8 results about "Microbial resistance" patented technology

A process for manufacturing the composition coating may include selecting a wood or masonry material substrate and utilizing a sol-gel comprising a silane or silane derivative and metal oxide precursor to coat the substrate. The process may utilize an all solution process or controlled environment for manufacturing a composition coating that prevent wetting and / or staining of a substrate. The composition coatings for treating wood or masonry materials improves weather-resistance, microbial resistance, stain-resistance and fungal-resistance of the materials. The reduced permeability of the resulting masonry materials can also delay or inhibit degradation caused by permeation of ions such as chlorides and sulfates. In addition, a stain comprising the composite solution and pigments may impart additional property to wood or masonry materials whilst retaining or improving the original appearance, particularly for the visibility and contrast of the wood grain as seen after the application of the coating.

Provided herein are methods of targeted genomic sequencing requiring only a single amplification step. The Single Amplification Sequencing (SAS) assay provided herein amplies and sequences targeted genomic regions at reduced time and cost. The assay provides robust coverage and accurate drug resistance profiles for multiple first- and second-line Tuberculosis drugs, showcasing its clinical utility for rapid antimicrobial resistance (AMR) detection. SAS significantly simplifies targeted Next Generation Sequencing (tNGS) workflows and holds significant promise for revolutionizing precision diagnostics across a wide array of clinical and research settings.

The application discloses application of Enterobacter kobei in controlling and resisting evolution of soil bacteria antibiotic resistance. Enterobacter kobei LB1 is preserved in the China General Microbiological Culture Collection Center on May 15, 2026, and has a preservation number of CGMCC No. 38684 and a preservation address of No. 1, Xibaixili, Chaoyang District, Beijing, China Institute of Microbiology. Enterobacter kobei LB1 and extracellular metabolites have the ability of controlling and resisting evolution of soil bacteria antibiotic resistance. The application verifies the inhibiting effect of the resistance mutant strain of the control agent through a soil microcosm experiment, realizes effective intervention on the evolution of soil microbial resistance, and has the advantages of green ecology, safety, high efficiency, long-term control and the like, and provides a new technical way for environmental antibiotic resistance pollution treatment.

This invention belongs to the field of organoid culture technology, specifically relating to a highly efficient organoid anticontamination reagent. This highly efficient organoid anticontamination reagent is composed of Primocin, amphotericin B, and Y-27632. In the organoid culture medium system, the final concentration of Primocin is 20-70 μg / mL, the final concentration of amphotericin B is 0.1-1 μg / mL, and the final concentration of Y-27632 is 5-20 μM. The highly efficient organoid anticontamination reagent provided by this invention exhibits dual high-efficiency inhibition against both bacteria and fungi, has a broad anticontamination spectrum, and is not prone to inducing microbial resistance. Simultaneously, it can reduce cytotoxicity, and long-term use does not alter the expression of organoid-specific markers, thus maintaining differentiation function.

A bacterial antimicrobial drug resistance prediction method and system is characterized in that a hierarchical configuration unit divides drug resistance prediction elements into a patient risk hierarchy, a microbial feature hierarchy, a regional epidemic hierarchy, a clinical rule hierarchy and a drug characteristic hierarchy, and each hierarchy comprises an initial attribute value and a hierarchy exclusive dynamic rule set; the data processing unit obtains real-time clinical data, each hierarchy independently processes the data through a hierarchy exclusive dynamic rule set of the hierarchy, and an initial attribute value is converted into a target attribute value; a decision superposition unit superposes the target attribute values of the hierarchies according to the weight priorities of the hierarchies to generate a bacterial antimicrobial drug resistance prediction result and an antibacterial drug recommendation scheme; and the report output unit outputs a visual report. Through hierarchical design and rule monitoring separation architecture, accurate, explainable and high-adaptability bacterial antimicrobial drug resistance prediction is realized, meanwhile, dependence on high-computing-power equipment is reduced, and the method is adaptive to use scenes of basic medical institutions.

Discloses herein is a packaging article (310, 311, 312, 313) for packaging and transportation of the glass and glass articles. The packaging article (310, 311, 312, 313) comprises plurality of modular units in multiple dimensions adapted to form a packaging unit and each modular unit comprises a corrugated sheet (200) provided with at least one kind of natural fibre for stiffness. The corrugated sheet (200) includes fluted layer; said natural fibre layer being incorporated in the corrugated sheet as a composite. This corrugated sheet is further configured to have an environmental protection layer that can be moisture resistant, termite / mite resistant, anti-microbial resistance or dust resistant. The disclosed solution is 100% sustainable packaging and this could be achieved using cardboard composite box which is completely circular, re- usable, ease of use and maintenance.

The present invention provides to an adhesive composition that that is cost-effective, renewable, biodegradable, and exhibits superior bonding strength, water resistance, microbial resistance, durability, and versatility. The adhesive is formulated to be easily applied and cured at ambient temperatures, without the need for mixing or specialized equipment. The unique combination of ingredients provides a strong and lasting bond on a variety of substrates, including metals, plastics, wood, and composites. The adhesive composition contains: a bio-based component; a base polymer; a zinc-containing compound; and a solvent that has low or is free from volatile organic compounds. The adhesive may further contain one or more additives.

A bacterial antimicrobial resistance prediction method and system, a hierarchical configuration unit divides resistance prediction elements into patient risk levels, microbial feature levels, regional prevalence levels, clinical rule levels and drug property levels, each level includes initial attribute values and level-specific dynamic rule sets; a data processing unit acquires real-time clinical data, each level independently processes data through its level-specific dynamic rule set, and converts initial attribute values into target attribute values; a decision superposition unit superimposes the target attribute values of each level according to the weight priority of each level to generate a bacterial antimicrobial resistance prediction result and an antibacterial drug recommendation scheme; a report output unit outputs a visual report. The present application realizes precise, interpretable and highly adaptive bacterial antimicrobial resistance prediction through hierarchical design and rule monitoring separation architecture, while reducing the dependence on high-performance equipment and adapting to the use scenarios of primary medical institutions.