Quercetin drug-loading system based on copper sulphide-metal organic frame material

A metal-organic framework and drug-carrying system technology, applied in the field of medicine, to achieve the effects of low cytotoxicity, improved anti-cancer effect, and good curative effect
CN108524935AActive Publication Date: 2018-09-14SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2018-09-14

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Abstract

The invention discloses a quercetin drug-loading system based on a copper sulphide-metal organic frame material. A metal organic frame zeolite imidazolate framework material (ZIF-8) is generated on the surfaces of copper sulphide nano-particles (CuS NPs) as a photothermal preparation to obtain a CuS@ZIF-8 carrier, quercetin is adsorbed into a carrier, and then is modified by a stabilizer and a targeting agent FA-BSA, and thus, a nano delivery system (FA-BSA / CuS@ ZIF-8) with a targeting active effect and pH response can be formed. The water solubility and the chemical stability of the quercetinare improved, good curative effect of treating tumors by combination of phototherapy and chemotherapy can further be played, meanwhile, drug can be rapidly released under the condition of low pH in atumor microenvironment, the tumor cell intake of a pharmaceutic preparation is further enhanced, and the quercetin drug-loading system based on the copper sulphide-metal organic frame material has low toxicity to normal cells, and is good in biological compatibility.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the preparation, characterization and in vitro evaluation of the anti-tumor effect of a quercetin drug-loading system based on copper sulfide nanoparticles metal-organic framework materials. Background technique

[0002] Cancer is a major killer that threatens human life and health in today's society, and its morbidity and mortality have increased year by year in recent years. Among various treatment methods, chemotherapy is one of the most effective ways to inhibit tumor cell proliferation and promote tumor cell apoptosis by using chemical drugs through different mechanisms of action, such as interfering with DNA replication. However, most anticancer drugs have severe side effects in clinical practice, such as skin and mucous membrane reactions, hair loss, and side effects on various organs. Therefore, there is an urgent need to find and develop new anticancer drugs.

[0003] ...

Claims

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