80 results about "Microbial resistance" patented technology

Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and de endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.

The invention provides a preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan and belongs to the technical field of novel biomaterials. The preparation method solves problems of high cost, complex steps, low yield and low performance of obtained quaterisation chitosan products which can hardly meet requirements of people in an existing preparation method of chitosan quaternary ammonium salt. The preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan comprises the following steps: A. soaking the chitosan; B. heterogeneous reaction; and C. refining. The preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan is achieved by less solvent and high-stability raw materials. The 2-hydroxypropyltrimethyl ammonium chloride chitosan prepared by the method has high yield, higher purity and better quality indexes such as moisture retention, hygroscopicity and microbial resistance.

Antimicrobial compositions containing two or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. In one embodiment, two or more antiviral agents are covalently coupled to the polymer. Suitable antiviral agents include, but are not limited to, sialic acid, zanamivir, oseltamivir, amantadine, rimantadine, and combinations thereof. The polymer is preferably a water-soluble, biocompatible polymer. Suitable polymers include, but are not limited to, poly(isobutylene-alt-maleic anhydride) (PIBMA), poly(aspartic acid), poly(l-glutamic acid), polylysine, poly(acrylic acid), plyaginic acid, chitosan, carboxymethyl cellulose, carboxymethyl dextran, polyethyleneimine, and blends and copolymers thereof. In another embodiment, the compositions contain a physical mixture of polymer containing one antiviral agent and polymer containing a second antiviral agent. The compositions can be formulated for enteral or parenteral administration. Suitable oral/intranasal dosage forms include, but are not limited to, tablets, capsules, solutions, suspensions, emulsions, syrups, and lozenges. Suitable dosage forms for parenteral administration include, but are not limited to, solutions, suspensions, and emulsions. The compositions described herein are effective at treating a variety of infections, including viral infections such as influenza, while inhibiting or preventing the development of microbial resistance.

Novel compositions and methods of reducing microbial resistance to antimicrobial agents and treating infections are disclosed. In particular, compositions and methods of inhibiting efflux pump activity, treating infection and methods of enhancing antimicrobial activity of antimicrobial agents are provided.

Novel compositions and methods of reducing microbial resistance to antimicrobial agents and treating infections are disclosed. In particular, compositions and methods of inhibiting efflux pump activity, treating infection and methods of enhancing antimicrobial activity of antimicrobial agents are provided.

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

The invention relates to a modified straw wood charcoal adsorbent which is prepared from the following raw materials in parts by weight: 110-120 parts of straw wood charcoal, 8-10 parts of zeolite powder, 7-9 parts of medical stone powder, 7-9 parts of acrylamide, 6-9 parts of kieselguhr, 16-20 parts of citric acid, 3-4 parts of EDTA (ethylene diamine tetraacetic acid), 4-6 parts of sodium tripolyphosphate, 4-5 parts of modified kieselguhr and right amount of water. The zeolite, medical stone, kieselguhr and other rock powders used for modification can enhance the adsorptivity, implement microbial resistance, deodorization, moisture absorption, mold prevention and desulfurization, and catalyze the decomposition of organic substances; the acrylamide can flocculate pollutants in water; by using the straw wood charcoal as the substrate, the adsorbent has the advantages of developed pores, high adsorption capacity and low cost, and is suitable for industrial production; and the adsorbent is suitable for daily air and water purification, and also suitable for treating industrial wastewater and waste gas.

The invention discloses a micro-nano fiber yarn spinning device and a spinning process thereof. The micro-nano fiber yarn spinning device comprises a spinning jet, a yarn feeding system, a fiber polymerization mechanism and a twisting mechanism, wherein the spinning jet is composed of a hot air pipe, a polymer melt pipe and a cold air pipe, the yarn feeding system is composed of cheese yarns, an unwinding roller and a yarn guide rod, the fiber polymerization mechanism is composed of an upper roller and a lower roller which are mutually connected in a meshed mode, a plurality of micro-pores are formed in the bottom of the groove of the lower roller, and an irregular air pipe is further arranged inside the lower roller. The micro-nano fiber yarn spinning device is reasonable in structure and process design, convenient to operate actually and capable of spinning micro-nano fiber sprayed out of the melting-spraying spinning jet into micro-nano fiber core spun yarns, the micro-nano fiber wraps the surfaces of core yarns, and the attachment rate and the working efficiency are high, so that produced yarns have the functions of microbial resistance, heat insulation, heat preservation, filtering and adsorption, sound absorption and the like.

Provided are additives of formula I for use in hydrocarbonaceous compositions, such as petroleum or liquid fuels: (I) wherein R¹, R², R³, R⁴, and R⁵ are as defined herein. The additives improve the corrosion resistance of the compositions and, when the composition is biodiesel, also improve microbial resistance. The additives further enhance the antimicrobial efficacy of any added biocides contained in such compositions.

The invention discloses a water-in-water antimicrobial multicolor paint which is prepared by mixing a base paint, a protective adhesive and a varnish. The base paint is prepared from 50-150 parts of water-based elastic polyurethane emulsion, 20-60 parts of kaolin, 10-30 parts of titanium white, 0-30 parts of environment-friendly inorganic pigment, 5-10 parts of antimicrobial agent, 1-10 parts of defoaming agent, 1-10 parts of film forming aid and 100-300 parts of water. The protective adhesive is prepared from 30-80 parts of acrylate emulsion, 1-10 parts of preservative and 100-300 parts of water. The varnish is prepared from 20-100 parts of water-based pure acrylic elastic emulsion, 10-30 parts of waterproofing agent, 0.5-5 parts of thickener and 30-80 parts of water. The invention also discloses a preparation method of the multicolor paint. The multicolor paint has the characteristics of excellent mechanical properties, microbial resistance, water resistance, pollution resistance, high washability and scrub resistance; and the colors can be matched freely, thereby implementing perfect picture drawing.

The present invention relates to a new and inventive composition for implant cleaning and/or debridement of hard surfaces in the oral cavity, which comprises optimally activated nanoparticles of TiO₂, having a mean particle diameter (D₅₀) of about 10-100 nm at a concentration between 0.5-500 g/L, and H₂O₂, at a concentration of at the most 7.5% by volume, said composition being antibacterial, without causing microbial resistance, and anti-inflammatory, and wherein said composition further comprises solid microparticles, having a mean particle diameter (D₅₀) of about 100-200 μm at a concentration between 0.5-300 g/L, for improved mechanical debridement and/or cleaning of rough surfaces in the oral cavity and/or on an implant.

The invention discloses single-component heavy-duty corrosion-resistant polyurea for a buried pipeline. The polyurea is prepared from the following components in parts by weight: 25-70 parts of isocyanate, 50-80 parts of polyalcohol, 5-30 parts of hindered amine compound, 10-30 parts of solvent, 5-40 parts of filler, 0.5-2 parts of defoamer, 0.5-2 parts of catalyst, 1-3 parts of pigment, 5-15 parts of latent curing agent, 5-10 parts of water absorbent and 1-3 parts of retarder, wherein the isocyanate is aliphatic isocyanate and/or aromatic isocyanate. The hindered amine compound is added into the single-component heavy-duty corrosion-resistant polyurea, so that a urea group is introduced in the component to increase the polarity of the component, thereby increasing the attraction of a hard segment of the single-component heavy-duty corrosion-resistant polyurea. The single-component heavy-duty corrosion-resistant polyurea is more compact, and the oil resistance, the medium resistance and the microbial resistance of the single-component heavy-duty corrosion-resistant polyurea are improved. The single-component heavy corrosion-resistant polyurea disclosed by the invention can be used for repairing a heavy-duty corrosion-resistant coating for the buried pipeline.

The invention relates to an environment-friendly preservative film which comprises a substrate, a high-temperature-resistant agent, a toughener, a preservative, an antioxidant, an antiseptic and a coating agent, wherein the substrate is polyethylene plastic; the high-temperature-resistant agent is polyimide; the toughener is polyvinyl acetate; the preservative is deacetylated chitin; the antioxidant is tert-butylhydroquinone; the antiseptic is propyl p-hydroxybenzoate; and the coating agent is pentalyn. Multiple additives are added into the polyethylene plastic, so that the environment-friendly preservative film formed by mixing has the advantages of high-temperature resistance, favorable tear resistance, favorable preservative effect, long expiration date and microbial resistance. The product is prepared from nontoxic pollution-free materials, and thus, is environment-friendly, nontoxic and harmless.

Disclosed are various genes encoding proteins that are shown to play a role, direct or indirect, in microbial resistance of an organism in a biofilm and homologs thereof. Also disclosed are methods of identifying a compound that modulates microbial resistance of an organism in a biofilm, and methods of identifying genes that encode proteins that play a role, direct or indirect, in biofilm resistance.

The invention relates to a medical stone powder filler for cables. The medical stone powder filler is prepared from the following raw materials in parts by weight: 2-3 parts of vinyl acetate resin emulsions, 1-2 parts of 3-aminopropyl triethoxysilane, 0.2-0.3 part of tallow seed oil, 2-3 parts of barium oxide, 2-3 parts of N-phenyl-2-naphthylamine, 0.2-0.3 part of sodium percarbonate, 0.4-0.5 parts of PVC (Polyvinyl Chloride) paste resin, 0.2-0.3 part of triaryl phosphate, 0.3-0.5 parts of distearyl thiodipropionate, 75-80 parts of medical stone powder, a right amount of water, a right amount of 4%-6% hydrochloric acid and 10-15 parts of auxiliary agents. Medical stone powder is used in the filler disclosed by the invention; according to the filler, good surface hydrophobicity is achieved by carrying out organic modification on the surface, good reinforcing property is achieved due to the increase of compatibility with a cable material, and the toughness and tensile strength of the cable material can be enhanced; the cable material has the characteristics of flame resistance, acid and alkali resistance, microbial resistance and abrasion resistance due to the addition of the PVC paste resin; and the auxiliary agents can enhance the dispersity of the filler.

An insulation product that contains a Kraft paper facing treated with a combination of antimicrobial agents that imparts improved microbial resistance to the Kraft paper is provided. A preferred anti-microbial composition includes (1-[[2-(2,4-dichloropheyl)-4-propyl-1,3-diololan-2-yl]-methyl]-1H-1,2,4-triazole, α-(2-(4-chlorphenyl)ethyl)-α-(1-1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol, and alkyl dimethylbenzyl ammonium saccharinate. The anti-microbial agents may each be present in the anti-microbial composition in an amount of from 50 to 1000 ppm. A biocide such as 2-(4-thiazolyl)benzimidazole may be added to the anti-microbial composition to impart additional microbial resistance. The Kraft paper may be adhered to the insulation by anti-microbially treated asphalt. The anti-microbial agent may be added to the asphalt in an amount of from 200-3000 ppm prior to applying the asphalt to the Kraft paper. In at least one exemplary embodiment, 2-n-octyl-4-isothiazolin-3-one is added to the asphalt. The insulation product formed is substantially free of bacteria, fungi, and molds.

A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.

The invention relates to a cephalosporin compound and a preparation method thereof. Methoxyl cephalosporin is a cephalosporin derivative where alpha-methoxyl is introduced to position 7. As the methoxyl has the steric hindrance effect to prevent enzyme molecules from approaching beta-lactam ring, so that the stability of the medicine to beta-lactamase is increased, and the activity to anaerobion is improved. In recent years, antibiotic resistive phenomena often occur to affect use of some antibiotics in main categories, so that development of the antibiotic market is directly restricted. Therefore, research of novel cephalosporin compounds is necessary. The cephalosporin compound has the structural formula (I). The invention further relates to the preparation method of the cephalosporin compound and a preparation method of intermediates in the preparation process. The invention provides the cephalosporin compound and the preparation method thereof as well as a novel cephalosporin compound and the preparation method thereof. The cephalosporin compound can be used as an ideal substitutive pharmaceutical compound for conventional antibiotics and antibiotics with microbial resistance.

The invention relates to a microbial resistance test device and a method for plasma sterilization verification. The technical problem to be solved is to provide the microbial resistance test device and the method for the plasma sterilization verification, the invention aims at carrying out the research of the related sterilization resistance of standard microbial strains which are used after the hydrogen peroxide plasma sterilization test through the device and the method, thereby comparing and selecting the strain with the strongest resistance as the standard test strain. The technical proposal for solving the problems is as follows: a resistance detection device is arranged in an experimental tank room, a temperature sensor II is matched therewith, a neutralizer filling device and a sterilization media filling device are connected at the outside of the experimental tank room, the neutralizer filling device is communicated with the resistance detection device through a connecting guide tube I via a sealing interface on the wall of the experimental tank room, and the sterilization media filling device is connected with an atomizing nozzle which is arranged above the tank wall of a vacuum tank through a connecting guide tube II via a micro-electromagnetic valve. The microbial resistance test device and the method can be used for the hydrogen peroxide plasma sterilization test.

The invention discloses a water-based fluid composition for machining; the fluid composition includes a mixture of the following substances: a) water, b) a water insoluble organic lubricant, c) a surfactant selected from the group consisting of non-ionic surfactants, anionic surfactants with less than or equal to 12 carbon atoms and cationic surfactants and mixtures thereof, and d) a water-soluble polyquaternary cation biocide. The invention also provides a machining method including a step of applying a water-based fluid for machining to a contact surface between a tool and a workpiece. The water-based fluid for machining is different from a synthetic water-based fluid composition for machining, the fluid is called as a soluble oil and semisynthesis water-based fluid for machining in the field, belongs to an emulsion, not only maintains the stability of the emulsion, but also can overcome the known characteristic that the water-based fluid composition for machining has no anti-microbial resistance, and has the advantages of resistance to microbial growth and invasion and improvement of the anti-microbial life.