Preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber

A technology of hydroxypropyltrimethylammonium chloride and chitosan fiber, which is applied in fiber treatment, textiles and papermaking, etc., can solve the problems of weakened antibacterial properties of chitosan fiber, reduction of amino content, complex products, etc., to increase poly Cationic properties, simple preparation method, and effect of improving antibacterial properties

Active Publication Date: 2012-03-14
JIANGSU NEWVALUE MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these modification methods, on the one hand, the position of the reaction substituent is uncertain, which makes the product more complicated, and the distribution of the substituent has an uncertain impact on its liquid absorption; Carrying out on the amino group of the molec

Method used

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  • Preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber

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Embodiment 1

[0034] Weigh 5g of chitosan fiber and disperse it in 100mL methanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir evenly at room temperature; then add 10.0g of 20wt% NaOH solution at room temperature After stirring uniformly, after reacting in a constant temperature water bath at 50°C for 0.5h, the reacted chitosan fiber and the reaction mixture are separated, and the separated chitosan fiber is dispersed in 80v% methanol aqueous solution, and 15v% is added dropwise Acetic acid aqueous solution, adjust the pH of the methanol and acetic acid aqueous solution mixture to 7.1, soak for 30 minutes, then separate the soaked chitosan fiber from the mixture, wash twice with 80v% methanol aqueous solution, and after dehydration, at 40℃ After drying, a hydroxypropyltrimethylammonium chloride chitosan fiber with a degree of substitution of 4% is obtained.

Embodiment 2

[0036] Weigh 5g of chitosan fiber and disperse it in 100mL of butanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir evenly at room temperature; then add 10.0g of 25wt% NaOH solution at room temperature After stirring uniformly, react for 0.5h in a constant temperature water bath at 50℃, separate the reacted chitosan fiber from the reaction mixture, and disperse the separated chitosan fiber in 80v% acetone aqueous solution, and add 15v dropwise % Acetic acid aqueous solution, adjust the pH of the acetone and acetic acid aqueous solution mixture to 6.0, soak for 30 minutes, and then separate the soaked chitosan fiber from the mixture, wash it twice with 80v% acetone aqueous solution, and dehydrate it at 40℃ Drying under the conditions to obtain hydroxypropyltrimethylammonium chloride chitosan fiber with a degree of substitution of 5%.

Embodiment 3

[0038] Weigh 5g of chitosan fiber and disperse it in 100mL of propanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir evenly at room temperature; then add 10.0g of 20wt% KOH solution at room temperature After stirring uniformly, react for 0.5h in a constant temperature water bath at 50℃, separate the reacted chitosan fiber and the reaction mixture, and disperse the separated in 80v% ethanol aqueous solution, and dropwise add 15v% acetic acid aqueous solution , Adjust the pH of the ethanol and acetic acid aqueous solution mixture to 8.0, soak for 30 minutes, and then separate the soaked chitosan fiber from the mixture, wash twice with an 80v% ethanol aqueous solution, and then dry at 40°C after dehydration , Get the hydroxypropyl trimethyl ammonium chloride chitosan fiber with a degree of substitution of 5%.

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Abstract

The invention relates to a preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber, which belongs to the field of fiber material preparation. The preparation method is characterized in that quaternary ammonium salt groups are introduced onto chitin fiber molecular chains through the ring opening reaction between the amino groups on the chitin molecular chains and epoxy groupson 2, 3-epoxypropyl trimethyl ammonium chloride molecules, so the polycation characteristic of the chitin fiber is enhanced, and the antibacterial property of the chitin fiber is improved. The goal of maintaining the substituting degree of the hydroxypropyl trimethyl ammonium chloride chitin fiber to be in a range being 4 to 80 percent is realized through controlling the reaction conditions and the mol ratio of the glucosamine residue of the chitin fiber to the epoxypropyl trimethyl ammonium chloride, so the chitin fiber after the reaction has high antibacterial property, a large amount of liquid can also be absorbed, the basic form of the fiber can still be maintained after the liquid absorption, and the liquid absorption performance of the chitin fiber is enhanced. The preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber is simple, the cost is low, and the industrial production is easy to realize.

Description

Technical field [0001] The invention relates to a preparation method of antibacterial hydration chitosan fiber, in particular to a preparation method of hydroxypropyltrimethylammonium chloride chitosan fiber, which belongs to the field of fiber material preparation. Background technique [0002] Chitin is a renewable resource with reserves second only to cellulose on the earth. Its deacetylated derivative, chitosan, has good biocompatibility, biodegradability, hemostasis, and promotion of wound healing. Absorbable surgical sutures, wound dressings, drug carrier materials, artificial skin and other tissue engineering scaffold materials have broad application prospects. [0003] The chitosan is dissolved in an organic acid or an inorganic acid to form a viscous colloid. After coagulation and dehydration, chitosan fibers can be prepared, which are used to prepare wound dressings. Japanese Patent Publication (JP 60,059,123, 1985), Chinese Patent Publication No. CN1129748, publication ...

Claims

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Application Information

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IPC IPC(8): D06M13/463
Inventor 周应山徐卫林
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
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