Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof

A technology of nano antibacterial agent and zinc oxide, applied in the field of copper doped zinc oxide quantum dot nano antibacterial agent and its preparation, can solve the problem of no antibacterial effect found, and achieve the effect of good biocompatibility

Active Publication Date: 2020-01-14
GMY LIGHTING TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, studies have also shown that the antibacterial activity of quantum dots is related to their morphology. ZnO quantum dots in aqueous solution and ZnO quantum dots suspended in polyvinylpyrrolidone gel are effective against Listeri

Method used

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  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof
  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof
  • Copper-doped zinc oxide quantum dot nano antibacterial agent and preparation method thereof

Examples

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Example Embodiment

[0049] A preparation method of Cu-doped ZnO quantum dot nano antibacterial agent includes the following steps:

[0050] Weigh 0.5-2.0g of the zinc source and disperse the copper source with the molar ratio of zinc in the zinc source to copper in the copper source of 1:0.003-0.01 in 80-120 mL of organic solvent, and stir it evenly , Pour into a three-necked flask, heat in a water bath at 60-90℃, keep the temperature for 0.5-2h until the solution is clear and transparent, continue to stir at 20-30℃ and wait for use to obtain a zinc and copper mixed precursor solution; add 0.15-1g The alkali source is added to 80-120mL organic solvent, and after magnetic stirring at 20-30°C for 20-40 minutes, the resulting alkali solution is added dropwise to the zinc and copper mixed precursor solution prepared in the previous stage. After the mixture is uniform, 20-30°C magnetically Stir for 20-40min. After the reaction, add 50-100mL of precipitant until the solution becomes milky white. Stir magn...

Example Embodiment

[0055] Example 1

[0056] A preparation method of copper-doped zinc oxide quantum dot nano antibacterial agent includes the following steps:

[0057] Weigh 0.768g zinc acetate dihydrate and 4.89mg copper acetate monohydrate and disperse them in 100mL absolute ethanol, stir well, pour into a three-necked flask, heat in a water bath at 80°C for 0.5h until the solution is clear and transparent, and at 20°C Stir continuously and set aside to obtain a mixed precursor solution of zinc and copper; add 0.15g of lithium hydroxide to 100mL of ethanol solution, and after magnetic stirring at 20°C for 30 minutes, add the resulting alkaline solution dropwise to the zinc and copper mixture prepared in the previous stage In the precursor solution, after mixing uniformly, magnetically stir at 20°C for 30min, add 80mL of deionized water until the solution becomes milky white after the reaction, stir magnetically at 20°C for 10min, stand, clean, and centrifuge at 6000rpm for 30min to obtain copper (...

Example Embodiment

[0058] Example 2

[0059] A preparation method of copper-doped zinc oxide quantum dot nano antibacterial agent includes the following steps:

[0060] Weigh 1.1g zinc nitrate hexahydrate and 6.98mg copper nitrate trihydrate and disperse in 100mL absolute ethanol, stir well, pour into a three-necked flask, heat in a water bath at 80℃ for 1h until the solution is clear and transparent, continue at 23℃ Stir and set aside to obtain a zinc and copper mixed precursor solution; add 0.3 g of lithium hydroxide to 100 mL of ethanol solution, and after magnetic stirring at 23°C for 30 minutes, add the resulting alkaline solution dropwise to the zinc and copper mixed precursor prepared in the previous stage In the body solution, after mixing uniformly, magnetically stir at 23°C for 30min. After the reaction, add 100mL of deionized water until the solution becomes milky white. Stir magnetically at 23°C for 10min, stand, clean, and centrifuge at 8000rpm for 18min to obtain copper (Cu) Nano antib...

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Abstract

The invention relates to a copper-doped zinc oxide quantum dot nano antibacterial agent and a preparation method thereof. A chemical formula of the copper-doped zinc oxide quantum dot nano antibacterial agent is Zn<1-x>OCu<x> (x = 0.003-0.01). The preparation method comprises the following steps: weighing a zinc source and a copper source and performing dispersing in an organic solvent, performingstirring and heating in a water bath until a solution is clear and transparent, and performing stirring again to obtain a zinc and copper mixed precursor solution; adding an alkali source into an organic solvent, and performing stirring to obtain an alkali solution; dropwise adding the alkali solution into the zinc and copper mixed precursor solution, and performing stirring to obtain a mixed solution; and adding a precipitant into the mixed solution, performing stirring and then performing standing, washing and centrifuging to obtain the copper-doped zinc oxide quantum dot nano antibacterialagent. A size of the Cu-doped ZnO quantum dot is mainly distributed in 4-8 nm. A minimum bacteriostatic concentration of the nano antibacterial agent against Escherichia coli can reach 2.7 mg/mL, anda bacteriostatic rate against Escherichia coli can reach 81.79%.

Description

technical field [0001] The invention belongs to the technical field of novel antibacterial agents, and relates to a copper (Cu) doped zinc oxide quantum dot (ZnO QDs) nano antibacterial agent and a preparation method thereof. Background technique [0002] With the development of society and the improvement of material living standards, people have higher and higher requirements for living environment, but the increase of microbial resistance to drug treatment, control and eliminate the growth and reproduction of harmful bacteria to ensure human health and safety issues It is getting more and more attention from all walks of life. In the decades of human use of antibiotics to treat infectious diseases, a large number of multidrug-resistant strains have emerged. In order to improve the efficacy of antibiotics, powerful new antibiotics or compound antibacterial agents have been developed on the one hand, but the functions of new drugs are inevitably affected by pathogenic bacte...

Claims

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Application Information

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IPC IPC(8): A01N59/20A01N59/16A01P1/00B82Y30/00B82Y40/00
CPCA01N59/16A01N59/20B82Y30/00B82Y40/00
Inventor 刘俊莉王宇涵刘辉洪燕南李军奇蔡永华廖辉
Owner GMY LIGHTING TECH CO LTD
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