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Bio-magnesium alloy with anti-bacterial function and manufacturing method thereof

A magnesium alloy and biological technology, applied in the field of biological magnesium alloy design and manufacture, can solve the problems of high local concentration, bacterial infection around the implant, and cytotoxicity of surrounding tissue, etc. Specific surface area, the effect of accelerating the degradation rate

Inactive Publication Date: 2018-03-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, existing research is limited to nano-TiO 2 Used as a surface coating or coating additive in bio-magnesium alloys, the surface coating can only make the bio-magnesium alloy have antibacterial effect at the initial stage of implantation, but after the coating breaks and falls off, bacterial infection is still prone to occur around the implant
Moreover, the higher content of TiO in the surface coating 2 May accumulate at the site of implantation resulting in excessive local concentrations, which can be toxic to surrounding tissue cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.5g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.5g nano-TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. Nano-TiO was prepared by SLM technology at a laser power of 90W, a scanning speed of 300mm / min, a spot diameter of 90μm, a scanning distance of 0.08mm, and a powder coating thickness of 0.1mm. 2 / AZ91 magnesium alloy.

[0026] The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial ...

Embodiment 2

[0028] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.3g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.7g nano TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. At 90W laser power, 300mm / min scanning speed, 0.5mm spot diameter, 0.08mm scanning distance, and 0.1mm powder coating thickness, nano-TiO was prepared by SLM technology. 2 / AZ91 magnesium alloy.

[0029]The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial concentration of AZ91 ma...

Embodiment 3

[0031] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.7g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.3g nano TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. Nano-TiO was prepared by SLM technology at a laser power of 90W, a scanning speed of 300mm / min, a spot diameter of 90μm, a scanning distance of 0.08mm, and a powder coating thickness of 0.1mm. 2 / AZ91 magnesium alloy.

[0032] The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial ...

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Abstract

The invention relates to a bio-magnesium alloy with an anti-bacterial function and a method for manufacturing the bio-magnesium alloy by utilizing the laser selective smelting technology. The bio-magnesium alloy with the anti-bacterial function consists of a bio-magnesium alloy substrate and nanometer TiO2 distributed in the bio-magnesium alloy substrate; and in the bio-magnesium alloy with the anti-bacterial function, the mass percentage of the nanometer TiO2 is 3-7%. The manufacturing method comprises the steps that nanometer TiO2 powder and bio-magnesium alloy powder are prepared accordingto a designed ratio; the prepared powder is placed in a ball mill; in a protective atmosphere, mixed powder is obtained through high-speed ball milling; and then in the protective atmosphere, the bio-magnesium alloy with the anti-bacterial function is manufactured through laser selective smelting. The bio-magnesium alloy manufactured with the method has excellent anti-bacterial performance and cyto-compatibility, improved mechanical performance and a proper degradation rate; and the bio-magnesium alloy is advantaged compared with a current material when serving as an implant material.

Description

technical field [0001] The invention relates to a bio-magnesium alloy with antibacterial function and a method for preparing the bio-magnesium alloy by using laser selective melting (SLM) technology, which belongs to the field of bio-magnesium alloy design and manufacture. Background technique [0002] In recent years, biomagnesium alloys have become a new generation of medical implant materials due to their good biocompatibility, mechanical properties and biodegradable properties. As a metal material, the fracture toughness of biomagnesium alloy is higher than that of bioceramic materials, and its elastic modulus and compressive yield strength are closer to human bone than other metal implant materials, which can effectively alleviate the damage caused by traditional metal implant materials. The stress shielding effect plays an important role in tissue repair and fracture healing. Moreover, bio-magnesium alloys are easy to corrode in the internal environment, so as to achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/02C22C32/00C22C1/05B22F9/04B22F3/105B33Y10/00B33Y80/00A61L27/04A61L27/50
CPCA61L27/047A61L27/50C22C1/05C22C23/02C22C32/0036B22F9/04B33Y10/00B33Y80/00A61L2430/02B22F2009/043B22F2998/10B22F10/00B22F10/28B22F10/36B22F10/32Y02P10/25
Inventor 帅词俊高成德
Owner CENT SOUTH UNIV
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