35 results about "Imidazolate" patented technology

The invention discloses a carbon quantum dot / metal organic framework composite material as well as a preparation method and application thereof, and the method is characterized in that carbon quantum dots derived from waterborne polyurethane are embedded into a zeolite imidazate framework 8 to prepare the carbon quantum dot / metal organic framework composite material. The composite material can be used as a ratio type fluorescent probe for trace detection of tetracycline, a dual-emission fluorescence signal of the probe is derived from tetracycline which quenches blue fluorescence of puCDs at 450 nm through an inner filter effect, and the coordination effect between Zn < 2 + > and tetracycline triggers an aggregation-induced emission effect, so that new fluorescence emission is generated, and the detection sensitivity is improved. The intensity of the two signals changes in proportion to the concentration of tetracycline, the wide linear concentration detection range and the low detection limit are achieved, the probe has the high recovery rate and the large adsorption capacity in detection, the problems that a traditional detection method is insufficient in sensitivity, poor in anti-interference capacity, high in cost and the like are solved, and the application prospect is wide. A new thought is provided for constructing a ratio type fluorescent probe with a removal function.

The invention relates to a preparation method of a fluorescence sensor. The invention relates to a preparation method of a portable pesticide detection fluorescence sensor of silver nanocluster (AgNCs) at zeolite imidazolate skeleton (ZIF) at polydopamine (PDA) and application of the portable pesticide detection fluorescence sensor in on-site rapid detection of 2, 4-dichlorophenoxyacetic acid (2, 4-D), and belongs to the technical field of fluorescence sensors. The method comprises the following steps: wrapping AgNCs with ZIF, and modifying the surface of the AgNCs with dopamine to form an AgNCs-ZIF-PDA composite material with high stability, high fluorescence enhancement, high enzyme responsiveness and high controllability; then, the material is integrated into a nano clay-acrylamide hydrogel matrix with high fitness, and a sensor with an adjustable shape is constructed. The sensor can be adaptively attached to the surface of a plant and is used for long-term in-situ monitoring of 2, 4-D pesticide. And in combination with an image processing algorithm, the system realizes accurate tracking of the tomato plant surface 2, 4-D degradation process, and the detection limit reaches 23.3 ng / mL. According to the invention, non-intrusive and low-cost technical support is provided for crop health management and sustainable precision agriculture.

The invention discloses multi-adsorption-site nitrogen-doped porous carbon, a preparation method and application in iodine adsorption, and the preparation method comprises the following steps: carrying out primary calcination on a zeolite imidazate framework material, mixing with potassium hydroxide, and then carrying out secondary calcination to obtain the multi-adsorption-site nitrogen-doped porous carbon. According to the invention, a zeolite imidazate framework material is used as a precursor, potassium hydroxide is introduced for high-temperature calcination activation treatment, the obtained product inherits a rhombic dodecahedron framework of ZIF-8, a continuous through pore system and a nitrogen-doped carbon material with high pyrrole nitrogen content are formed, and the static adsorption capacity of the nitrogen-doped carbon material to iodine can reach 7.99 g / g.

The application discloses a polyacid zeolite imidazolate framework loaded monatomic catalyst and a preparation method and application thereof, and belongs to the technical field of catalysts. The preparation method of the catalyst is as follows: (1) preparing a zeolite imidazolate framework material; (2) mixing the dried zeolite imidazolate framework material and a metal salt in a solvent and stirring; then adding a heteropoly acid, controlling the pH in the system to be 5-7, and performing a solvothermal reaction under the condition of 80-120 DEG C; after the reaction is completed, cooling and centrifugal separation are performed to obtain a precipitate; and (3) performing calcination treatment on the precipitate to obtain the polyacid zeolite imidazolate framework loaded monatomic catalyst. The polyacid zeolite imidazolate framework loaded monatomic catalyst prepared by the method has high catalytic activity, high selectivity and good cycle stability, and has a good application prospect in acetyl propionate esterification reaction.

The invention belongs to the technical field of electro-catalysis, and particularly discloses a Cu nanoparticle / acidified carbon nanotube catalyst and a preparation method and application thereof.According to the preparation method, acidified pretreated carbon nanotubes with good conductivity and high specific surface area are selected as a substrate, CuO nanoparticles are evenly loaded through a hydrothermal method, and the Cu nanoparticle / acidified carbon nanotube catalyst is obtained; and growing a zeolite imidazate framework material-8 (ZIF-8) on the surface of the CuO nanoparticle-loaded carbon nanotube in situ, and regulating the thickness of an ultrathin nitrogen-carbon layer on the surface and coordination of Cu-N by regulating the calcining temperature and time. According to the Cu nanoparticle / acidified carbon nanotube catalyst as well as the preparation method and the application thereof, the Cu nanoparticles are encapsulated in a confined manner, so that long-service-life electrically-driven CO2 is converted into a high-added-value C2 + product, catalytic active sites of the Cu nanoparticles are fully exposed, the charge transfer rate is increased, and the intrinsic activity of the Cu active sites is improved.

The invention discloses a method for preparing polyimide by reducing the imidization temperature of polyamide acid, which comprises the following steps: carrying out polymerization reaction on an aromatic diamine monomer and an aromatic dianhydride monomer in an organic solvent to generate polyamide acid, and then adding ZIFs to obtain a polyamide acid solution / ZIFs compound; the polyamide acid solution / ZIFs compound solvent is volatilized to obtain a polyamide acid / ZIFs compound, and then the polyamide acid / ZIFs compound is heated, so that the polyimide acid in the polyamide acid / ZIFs compound is subjected to imidization reaction to generate polyimide. By adopting the method to prepare the polyimide, the reaction temperature for generating the polyimide through imidization of polyamide acid can be obviously reduced, namely, the imidization temperature is reduced to 220 DEG C from the traditional imidization temperature greater than 300 DEG C, and the obtained polyimide has good thermal stability and transparency and can be applied to the high and new technical fields of display devices, photoelectrons, microelectronics, aerospace and the like.

The application discloses a method for preparing monophenol chemicals by catalyzing lignin depolymerization through zeolite imidazolate framework material derivatives. The method uses lignin as raw material, uses zeolite imidazolate framework material derivatives as catalyst, and uses small-molecule organic alcohol as hydrogen-donor solvent. After inert gas replacement and pressure charging to 0.5-3 MPa, the reaction temperature is controlled to 200-240 DEG C, and stirring is carried out for 2-10 h, so that selective depolymerization of lignin can be realized without external hydrogen, and monophenol chemicals mainly composed of 4-propyl-2,6-dimethoxyphenol are obtained. The method is environment-friendly, stable in performance, highly efficient in catalysis and high in selectivity, and realizes selective conversion of lignin into monophenol chemicals mainly composed of 4-propyl-2,6-dimethoxyphenol without external hydrogen.

The invention discloses a fused salt heat storage material based on a lithium nitrate and polyvinylidene fluoride hybridized zeolite imidazate framework structure. The fused salt heat storage material comprises the following components in parts by mass: 20-35 parts of sodium nitrate, 25-40 parts of potassium nitrate, 10-20 parts of lithium nitrate, 10-25 parts of calcium nitrate and 0.5-2 parts of a polyvinylidene fluoride hybridized zeolite imidazate framework structure material, the polyvinylidene fluoride hybridized zeolite imidazate skeleton structure material is prepared by the following steps: step 1, adding a zinc nitrate solution into a 2-methylimidazole solution under a stirring condition, standing, carrying out a crystallization reaction, washing and drying to obtain a zeolite imidazate skeleton structure material; and step 2, mixing the zeolite imidazate skeleton structure material, polyvinylidene fluoride and dimethylformamide, and drying to obtain the polyvinylidene fluoride hybridized zeolite imidazate skeleton structure material. The fused salt heat storage material is high in specific heat capacity and low in viscosity.

The application discloses a preparation method of a dendritic T-NC and ionic liquid Pt / C catalyst and application thereof, and generates a zeolite imidazolate framework material (ZIF-8) by reacting a zinc salt with 2-methyl imidazole, and composites the ZIF-8 with a conductive carbon material. When high-temperature pyrolysis is carried out under an inert atmosphere, zinc species in the ZIF-8 volatilizes, thereby etching out abundant multi-stage pores in the carbon matrix, and forming a unique dendritic nitrogen-doped carbon structure (T-NC). The structure can effectively load and stabilize platinum nanoparticles. Subsequently, by infiltrating ionic liquid, the high ionic conductivity and interface characteristics of the ionic liquid are utilized to enhance the proton conduction of a catalytic layer and optimize a mass transfer process. The method is simple in process, and raw materials are easy to obtain. Through the synergy of the carrier structure and the interface microenvironment, the prepared catalyst realizes comprehensive improvement in oxygen reduction reaction activity, durability and low-humidity adaptability, and provides a feasible material solution for a high-performance, long-life and low-cost proton exchange membrane fuel cell.

The application relates to the technical field of analytical detection, in particular to an electrochemical gas sensor for detecting linalool and a preparation method thereof. The preparation method is to prepare the electrochemical gas sensor after modifying a molecular imprinting film-zeolite imidazolate framework-8-multi-walled carbon nanotube-zinc oxide (MIP-ZIF-8-MWCNT-ZnO) composite material on the surface of an electrode. The electrochemical gas sensor can sensitively and accurately detect the content of linalool gas released by plants, realizes stable and accurate detection of linalool with high specificity and high sensitivity in a complex environment, and has a wide application prospect.

The invention provides a waterborne polyurethane emulsion as well as a preparation method and application thereof, and particularly relates to a waterborne polyurethane emulsion as well as a preparation method thereof and a waterborne polyurethane composite adhesive. The waterborne polyurethane emulsion is prepared from the following raw materials in percentage by mass: 15.0 to 16.0 percent of polycarbonate polyol, 3.0 to 5.5 percent of diisocyanate, 4.0 to 6.0 percent of a hydrophilic compound, 0.5 to 2.3 percent of a chain extender, 0.4 to 0.6 percent of a neutralizing agent, 20 to 25 percent of a diluent, 0.25 to 0.8 percent of an aminated zeolite imidazate framework material precursor and the balance of a solvent. According to the preparation method disclosed by the invention, the preparation raw materials of the waterborne polyurethane emulsion are designed, and the waterborne polyurethane emulsion with excellent performance is prepared by virtue of a synergistic effect of all the components, so that the waterborne polyurethane composite adhesive with excellent hydrolysis resistance and mechanical property is prepared.

The application discloses a controllable release nano-enzyme hydrogel for promoting chronic wound healing of diabetes, and a preparation method and application thereof. The hydrogel is prepared according to the following steps: (1) preparing Pd-ZIF8@DNase I nano-enzyme particles; (2) dissolving four-arm-polyethylene glycol-o-phenylenediamine (4a-PEG-OPA) in a tris-hydroxymethyl aminomethane-hydrochloric acid (Tris-HCl) buffer solution, adding 3-aminobenzoic acid solution, and forming a hydrogel network through a Schiff base reaction; and (3) uniformly dispersing the Pd-ZIF8@DNase I nano-enzyme particles obtained in the step (1) in the hydrogel system to obtain Pd-ZIF8@DNase I hydrogel. The controllable release nano-enzyme hydrogel based on the "enzyme-induced defective metal organic framework (MOF)" structure of zeolite imidazolate framework structure material 8 (ZIF8) with high electron transfer efficiency can target neutrophil extracellular traps (NETs) and has antioxidant activity, and can promote chronic wound healing of diabetes.

The application belongs to the technical field of photocatalytic material preparation, and particularly relates to a Co-CN photocatalyst based on ZIF-L derivation and a preparation method and application thereof. The application uses melamine, dimethyl imidazole and cobalt nitrate as raw materials, and utilizes water bath heating, program temperature control and vacuum calcination to synthesize a CN composite photocatalytic material modified by Co monatomic derived from zeolite imidazolate framework structure material (ZIF-L). The application has the advantages of simple process, convenient operation, low cost, non-toxicity, harmlessness, short reaction time and the like. The prepared photocatalytic material has excellent photocatalytic degradation performance on tetracycline in a water environment. When the photocatalytic material is applied to removal of tetracycline pollutants in water, the removal efficiency is improved while energy consumption and reaction cost are reduced, and the application is green, environmentally friendly and meets the environmental friendly requirements.

The application provides a platinum-based catalyst and a preparation method and application thereof, and belongs to the technical field of fuel cells. The preparation method comprises the following steps: mixing a polymer solution, a conductive agent and a zeolite imidazolate framework material to obtain an electrostatic spinning solution; electrostatic spinning is performed on the electrostatic spinning solution, and then heat treatment is performed to obtain composite nanofibers containing metal nanoparticles or metal oxide nanoparticles; the composite nanofibers, a platinum source and an organic solvent are mixed to perform a reduction reaction, and the platinum-based catalyst is obtained. The polymer solution, the conductive agent and the zeolite imidazolate framework material are mixed, and the uniform distribution of various components on the nanoscale can be ensured by means of the electrostatic spinning technology, which is beneficial to the formation of a stable and efficient three-phase interface; the metal nanoparticles or the metal oxide nanoparticles obtained by conversion are combined with platinum particles, so that more active sites of the catalyst are exposed, and the efficient performance of the catalytic reaction is promoted.

The application discloses a zeolite-like imidazolate framework compound and a preparation method and application thereof. The preparation method of the zeolite-like imidazolate framework compound comprises the following steps: S1, using a conductive substrate as a working electrode and forming a standard three-electrode system with a reference electrode and a counter electrode, using a metal ion solution and a nitrogen-containing organic ligand solution as electrolyte solutions, and constructing a reactor; S2, synthesizing the zeolite-like imidazolate framework compound on the conductive substrate in S1 through an electrochemical method; wherein, the solvent of the metal ion solution and the nitrogen-containing organic ligand solution in S1 is water or a mixed solution of water and a weak polar solvent, and the weak polar solvent is at least one of methanol, acetonitrile and acetone. By using the three-electrode system and the aqueous electrolyte solution to jointly act, the zeolite-like imidazolate framework compound with specific morphology can be efficiently synthesized under mild conditions, and when the zeolite-like imidazolate framework compound is applied to the detection of uric acid, the zeolite-like imidazolate framework compound has good response to uric acid.

The invention discloses a ZIF-8 nano-drug delivery system co-loaded with adriamycin and siTDRKH as well as a preparation method and application of the ZIF-8 nano-drug delivery system, and belongs to the technical field of biological medicines and nano-materials. According to the nano-drug delivery system, a zeolite imidazate framework material ZIF-8 is used as a carrier, a chemotherapeutic drug adriamycin is entrapped in a framework by using a porous structure of the zeolite imidazate framework material ZIF-8, and small interfering RNA of a targeted TDRKH gene is loaded on the surface through an electrostatic adsorption effect. The structure has high pH responsiveness: the structure is kept stable in a normal physiological environment (pH 7.4), and drugs are prevented from leaking in advance; once entering a tumor subacid environment (pH 6.5) or lysosome environment (pH 5.0), the ZIF-8 skeleton immediately responds and disintegrates, and fixed-point and synergistic release of the loaded drug is realized.

The invention discloses a preparation method and application of a dendritic T-NC and ionic liquid Pt / C catalyst, zinc salt and 2-methylimidazole react to generate a zeolite imidazate framework material (ZIF-8), and the zeolite imidazate framework material (ZIF-8) is compounded with a conductive carbon material. And when high-temperature pyrolysis is carried out in an inert atmosphere, zinc species in the ZIF-8 volatilizes, so that rich multi-stage pore channels are etched in a carbon matrix, and a unique nitrogen-doped carbon structure (T-NC) is formed. The structure can effectively load and stabilize platinum nanoparticles. And then, by infiltrating the ionic liquid, the proton conduction of the catalyst layer is enhanced and the mass transfer process is optimized by utilizing the high ionic conductivity and interface characteristics of the ionic liquid. According to the present invention, the method has characteristics of simple process and easily available raw materials, the oxygen reduction reaction activity, the durability and the low humidity adaptability of the prepared catalyst are completely improved through the cooperation of the carrier structure and the interface microenvironment, and the feasible material solution is provided for the proton exchange membrane fuel cell with characteristics of high performance, long service life and low cost.

The application discloses a preparation method of a high-corrosion-resistance and wear-resistance magnesium alloy anodic oxidation composite coating. The method is characterized in that: a magnesium alloy is used as an anode, and an anodic oxidation coating is prepared by using an electrochemical method; then, a hydrothermal method is used, and zinc nitrate is used as a zinc ion source to prepare a rice flower-shaped zinc oxide intermediate layer on the sample subjected to anodic oxidation treatment, so as to serve as a growth site of a metal organic framework; finally, the sample containing the anodic oxidation layer and the transition layer is placed in a methanol solution containing dimethyl imidazole to perform a secondary solvothermal reaction, a zeolite imidazolate framework is synthesized on the surface of the sample, and a novel composite coating is obtained. The zeolite imidazolate framework can be uniformly distributed on the surface of the coating, and has strong combination capacity with the coating; the composite coating can not only improve the corrosion resistance of the material, but also significantly improve the wear resistance of the material, and has positive significance for promoting the application of the magnesium alloy as a medical degradable implant material.

The application discloses a P-region element reinforced double-atomic catalyst, a preparation method and application thereof, and belongs to the field of catalysts, and solves the problem of poor selectivity of hydrogen peroxide produced by traditional single-atomic catalysts based on transition metals in electrocatalytic two-electron oxygen reduction. In the application, cobalt and gallium elements are introduced into a zeolite imidazolate precursor by an ion exchange method, the coordination environment of the catalyst is regulated by introducing a sulfur species, and finally, the P-region element reinforced double-atomic catalyst is synthesized by high-temperature annealing. The application also discloses application of the catalyst in electrocatalytic two-electron oxygen reduction. The catalyst has the advantages of high hydrogen peroxide selectivity and high hydrogen peroxide production rate when used in electrocatalytic two-electron oxygen reduction, which has far-reaching significance for expanding the application scenarios of the P-region element catalyst in the field of electrocatalysis.

The application relates to the technical field of cutting fluids, and discloses a modified rapeseed oil-based cutting fluid and a preparation method thereof. The components of the modified rapeseed oil-based cutting fluid include modified rapeseed oil, an antioxidant, extreme pressure and wear-resistant agent, an emulsifier, a rust inhibitor, a pour point depressant, a defoaming agent and water; the modified rapeseed oil is obtained by modifying rapeseed oil through a zinc-based zeolite imidazolate skeleton calcined derivative and dodecylboronic acid pinacol ester. The zinc-based zeolite imidazolate skeleton calcined derivative is used as a heterogeneous catalyst, and the dodecylboronic acid pinacol ester is introduced as a multifunctional modifier. The two can realize directional epoxidation and closed-loop modification of the stable structure of the epoxy group, improve the oxidation stability, simultaneously optimize the low-temperature fluidity, and solve the technical contradiction that the traditional modification is stable in oxidation but poor in low-temperature performance.

The present application provides a kind of solid waste-based asphalt composite modifier and its preparation method, by mass fraction, including the following raw material components: surface composite modified ceramic polishing brick powder 40~70 parts;Zeolite imidazolate skeleton powder 3~8 parts;Alkali-activated geopolymer porous powder 15~25 parts;Nano TiO2 / ZSM-5 composite photocatalyst 2~6 parts;Silane coupling agent modified graphene 0.5~2 parts.The present application uses ceramic polishing brick powder, alkali-activated geopolymer porous powder and zeolite imidazolate skeleton material as main component, introduces nano TiO2 / ZSM-5 composite photocatalyst as catalytic active center.The modifier can still maintain a certain purification capacity in weak light environment, so as to realize the sustained purification of asphalt flue gas pollutants.

The invention provides a high-stability wearable lactic acid electrochemical sensor. A sensing interface of the sensor is prepared by sequentially dispensing a lactic acid sensing liquid and a film forming liquid on the surface of a carbon electrode, and the lactic acid sensing liquid is composed of a zeolite imidazate frame-90 (ZIF-90 at LDH) composite material for packaging lactic dehydrogenase, heme iron (Hematin) and a gel reaction liquid containing beta-nicotinamide adenine dinucleotide (NAD +). The film forming liquid is composed of ammonium persulfate and tetramethylethylenediamine. According to the method, lactic acid in a sample is oxidized by using ZIF-90 coated LDH on a sensing interface to generate pyruvic acid and a reducing coenzyme NADH, the NADH and Hematin are further subjected to an oxidation reaction, a current signal is generated on an electrode, and finally quantitative analysis is performed on the lactic acid in the biological sample based on a correction curve. The lactic acid electrochemical sensor provided by the invention has excellent detection stability and good environmental adaptability, and has a good application prospect in the field of development of wearable lactic acid sensors.

A single atom nanozyme includes an alkaline earth metal single atom loaded on a carbon material, in which the alkaline earth metal is calcium, magnesium, or barium, and the carbon material is nitrogen-doped and can be selected from imidazolate framework (ZIF), carbon fiber, carbon nanotube, graphene, carbon black, and reduced graphene oxide. Also provided is a method for preparing the single atom nanozymes, and a method of tumor catalytic therapy using the single atom nanozymes.

The invention relates to a light-cured hydrogel scaffold. The light-cured hydrogel scaffold comprises collagen, o-nitrobenzyl alcoholized polyethylene glycol and nano-particles, wherein the collagen is prepared from collagen, o-nitrobenzyl alcoholized polyethylene glycol and o-nitrobenzyl alcoholized polyethylene glycol; the collagen is prepared from phenylboronic acid grafted methacrylated collagen; the nano-particles comprise zeolite imidazolium salt skeleton-8 nano-particles which are coated by polydopamine and are adsorbed with epigallocatechin gallate, and the zeolite imidazolium salt skeleton-8 nano-particles comprise zeolite imidazolium salt skeleton-8 nano-particles. The photocuring hydrogel stent can be suitable for repairing complex infectious oral mucosa injury.

The invention relates to a calcium ion zeolite imidazole skeleton composite hemostatic dressing as well as a preparation method and application thereof, and belongs to the field of biomedical materials. The technical problems that an existing hemostatic material is low in blood coagulation efficiency and single in hemostatic effect are solved. The composite hemostatic dressing comprises a cotton fiber substrate and Ca-ZIF-8 nanoparticles loaded on the surface and fiber gaps of the cotton fiber substrate. Ca < 2 + > is doped into a ZIF-8 skeleton, is loaded on cotton fibers in an in-situ growth manner, and has dual mechanisms of physical adsorption and physiological coagulation promotion: a ZIF-8 porous structure rapidly adsorbs plasma moisture to enrich platelets and coagulation factors, Ca < 2 + > is used as a coagulation factor IV to activate a coagulation cascade reaction, and Ca < 2 + > and the coagulation factor IV have a synergistic effect. The preparation method is simple, the cost is controllable, the obtained dressing is stable in structure and good in biocompatibility, the blood coagulation index of an in-vitro blood coagulation experiment is close to 1%, and the dressing is suitable for an incompressible hemorrhage scene.

The invention discloses a method for synchronously improving strength and toughness of recycled PET, and belongs to the field of polymer materials. The preparation method comprises the following steps: mixing zeolite imidazole skeleton-8 (ZIF-8) with a polypropylene glycol diglycidyl ether (PPG-DGE) solution, drying, and then blending with recycled PET (Polyethylene Terephthalate) under a melting condition. As the ZIF-8 and the PPG-DGE have synergistic nucleation, chain extension and flexibility improvement effects, the tensile strength of the obtained composite material is improved, and the ductility is also improved.

The application discloses a method for simultaneously improving the strength and toughness of recycled PET, and belongs to the field of polymer materials. The method comprises the following steps: mixing zeolite imidazolate framework-8 (ZIF-8) with a polypropylene glycol diglycidyl ether (PPG-DGE) solution, drying the mixture, and then blending the mixture with recycled PET under a melting condition. Due to the synergistic nucleation, chain extension and flexibility improvement of the ZIF-8 and the PPG-DGE, the tensile strength of the obtained composite material is improved, and the ductility of the composite material is also improved.

The invention relates to an amphiphilic ZIF composite material demulsifier and a preparation method thereof, and belongs to the technical field of oil and gas field produced liquid treatment. The demulsifying agent takes a cobalt-based zeolite imidazate framework material (ZIF-67) as a carrier, is endowed with a super-hydrophobic surface through normal hexane modification, and is loaded with hydrophilic ferroferric oxide nanoparticles to form a composite material with hydrophilic and hydrophobic characteristics. The preparation method comprises the following steps: synthesis of Fe3O4 nanoparticles, compounding of ZIF-67 and Fe3O4, and surface modification. The material can be efficiently adsorbed on an oil-water interface, destroys the stability of an emulsion, realizes rapid oil-water separation, has a magnetic recovery function, can be repeatedly used, and has the advantages of high efficiency, environmental friendliness and low cost.

This invention discloses a size-controllable zeolite-like imidazole ester framework material and its preparation method. The preparation method includes the following steps: Step 1, dissolving an organic ligand in a solvent to obtain an organic ligand solution; Step 2, adding a metal salt to the organic ligand solution under stirring conditions, and reacting at room temperature to obtain a suspension; Step 3, sequentially centrifuging, washing, and drying the suspension to obtain the zeolite-like imidazole ester framework material. The metal salt is selected from any one or two of cobalt salts and zinc salts. The organic ligand is selected from any one or more of imidazole, 2-methylimidazole, 2-ethylimidazole, 2-nitroimidazole, imidazole-2-carboxaldehyde, and benzimidazole. This invention, without adding other raw materials or changing the reaction conditions, can successfully synthesize zeolite-like imidazole ester framework materials of different sizes simply by precisely controlling the concentration of the reaction precursor (i.e., imidazole derivative and coordinating metal ions). The control mechanism is simple and clear.

Relates to the technical field of oral medicine and oral medical products, in particular to a targeted nano-enzyme antibacterial agent with an oral flora level self-adaptive regulation function and a preparation method of the targeted nano-enzyme antibacterial agent. Specifically, a nitrogen-doped zeolite imidazate framework material is used as a carrier, and the bimetallic monatomic nano-enzyme is prepared through a pyrolysis method; the antibacterial peptide is used as a surface anchoring body and is modified on the surface of the nano-enzyme, so that the multifunctional nano-enzyme with high targeting colonization capability, efficient antibacterial biofilm and antibacterial effect is obtained. The invention also relates to a pharmaceutical composition, an antibacterial agent and an oral care product containing the nano-enzyme.