13 results about "Microbial resistance" patented technology

A process for manufacturing the composition coating may include selecting a wood or masonry material substrate and utilizing a sol-gel comprising a silane or silane derivative and metal oxide precursor to coat the substrate. The process may utilize an all solution process or controlled environment for manufacturing a composition coating that prevent wetting and / or staining of a substrate. The composition coatings for treating wood or masonry materials improves weather-resistance, microbial resistance, stain-resistance and fungal-resistance of the materials. The reduced permeability of the resulting masonry materials can also delay or inhibit degradation caused by permeation of ions such as chlorides and sulfates. In addition, a stain comprising the composite solution and pigments may impart additional property to wood or masonry materials whilst retaining or improving the original appearance, particularly for the visibility and contrast of the wood grain as seen after the application of the coating.

Provided herein are methods of targeted genomic sequencing requiring only a single amplification step. The Single Amplification Sequencing (SAS) assay provided herein amplies and sequences targeted genomic regions at reduced time and cost. The assay provides robust coverage and accurate drug resistance profiles for multiple first- and second-line Tuberculosis drugs, showcasing its clinical utility for rapid antimicrobial resistance (AMR) detection. SAS significantly simplifies targeted Next Generation Sequencing (tNGS) workflows and holds significant promise for revolutionizing precision diagnostics across a wide array of clinical and research settings.

The application discloses application of Enterobacter kobei in controlling and resisting evolution of soil bacteria antibiotic resistance. Enterobacter kobei LB1 is preserved in the China General Microbiological Culture Collection Center on May 15, 2026, and has a preservation number of CGMCC No. 38684 and a preservation address of No. 1, Xibaixili, Chaoyang District, Beijing, China Institute of Microbiology. Enterobacter kobei LB1 and extracellular metabolites have the ability of controlling and resisting evolution of soil bacteria antibiotic resistance. The application verifies the inhibiting effect of the resistance mutant strain of the control agent through a soil microcosm experiment, realizes effective intervention on the evolution of soil microbial resistance, and has the advantages of green ecology, safety, high efficiency, long-term control and the like, and provides a new technical way for environmental antibiotic resistance pollution treatment.

Provided herein are combinations of one or more hydrolases and one or more antimicrobial agents, as well as pharmaceutical compositions or kits comprising the same. Also provided are methods of treating microbial infections using a therapeutically effective amount of the combination, pharmaceutical composition, or kit. The combination is safer and more economical, can be clinically re-sensitive to a variety of bacteria at a lower dose, and avoids antimicrobial resistance, thereby prolonging the life of the drug.

The invention discloses a synergistic method for garden cleaning, soil improvement and attractant application in green prevention and control of waxberry diseases and insect pests, and relates to the field of fruit tree cultivation and disease and insect pest prevention and control. The method comprises the following steps: step 1, double-period garden cleaning; step 2, soil micro-ecology reconstruction; step 3, inducing and repelling synergistic treatment; 4, intelligently monitoring the trapping device; and 5, carrying out synergistic interaction treatment. According to the method, a pest breeding chain is blocked through double-period garden cleaning, the cardinal number of pests is reduced, soil microorganism resistance is enhanced through soil improvement, soil organic matter is increased, the incidence rate of shallot disease is reduced, the effect of accurate intervention is achieved through trapping and repelling cooperative treatment, imagoes are trapped and killed, oviposition is blocked, and through three-stage cooperation of garden cleaning management, soil improvement and attractant application, the yield is increased. Waste resource utilization, plant source repellents, intelligent monitoring and ecological regulation and control are innovatively combined, the defect that the control effect of a single technology is unstable is overcome, and waxberry quality improvement and orchard ecological environment sustainable maintenance are achieved.

This invention belongs to the field of organoid culture technology, specifically relating to a highly efficient organoid anticontamination reagent. This highly efficient organoid anticontamination reagent is composed of Primocin, amphotericin B, and Y-27632. In the organoid culture medium system, the final concentration of Primocin is 20-70 μg / mL, the final concentration of amphotericin B is 0.1-1 μg / mL, and the final concentration of Y-27632 is 5-20 μM. The highly efficient organoid anticontamination reagent provided by this invention exhibits dual high-efficiency inhibition against both bacteria and fungi, has a broad anticontamination spectrum, and is not prone to inducing microbial resistance. Simultaneously, it can reduce cytotoxicity, and long-term use does not alter the expression of organoid-specific markers, thus maintaining differentiation function.

The invention relates to the determination of resistances of microorganisms which produce β-lactamases, in particular “extended spectrum β-lactamases” (ESBL). The invention provides a method whereby the microbial resistance can be measured very simply and quickly by means of the catalytic effect of the microbially produced β-lactamases on β-lactam antibiotics, which consists in a hydrolytic cleavage of the β-lactam ring. The method determines the resistance of the bacteria a few hours after a suitable substrate, either a β-lactam antibiotic or a customized β-lactam derivative, has been added to a suspension of the microbes, by direct mass spectrometric measurement of the substrate breakdown caused by the β-lactamases.

A bacterial antimicrobial drug resistance prediction method and system is characterized in that a hierarchical configuration unit divides drug resistance prediction elements into a patient risk hierarchy, a microbial feature hierarchy, a regional epidemic hierarchy, a clinical rule hierarchy and a drug characteristic hierarchy, and each hierarchy comprises an initial attribute value and a hierarchy exclusive dynamic rule set; the data processing unit obtains real-time clinical data, each hierarchy independently processes the data through a hierarchy exclusive dynamic rule set of the hierarchy, and an initial attribute value is converted into a target attribute value; a decision superposition unit superposes the target attribute values of the hierarchies according to the weight priorities of the hierarchies to generate a bacterial antimicrobial drug resistance prediction result and an antibacterial drug recommendation scheme; and the report output unit outputs a visual report. Through hierarchical design and rule monitoring separation architecture, accurate, explainable and high-adaptability bacterial antimicrobial drug resistance prediction is realized, meanwhile, dependence on high-computing-power equipment is reduced, and the method is adaptive to use scenes of basic medical institutions.

Discloses herein is a packaging article (310, 311, 312, 313) for packaging and transportation of the glass and glass articles. The packaging article (310, 311, 312, 313) comprises plurality of modular units in multiple dimensions adapted to form a packaging unit and each modular unit comprises a corrugated sheet (200) provided with at least one kind of natural fibre for stiffness. The corrugated sheet (200) includes fluted layer; said natural fibre layer being incorporated in the corrugated sheet as a composite. This corrugated sheet is further configured to have an environmental protection layer that can be moisture resistant, termite / mite resistant, anti-microbial resistance or dust resistant. The disclosed solution is 100% sustainable packaging and this could be achieved using cardboard composite box which is completely circular, re- usable, ease of use and maintenance.

This invention provides the production and application of an antimicrobial protein targeting Propionibacterium acnes. The invention provides the application of the antimicrobial protein in products for the prevention and treatment of acne or infections caused by Propionibacterium acnes or conditions related to Propionibacterium acnes. The antimicrobial protein comprises an amino acid sequence as shown in SEQ ID NO. 6, or an active fragment thereof, or analogues thereof, which inhibit the growth of Propionibacterium acnes. The antimicrobial protein of this invention can specifically and effectively kill Propionibacterium acnes without affecting the host and other common skin microorganisms, providing a safe and effective acne solution suitable for long-term use without causing skin microecological imbalance or the risk of microbial resistance.

The invention relates to the field of functional textile materials, and discloses a natural pearl fiber mesh fabric and a preparation method thereof. Natural pearl powder is adopted as a core functional raw material, natural antibacterial components, the contact cool feeling characteristic and bioactive factors contained in the pearl material are fully utilized, and permanent combination of functional components and a fiber matrix is achieved in the yarn spinning stage; hidden dangers such as heavy metal accumulation, toxic residue precipitation and microbial drug resistance induction are avoided, and the fabric is endowed with a self-maintaining functional characteristic through a copolymerization combination mechanism of pearl calcium carbonate crystals and fibers. A final product shows performance which is obviously superior to that of a chemical treatment scheme in the aspects of contact cool feeling response efficiency, broad-spectrum antibacterial durability, far infrared radiation stability and amino acid slow release capability, and meanwhile, the synergistic effect of natural functions is further amplified by combining with a three-dimensional mesh structure design; and durability and environmental friendliness are realized on the premise of ensuring zero chemical addition.

The present invention provides to an adhesive composition that that is cost-effective, renewable, biodegradable, and exhibits superior bonding strength, water resistance, microbial resistance, durability, and versatility. The adhesive is formulated to be easily applied and cured at ambient temperatures, without the need for mixing or specialized equipment. The unique combination of ingredients provides a strong and lasting bond on a variety of substrates, including metals, plastics, wood, and composites. The adhesive composition contains: a bio-based component; a base polymer; a zinc-containing compound; and a solvent that has low or is free from volatile organic compounds. The adhesive may further contain one or more additives.

A bacterial antimicrobial resistance prediction method and system, a hierarchical configuration unit divides resistance prediction elements into patient risk levels, microbial feature levels, regional prevalence levels, clinical rule levels and drug property levels, each level includes initial attribute values and level-specific dynamic rule sets; a data processing unit acquires real-time clinical data, each level independently processes data through its level-specific dynamic rule set, and converts initial attribute values into target attribute values; a decision superposition unit superimposes the target attribute values of each level according to the weight priority of each level to generate a bacterial antimicrobial resistance prediction result and an antibacterial drug recommendation scheme; a report output unit outputs a visual report. The present application realizes precise, interpretable and highly adaptive bacterial antimicrobial resistance prediction through hierarchical design and rule monitoring separation architecture, while reducing the dependence on high-performance equipment and adapting to the use scenarios of primary medical institutions.