64 results about "Hydroxypropyltrimethyl ammonium chloride chitosan" patented technology

The invention provides a preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan and belongs to the technical field of novel biomaterials. The preparation method solves problems of high cost, complex steps, low yield and low performance of obtained quaterisation chitosan products which can hardly meet requirements of people in an existing preparation method of chitosan quaternary ammonium salt. The preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan comprises the following steps: A. soaking the chitosan; B. heterogeneous reaction; and C. refining. The preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan is achieved by less solvent and high-stability raw materials. The 2-hydroxypropyltrimethyl ammonium chloride chitosan prepared by the method has high yield, higher purity and better quality indexes such as moisture retention, hygroscopicity and microbial resistance.

The invention discloses a preparing method and application of polyose quaternary ammonium salt in oceanography engineering technique domain, which comprises the following steps: modify for high and low molecular weight chitose with glycidyl trimethyl ammonium chloride; adopting different condition; preparing hydroxypropyl trimethyl amchlor chitose; proceeding simulation for the structure with infrared spectrum; analyzing for IR spectrogram; replacing with N upper; possessing oxidation resistance desiccating moisture keeping active; setting the active stronger than chitose quaternary ammonium salt. This invention can increase oxidation resistance and desiccating moisture keeping property of the chitose, which can be used as antioxidant and humectant for food and cosmetic product.

The invention provides an O-2`-Hydroxypropyltrimethyl ammonium chloride chitosan preparation method, which comprises the following steps: firstly, Beta-Chitin is reacted with modifying agent to synthesize O-2`-Hydroxypropyltrimethyl ammonium chloride Chitin; secondly, acetyl of C2 digit on O-2`-HTACCt sugar ring is divested through reaction to obtain O-2`-HTACCts. Quaternary ammonium salt derivatives displacement reaction positioning in the invention occurs on hydroxyl of Beta-Chitin sugar ring, Chitin and chitosan quaternary ammonium salt derivatives of the hydroxyl positioning displacement are obtained, thus the method is simple and reliable. The degree of substitution (DS) of the intermediate product O-2`-HTACCt is more easily adjusted. The deacetylating reaction conditions are mild, the chitosan trunk chain degradation reaction degree is reduced, therefore O-2`-HTACCts with the high deacetylation degree (DD) and the high degree of substitution (DS) are obtained.

The invention relates to a composition and a method for preparing modified calcium carbonate and belongs to the field of chemicals. The composition comprises the following components: a polymer, calcium chloride and carbonate, wherein the polymer is any one or more of cationic starch, cationic guar gum, chitosan hydrochloride and 2-hydroxypropyl trimethyl ammonium chloride chitosan; and the carbonate is any one or more of potassium carbonate, sodium carbonate, ammonium carbonate and ammonium bicarbonate. The preparation method comprises the following steps of: (1) preparing aqueous solution of the polymer; (2) adding the calcium chloride into the carbonate; (3) adding the aqueous solution of the polymer into a mixture obtained by the step (2); (4) obtaining calcium carbonate precipitate; and (5) washing and drying the calcium carbonate precipitate. The method has the advantages of simpleness, temperate reaction conditions, and capability of preparing polymer modifier-containing filler and remarkably enhancing filler retention and the like.

A process for preparing antibacterial chitosan and its spinning solution includes such steps as degradating chitosan, reacting on benzaldehyde, reacting of the resultant on 3-chloro-ammonium hydroxypropyltrimethyl chloride and chlorinated ammonium methacryloyloxy trimethyl chloride in isopropanol to obtain O-chitosan quaternary ammonium derivative, and adding its aqueous solution or dispersed DMAc to the queous solution of cellulose NMMO/H2O or LiCl/DMAc solution.

The invention discloses a fabric formaldehyde-free fixing agent. The fixing agent comprises the following raw materials in parts by mass: 10-15 parts of poly dimethyl diallyl ammonium chloride, 15-18 parts of 2-hydroxypropyltrimethyl ammonium chloride chitosan, 25-34 parts of water, 20-25 parts of ethanol and 5-10 parts of fatty alcohol polyoxyethylene ether. The fixing agent disclosed by the invention has an excellent fixation effect, and can effectively improve colour fastness of fabric dyes and wet rubbing fastness in the processes of dyeing and printing. The fabric treated by the fabric formaldehyde-free fixing agent does not discolor.

The invention discloses a preparation method and application of a marine organism active hemostasis dressing. The preparation method comprises the steps of adding equal sodium alga acid solution while stirring a water solution comprising hydroxypropyl trimethyl ammonium chloride chitosan and/or an acetum of chitosan so as to obtain a liquor 1, taking an emulsion comprising paraffin as a liquor 2, mixing the liquor 1 and the liquor 2 according to the proportion of (2-3):5 and stirring uniformly so as to obtain a stable emulsification system, adding a cross-linking agent calcium chloride solution for cross-linking and solidifying the emulsification system, then washing, dewatering and drying so as to obtain the marine organism active hemostasis dressing. The materials of the prepared microballoon product have good biocompatibility and biodegradability as well as special effects of resisting bacterium, stopping bleeding, and promoting healing, when being contacted with a wound, the cross-linking and solidification product can rapidly absorb moisture in blood and concentrate blood platelets and blood coagulation factors into sticky gel, thus effectively sealing the bleeding wound and enhancing the hemostasis performance of the microballoon material, and therefore, the marine organism active hemostasis dressing is stable, efficient and environment-friendly.

The invention provides a preparation method of a chitosan quaternary ammonium HTCC/polyethersulfone (PES) positively charged composite nanofiltration membrane. According to the preparation method, positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC) is used as a surface-active functional layer, a polyethersulfone ultrafilter membrane with good hydrophilic performance is used as a supporting layer, epoxy chloropropane (ECH) is used as a cross-linking agent, and a coating and crosslinking reaction method is adopted to prepare the positively charged chitosan composite nanofiltration membrane. The preparation method has a simple technology and is natural and environmentally friendly. The positively charged composite nanofiltration membrane prepared by the above method has good hydrophilic performance and excellent mechanical property. Water flux under the operating pressure of 0.4 MPa is 4.77-8.96L.m<-2>.h<-1>, and the positively charged composite nanofiltration membrane has high retention rate for organic matters with molecular weight being more than 600 and inorganic salt solutions such as MgCl2 and the like, and can be used for separating and removing micro/trace pollutants, especially positively charged matters.

The invention provides a synthetic method of N-2-hydroxypropyl trimethyl ammonium chloride chitosan and a preparation method of Newcastle disease attenuated live vaccine-loaded nanoparticles of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan, relating to a synthetic method of chitosan and a preparation method of vaccine-loaded nanoparticles of the chitosan. The synthetic method comprises the following steps of: deacelation of the chitosan; dip-treatment of the chitosan; crude preparation of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan; and refined preparation of the N-2-hydroxypropyl trimethyl ammonium chloride chitosan. The preparation method comprises the following steps of: adding a Newcastle disease virus solution into an N-2-hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain a solution A; adding sodium tripolyphosphate, PBS (phosphate buffer solution) and span-80 into the solution A to obtain a solution B; and centrifuging the solution B to obtain a deposit, adding PBS for suspension, adding mycose skimmed milk, and performing freeze drying to finish the preparation. The nanoparticles prepared by using the method has the advantages of easiness in control of particle size, small particle size of drug-loaded nanoparticles, high entrapment efficiency, large drug-loading quantity, mild preparation conditions, low drug toxic or side effect, long slow release time, simple preparation process, lower production cost and easiness in large-scale production.

The invention relates to a synthesis method of similar quaternized chitosan sunscreen and an application of the quaternized chitosan sunscreen as hair sunscreen, belonging to the technical field of functional cosmetic. The product in the invention is obtained through the following two reaction steps: first step, 2-hydroxypropyltrimethyl ammonium chloride chitosan is synthesized from 3-chloro-2-hydroypropyltrimethyl amino and chitosan under alkali condition; second step, 2-hydroxypropyltrimethyl ammonium chloride chitosan is dissolved in dimethyl sulfoxide, and acyl chloride (sulfonyl chloride) and bind acid agent triethylamine are added in the solution to synthesize the final product quaternized chitosan sunscreen. Wherein, the acyl chloride (sulfonyl chloride) group grafted in the second step has quite strong ultraviolet absorption performance; besides, grafting quaternary ammonium group on the chitosan not only improves the water solubility of the chitosan and enlarges the application scope, but also enables the product to adhere to hairs with negative electricity. Measurement of tryptophan content in hairs proves that the product has sun-screening effect for hairs to some extent.

The invention relates to a preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber, which belongs to the field of fiber material preparation. The preparation method is characterized in that quaternary ammonium salt groups are introduced onto chitin fiber molecular chains through the ring opening reaction between the amino groups on the chitin molecular chains and epoxy groupson 2, 3-epoxypropyl trimethyl ammonium chloride molecules, so the polycation characteristic of the chitin fiber is enhanced, and the antibacterial property of the chitin fiber is improved. The goal of maintaining the substituting degree of the hydroxypropyl trimethyl ammonium chloride chitin fiber to be in a range being 4 to 80 percent is realized through controlling the reaction conditions and the mol ratio of the glucosamine residue of the chitin fiber to the epoxypropyl trimethyl ammonium chloride, so the chitin fiber after the reaction has high antibacterial property, a large amount of liquid can also be absorbed, the basic form of the fiber can still be maintained after the liquid absorption, and the liquid absorption performance of the chitin fiber is enhanced. The preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber is simple, the cost is low, and the industrial production is easy to realize.

The invention discloses a preparation method of a positively charged graphene oxide/quaternized chitosan composite nanofiltration membrane prepared through layer-by-layer self-assembly. The method comprises the step that the positively charged graphene oxide/quaternized chitosan composite nanofiltration membrane is prepared through a layer-by-layer self-assembly method by taking positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan as a polycation electrolyte, taking graphene oxide as a polyanion electrolyte, taking a polyethersulfone ultrafiltration membrane which is good in hydrophilic performance as a supporting layer and taking epichlorohydrin as a cross-linking agent. The preparation method is simple, natural, environmentally friendly and good in stability, the prepared positively charged composite nanofiltration membrane has the good hydrophilic performance and the excellent separating effect, the pure water permeability coefficient is 24.02 L.h<-1>.m<-2>.Mpa, the molecular weight cut-off is 1,313, and the molecular weight cut-off of the nanofiltration membrane ranges from 150 to 2,000, and the prepared positively charged composite nanofiltration membrane belongs to the nanofiltration membrane category. The composite membrane has the high retention rate on high-valence cation compounds and can be used for treatment of micro-balanced pollutants in a water environment and particularly separating and removing of positively charged materials.

The invention relates to a method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres. The nano drug carrying microspheres are prepared by reacting a 2-hydroxypropyltrimethyl ammonium chloride chitosan aqueous solution containing a drug with a carboxymethyl konjac glucomannan aqueous solution for a polyelectrolyte complex reaction. Compared with the existing drug, the nano drug carrying microspheres prepared using the method provided by the invention have the characteristics of being better in biocompatibility, smaller in particle size, higher in encapsulation efficiency, and good in slow release performance, and can prolong the half-life period of the drug in vivo and fully exert the medical effect.

The invention discloses a scar recovery dressing and a preparation method thereof. The scar recovery dressing is formed via sequential stacking of such raw materials as pressure-sensitive adhesive plaster, an electret film, a water absorbent cotton compression film, a physical curing film, a PE (polyurethane) anti-sticking mesh film and isolating protective paper. The electret film is formed via a way that constant-voltage corona charging is carried out at a polytetrafluoroethylene porous film at the room temperature via an ME-TL type high-voltage static corona system until static charges on the surface reach 200-20000V; and the physical curing film is formed via full saturation, taking-out and drying of a dressing in physical curing solution, and is prepared with such raw materials as hydroxypropyl trimethyl ammonium chloride chitosan or carboxymethyl chitosan, ethanol-extracted concentrate of rheum officinale and pseudo-ginseng, water-extracted trogopterus dung and a film forming agent. The physical treatment and chemical treatment can be achieved via the scar recover dressing for a scar, the scar curing can be promoted, the size of the scar can be reduced, and the good recoveryeffect can be achieved on the formed scar. Therefore, the scar recovery dressing has dual functions.

The invention discloses a heat-proof freeze-dried protective agent and a preparation method and application thereof. The heat-proof freeze-dried protective agent is prepared by mixing a solution A and a solution B according to the volume ratio of 1:1, wherein the solution A comprises 0.01-0.03 g/ml of trehalose, 0.01-0.04 g/ml of sodium thiosulfate, 0.01-0.02 g/ml of casein enzymatic hydrolysate, 0.01-0.02 g/ml of thiocarbamide, 0.005-0.02 g/ml of 199 culture medium and 0.001-0.01 g/ml of O-2'-hydroxypropyl trimethyl ammonium chloride chitosan, is dissolved and determined in volume by using a polyvinyl pyrrolidone (PVPK30) water solution with the mass percent concentration of 2%-6%, and is disinfected by using 0.22 micrometer filter; the solution B contains 0.01-0.03 g/ml of gelatin, 0.05-0.1 g/ml of peptone and 0.05-0.1 g/ml of sucrose, is dissolved and determined in volume by using deionized water, and is autoclaved for later use. Compared with the existing product, the improved heat-proof freeze-dried protective agent disclosed by the invention can increase the protection duration of a product, furthest maintain the virus titer and shorten the freeze-drying time, and is long in antibody duration time and favorable to use in industrialized large-scale production.

A preparation method of an N-2-hydroxypropyl trimethyl ammonium chloride chitosan/ N,O-carboxymethyl chitosan naonparticle relates to a preparation method of the chitosan naonparticle. The method comprises the following steps of: 1, taking an N-2-hydroxypropyl trimethyl ammonium chloride chitosan solution, dripping an N,O-carboxymethyl chitosan naonparticle solution therein, stirring magnetically at a room temperature and under a sterile condition, and obtaining a solution A; and 2, centrifugating the solution A, eluting the deposit with deionized water for three times and performing freeze drying under vacuum to obtain the N-2-hydroxypropyl trimethyl ammonium chloride chitosan/ N,O-carboxymethyl chitosan naonparticle. Compared with the chitosan naonparticle, the N-2-hydroxypropyl trimethyl ammonium chloride chitosan/ N,O-carboxymethyl chitosan naonparticle obtained by the method has the advantages that the particle diameters can be easily controlled and are uniformly distributed, the biological compatibility is good, the stability is high, and has the characteristics of good water solubility, electropositive property and the like; in the process of preparing the nanoparticle, the safety and the nontoxicity are achieved; the preparation process is simple; the operation is simple; the preparation conditions are mild; the cost is low; and the N-2-hydroxypropyl trimethyl ammonium chloride chitosan/ N,O-carboxymethyl chitosan naonparticle can be easily produced on a large scale.

The invention discloses a method for continuously extracting alliin, garlic polysaccharide and odorless garlic powder by taking fresh garlic as a raw material. The method is characterized by comprising the following steps: a, heating and passivating garlic cloves in a microwave to obtain allinase, adding purified water, smashing into homogenate, heating, stirring, extracting and performing residue-liquid separation in sequence, and drying and crushing the residues to obtain the odorless garlic powder; b, treating a liquid phase by an HACC (Hydroxypropyltrimethyl Ammonium Chloride Chitosan) and a CTS-I type natural clarifying agent and then separating, adsorbing the alliin with 001*7 strong acid cation exchange resin, wherein effluent is the garlic polysaccharide, and performing evaporation, concentration and spray drying to obtain garlic polysaccharide powder; c, flushing the resin adsorbed with the alliin by using purified water to be clean, and then eluting with an ammonia-water solution, and performing deamination and concentration under reduced pressure, ethanol recrystallization and vacuum drying on eluant to obtain an alliin finished product. The method disclosed by the invention has the advantages that the cost ratio of garlic as the raw material in the product is greatly reduced, the market competitiveness of the product is improved, and the productivity is improved; no other pollutants are discharged, so the environment is protected.

The invention discloses an effective treatment method for methyl orange dye wastewater. The effective treatment method specifically comprises the following steps: firstly, by taking an aluminum foil as a substrate, preparing a honeycomb-shaped zinc oxide nano wall array, and plating the surface of the array with a layer of silver nanoparticles so as to obtain a catalyst; secondly, by taking 2-hydroxypropyl trimethyl ammonium chloride chitosan modified activated carbon as an adsorbent, putting the adsorbent into methyl orange dye wastewater firstly when the dye wastewater is treated, performing stirring adsorption for 10 hours at a pH value of 10.5 at the room temperature, filtering, and collecting filtrate; and putting the prepared catalyst into the collected filtrate, adjusting the pH value to 6, performing stirring treatment for 1-3 hours under a light shielded condition, performing stirring treatment for 20-60 minutes with visible light, filtering after the treatment is completed, and recycling the catalyst. By adopting the effective treatment method, dye molecules in wastewater can be effectively removed, and the treatment cost is lowered.

The invention relates to the industries of food and biological medicine, in particular to a hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and a preparation method and application thereof. The hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt is as shown in formula (1) (the formula is shown in the description). The hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt has the advantages that the reaction process is simple, the conditions are mild, the reaction materials are cheap and easy to obtain, the promotion and industrial application are easy, and the research proves that the hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt is good in water solubility, has extremely good moisture absorbing and moisturizing activity, and can be widely applied in the cosmetic field and the pharmaceutical industry.

The invention provides a preparation method of quaternized chitosan HTCC/CA/TiO2 hybrid membrane. The preparation method comprises following steps: positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC) and cellulose acetate (CA) are blended so as to obtain an organic substrate; nano TiO2 is introduced; ultrasonic dispersing and standing defoaming under vacuum conditions are performed; and the organic-inorganic HTCC/CA/TiO2 hybrid membrane is obtained via solution blending. The preparation method is simple; cost is relatively low; and the quaternized chitosan HTCC/CA/TiO2 hybrid membrane is natural and is friendly to the environment. The quaternized chitosan HTCC/CA/TiO2 hybrid membrane possesses excellent mechanical properties, swelling performance, and ion exchange capacity; possesses excellent antibacterial performance on gram-negative bacteria E.coliRosetta and E.coliDH5alpha, and gram-positive bacterium Bacillussubtilis; and can be used for separation purification of some sewage containing trace pollutants in the field of biochemistry and environmental engineering.

The invention discloses temperature-sensitive hydrogel for treating wounds and a preparation method of the temperature-sensitive hydrogel, and relates to the field of hydrogel dressings, in particular to the temperature-sensitive hydrogel and the preparation method of the temperature-sensitive hydrogel. The invention aims to solve the problem that the existing hydrogel wound dressing prepared from chitosan has poor solubility and is limited by pH. The hydrogel is prepared from N-2-hydroxypropyl trimethyl ammonium chloride chitosan, lactic acid and a sodium glycerophosphate solution. The method comprises the following steps: 1, preparing N-2-hydroxypropyl trimethyl ammonium chloride chitosan; and 2, under ice bath stirring, dropwise adding a sodium glycerophosphate solution into the N-2-HACC lactic acid solution, and carrying out a reaction for 30-40 min to obtain an N-2-HACC hydrogel solution. The preparation method is used for preparing the temperature-sensitive hydrogel for treating wounds.