10results about How to "Low biocompatibility" patented technology

The invention relates to a medical magnetic drive capsule endoscope coated with a lubricating soft shell and a preparation method of the medical magnetic drive capsule endoscope. The medical magnetically-driven capsule endoscope comprises an inner shell, an endoscope assembly, a water-soluble protective cover, a medicine applying assembly and a hydrogel shell, the inner shell is provided with a sealing cavity and a pesticide applying cavity; the endoscope assembly is located in the sealing cavity and comprises a camera module and an illumination module. The inner shell is provided with a pesticide application window which is communicated with the pesticide application cavity and faces the second direction, and the water-soluble protective cover is connected with the inner shell and covers the pesticide application window; the pesticide applying assembly is located in the pesticide applying cavity; the hydrogel shell covers the inner shell, and the hydrogel shell is provided with a medicine applying opening, a camera shooting opening and a lighting opening. According to the medical magnetic drive capsule endoscope, when the medical magnetic drive capsule endoscope advances in the intestinal tract of a patient, friction between the hydrogel shell and the intestinal wall is small, the intestinal wall is not prone to being damaged by friction, safety and comfort are improved, the advancing speed of the medical magnetic drive capsule endoscope can be increased, and examination efficiency is improved.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The present invention discloses a microgel based on acryloyl gelatin, a preparation method and an application thereof. A microfluidic method is used in combination with an online photopolymerization reaction to prepare an acryloyl gelatin microgel in high throughput, and the application thereof in the encapsulation of bioactive substances. First, acryloyl gelatin microdroplets are prepared in high throughput using droplet microfluidics technology, and then a visible light source matched with a photoinitiator is placed above the microfluidics pipeline to achieve online continuous production of GelA microdroplets and solidify to form microgel particles. For online encapsulation of substances, it is only necessary to pre-mix the active substances with the aqueous phase. The present invention combines the advantages of droplet microfluidics technology for high throughput production of droplets of uniform size, and also has the advantages of GelA's low viscosity, high photopolymerization efficiency and good biocompatibility. It can be used for high-efficiency and high-quality production of biocompatible microgels. The preparation process is also biocompatible and can meet the needs of online encapsulation of biomolecules and cells.

The invention belongs to the technical field of electrochemical detection, and relates to a composite material, an electrochemical sensor, a preparation method and application. The invention provides a multiwalled carbon nanotube / polyvinyl alcohol / phosphotungstic acid composite material. The multiwalled carbon nanotube / polyvinyl alcohol / phosphotungstic acid composite material is composed of carboxylated multiwalled carbon nanotubes, polyvinyl alcohol and phosphotungstic acid. According to the composite material, phosphotungstic acid is introduced and can be complexed with polyvinyl alcohol through hydrogen-bond interaction to form a stable hydrogel framework, so that the important problems that a multi-walled carbon nanotube / polyvinyl alcohol composite material is poor in film-forming adhesion, unstable in sensing characteristic and the like are solved.

This application relates to the field of biomedical technology, and in particular to the application of N-acetylneuraminic acid in the preparation of drugs for treating methamphetamine addiction. This application is the first to discover the key role of N-acetylneuraminic acid (Neu5Ac) in the treatment of methamphetamine addiction, which can significantly reduce the CPP score in methamphetamine-addicted mice, demonstrating a good therapeutic effect on methamphetamine addiction. Furthermore, Neu5Ac can be synthesized endogenously, exhibiting advantages such as good biocompatibility and low toxicity.

The invention relates to the technical field of separation and extraction of natural products, in particular to a method for supercritical separation and extraction of astaxanthin, which comprises the following steps: (1) weighing raw material components in parts by weight; (2) mixing a biomass raw material rich in astaxanthin with the functionalized deep-eutectic solvent, and performing physical field enhanced extraction to obtain an extracting solution; (3) filtering the extracting solution through a vibrating membrane, and purifying to obtain a trapped fluid containing astaxanthin; and (4) carrying out supercritical CO2 back extraction on the trapped fluid, separating to obtain an astaxanthin product, and recovering the functional eutectic solvent. According to the method, continuous membrane separation and purification under the eutectic solvent system are realized, the purity of astaxanthin and the proportion of all-trans astaxanthin are maintained while the extraction rate of astaxanthin is increased, the solvent can be recycled after being recovered, and the production cost and waste liquid discharge are greatly reduced. All the raw materials are nontoxic and harmless, no organic solvent is used in the technological process, and good application prospects are achieved.

The application provides a stimulation system, comprising: a stimulation part, comprising a first stimulation electrode and a first control module connected with the first stimulation electrode, the first control module comprising a first coil; a first regulation part, comprising a first regulation unit, the first regulation unit comprising a first regulation coil; wherein the stimulation part is configured to be implanted in a to-be-stimulated part of a to-be-tested object, the first regulation part is configured to be placed outside the to-be-tested object, the first regulation part outputs energy to the first control module by coupling the first regulation coil with the first coil, and controls the stimulation degree of the first stimulation electrode through the first control module. In the application, the stimulation part is configured to be implanted in the to-be-stimulated part of the to-be-tested object, and the first regulation part is configured to be placed outside the to-be-tested object, that is, a distributed arrangement mode is adopted. Based on the setting, the biological compatibility, battery safety, packaging tightness and overall reliability of the first regulation part are reduced, the production cost of the stimulation system can be significantly reduced, and the clinical promotion is facilitated.

The invention relates to the field of biodegradable materials, in particular to a manufacturing process of a degradable material for syringe production, and aims to solve the problem that the medical safety of syringes is not high due to poor antibacterial property and degradability of existing syringe production materials. According to the manufacturing process, the special injector material which has excellent antibacterial performance and can be quickly degraded in the natural environment is successfully prepared by taking the antibacterial degradable resin as a main raw material, so that the problems of cross infection and medical waste treatment which are easily caused by a traditional injector material are solved, and the concepts of environmental protection and sustainable development are met; the preparation method has wide application prospects and market value, and the preparation process is scientific, reasonable, simple, easy to implement and suitable for large-scale industrial production.

The invention provides a preparation method and application of a paper-based molecularly imprinted sensor capable of visually and simultaneously detecting two subtype influenza A viruses. In the invention, an MOF (Cu) paper-based material which is low in cost, easy to obtain and convenient to carry is used as a carrier, viruses H5N1 and H7N9 are used as templates, and imprinting is carried out on the surface of the carrier to obtain the molecularly imprinted polymer (MIPs). Wherein the MOF (Cu) not only serves as a colorimetric signal output element, but also plays a metal coordination role between Cu < 2 + > in the MOF (Cu) and coat protein of the virus, so that the virus can be effectively fixed on the surface of the paper-based MOF (Cu), surface imprinting of the virus on the paper-based MOF (Cu) is facilitated, and the specific recognition capability is improved. Due to the fact that the number of imprint cavities blocked by the MIPs after the MIPs are combined with target objects with different concentrations is different, the oxidation degrees of TMB are different, visual detection of the two viruses is achieved, and high-sensitivity quantitative detection can also be conducted through an ultraviolet and visible spectrophotometer. The sensor prepared by the invention is a universal virus sensor, and the paper-based sensor suitable for visually detecting other target objects can be prepared by selecting other target objects as template molecules for imprinting.

The invention provides an aqueous zinc ion battery electrolyte as well as a preparation method and application thereof, and relates to the technical field of electrolytes. The aqueous zinc ion battery electrolyte comprises zinc salt, O-phosphoethanolamine and water. O-phosphoethanolamine is added into the electrolyte, and O-phosphoethanolamine molecules not only can be preferentially adsorbed to the surface of a zinc negative electrode, but also can be subjected to an electrochemical decomposition reaction to form an organic-inorganic hybrid interface protection layer, so that direct contact between water molecules and the zinc negative electrode is prevented, and generation of negative electrode interface side reaction and growth of zinc dendrites are inhibited; the stability of a negative electrode interface is enhanced.