultaneously releases zinc ions and silicate ions. Background technique [0002] Since Brown and Chow first reported on Calcium Phosphate Cement (CPC), CPC has received extensive attention from researchers. CPC is composed of solid phase powder and liquid phase. In clinical use, the two phases are mixed and blended to form a paste, and then implanted and filled into the bone defect site by surgery or injection equipment. CPC solidifies by itself at body temperature, gradually degrades in the body, guides the formation of new bone, and finally completes the repair of bone defects. CPC is a kind of bone defect filling and repairing material with good clinical application prospects because of its injectability, arbitrary shaping, in-situ isothermal self-curing properties and other properties that are diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/54
Inventor 叶建东张婧吴婷婷
Owner SOUTH CHINA UNIV OF TECH
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