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Method for preparing multifunctional sodium alginate stent embedded with drug-loaded microspheres by using 3D printing technology based on in-situ emulsification

A sodium alginate and 3D printing technology, which is applied in the fields of pharmaceutical formula, medical science, microcapsules, etc., can solve problems such as low osteogenic activity, poor mechanical properties of scaffolds, and surgical failures

Active Publication Date: 2021-09-10
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure sodium alginate scaffolds have poor mechanical properties and low osteogenic activity, so they are limited in practical application, and the constructed scaffolds lack antibacterial and anti-inflammatory activities, which are prone to bacterial infection and concurrent bone grafting. inflammatory response leading to surgical failure

Method used

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  • Method for preparing multifunctional sodium alginate stent embedded with drug-loaded microspheres by using 3D printing technology based on in-situ emulsification
  • Method for preparing multifunctional sodium alginate stent embedded with drug-loaded microspheres by using 3D printing technology based on in-situ emulsification
  • Method for preparing multifunctional sodium alginate stent embedded with drug-loaded microspheres by using 3D printing technology based on in-situ emulsification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Preparation of amino-modified polylactic acid: Dissolve poly-L-lactic acid particles in 1,4-dioxane solvent in a 60°C water bath to prepare a homogeneous solution with a concentration of 1 wt%. A 1.2 wt% ethylenediamine aqueous solution was added to the phase solution, reacted for 30 min, cooled to room temperature, and then placed in a freeze dryer at -80 °C to freeze-dry to obtain aminated polylactic acid.

[0022] 2) Preparation of printing paste: Weigh a certain amount of lecithin and sodium alginate and dissolve them in 4 wt% ethanol aqueous solution to obtain a lecithin-dissolved sodium alginate solution, and lecithin-dissolved sodium alginate solution The concentration of lecithin was 1 wt%. Dissolving the amino-modified polylactic acid and ibuprofen drug prepared in step 1) in 1,4-dioxane solvent to obtain a modified polylactic acid solution dissolved with ibuprofen drug, wherein the concentration of the modified polylactic acid is is 2 wt%, and the concentr...

Embodiment 2

[0025] 1) Preparation of amino-modified polylactic acid: Dissolve poly-L-lactic acid particles in 1,4-dioxane solvent in a 60°C water bath to prepare a homogeneous solution with a concentration of 1 wt%. A 1.2 wt% ethylenediamine aqueous solution was added to the phase solution, reacted for 30 min, cooled to room temperature, and then placed in a freeze dryer at -80 °C to freeze-dry to obtain aminated polylactic acid.

[0026] 2) Preparation of printing paste: Weigh a certain amount of lecithin and sodium alginate and dissolve them in 4 wt% ethanol aqueous solution to obtain a lecithin-dissolved sodium alginate solution, and lecithin-dissolved sodium alginate solution The concentration of lecithin was 3 wt%. Dissolving the amino-modified polylactic acid and minocycline drug prepared in step 1) in 1,4-dioxane solvent to obtain a modified polylactic acid solution in which minocycline drug is dissolved, wherein the modified polylactic acid The concentration of lactic acid was 3 ...

Embodiment 3

[0029] 1) Preparation of amino-modified polylactic acid: Dissolve poly-L-lactic acid particles in 1,4-dioxane solvent in a 60°C water bath to prepare a homogeneous solution with a concentration of 1 wt%. A 1.2 wt% ethylenediamine aqueous solution was added to the phase solution, reacted for 30 min, cooled to room temperature, and then placed in a freeze dryer at -80 °C to freeze-dry to obtain aminated polylactic acid.

[0030] 2) Preparation of printing paste: Weigh a certain amount of lecithin and sodium alginate and dissolve them in 4 wt% ethanol aqueous solution to obtain a lecithin-dissolved sodium alginate solution, and lecithin-dissolved sodium alginate solution The concentration of lecithin is 2 wt%. Dissolving the amino-modified polylactic acid, loxoprofen sodium and vancomycin drug prepared in step 1) in 1,4-dioxane solvent to obtain loxoprofen sodium and vancomycin drug dissolved Modified polylactic acid solution, wherein the concentration of modified polylactic aci...

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Abstract

The invention discloses a method for preparing a multifunctional sodium alginate stent embedded with drug-loaded microspheres by using a 3D printing technology based on in-situ emulsification, and aims to provide a preparation method of a multifunctional bone defect repair stent material. The method is characterized by comprising the following steps: by taking a bioactive substance lecithin as an emulsifier, dispersing an amination modified polylactic acid solution dissolved with an antibacterial or anti-inflammatory drug into a sodium alginate solution to form a stable emulsion, then constructing the sodium alginate stent embedded with the drug-loaded microspheres in situ by utilizing a low-temperature 3D printing technology, and using divalent strontium ions (Sr<2+>) as a cross-linking agent to improve the mechanical properties and osteogenic activity of the stent. The method has the characteristics that the prepared tent can be individually designed according to the characteristics of the bone defect part of a patient, and the prepared stent has multiple functions of good biological activity, osteogenic ability, mechanical property, antisepsis, anti-inflammation and the like, and has potential application prospects in the field of bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of bone repair biomaterials, and in particular relates to a method for preparing a multifunctional sodium alginate scaffold embedded with drug-loaded microspheres by using a 3D printing technology based on in-situ emulsification. Background technique [0002] The repair and treatment of large-sized bone defects caused by partial bone loss in patients caused by various traumas, tumor resections, or infections is a huge challenge in clinical medicine at present. Due to the limitations of autologous bone grafting, allogeneic bone grafting and artificial bone grafting in the repair of such bone defects, their clinical application is limited due to the limited donor area, easy immune rejection, and lack of osteoinductive activity. Novel regenerative bone defect repair materials with bioactivity and osteogenic ability have become an urgent problem in the field of bone repair. With the continuous development of ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/54A61L27/56A61L27/58B33Y70/00B33Y80/00
CPCA61L27/18A61L27/20A61L27/54A61L27/58A61L27/56B33Y70/00B33Y80/00A61L2300/406A61L2300/602A61L2300/622A61L2430/02C08L67/04C08L5/04
Inventor 陈顺玉赵利华谢春玲梁青爽肖秀峰
Owner FUJIAN NORMAL UNIV
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