Composite material for processing micro-type bone retention pin and preparation method of composite material

Abstract

The invention discloses a composite material for processing a micro-type bone retention pin and a preparation method of the composite material. The composite material is obtained by the following steps: adding a biologically-active inorganic material and a zeolitic imidazolate structural material ZIF-8 into a solution of a binding material with biological activity, performing stirring at pH of 8-10 and room temperature to make the ZIF-8 coat the biologically-active inorganic material by the binding material with biological activity during polymerization, adding a bone scaffold substrate material, performing uniform dispersion in a high-speed mixing machine, and performing banburying mixing granulation to obtain the composite material. The composite material provided by the invention contains the bone scaffold substrate material, the biologically-active inorganic material and the zeolitic imidazolate structural material ZIF-8, so that the substrate of the bone scaffold substrate material can be strengthened, the early degradation of the material can be delayed, the osteogenesis ability of a body guided by the material and the biocompatibility can be improved, and the inducibility and antibacterial property are given to the bone scaffold substrate material; and the preparation method is simple, has low costs, and is convenient for promotion and application.

Description

technical field [0001] The invention belongs to the technical field of processing bone-retaining screw materials and its preparation, and in particular relates to a composite material for processing miniature bone-retaining screws and a preparation method thereof. Background technique [0002] Aging diseases such as osteoporosis are one of the main causes of fractures, and an osteoporotic fracture occurs every 3 seconds in the world. In bone repair, the miniature bone fixation screw is a very important and fine fixation device, which is small in size (one-dimensional size is less than 100 μm), light in weight (generally no more than 100 mg), and high in precision, which is difficult to be processed by traditional processing methods. Large-scale preparation. Therefore, for fractures in small parts such as the spine, jaw, and ribs, the processing accuracy, mechanical strength, and biological properties of the micro-bone fixation screw are the key points and difficulties for t...

AI Technical Summary

Problems solved by technology

[0003] Traditional bone fixation nails are mostly made of alloy or ceramic materials, the surface bioactivity is not high, not only lacks osteoinductivity, but also needs to be removed through a two-stage operation, which increases the pain of the patient, and the cavity left by the operation also has a potential risk of fracture

Although the bone fixation nails with absorbable polymer materials as the main body are degradable and do not require secondary surgery to remove them, unfortunately, the mechanical strength is not good, only 40-60 MPa, and usually can only be used for muscle tension. less forceful fracture site

Another example is the chemical composition of Japan's "GRANDFIX" bone fixation nail, which is PLA. Although it has the advantages of high biocompatibility and no side effects, it has no osteoinductive properties because it has no osteoinductive materials.

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