Preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber

A technology of hydroxypropyl trimethyl ammonium chloride and chitosan fiber, which is used in fiber treatment, textiles and papermaking, etc., can solve the problems of weakening the antibacterial property of chitosan fiber, reducing the amino content, and restricting the application, so as to increase the polymer Cationic properties, simple preparation method, and effect of killing bacteria on wound surfaces

Active Publication Date: 2013-04-17
JIANGSU NEWVALUE MEDICAL PROD CO LTD
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these modification methods, on the one hand, the position of the reaction substituent is uncertain, which makes the product more complicated, and the distribution of the substituent has an uncertain impact on its liquid absorption; Carrying out on the amino group of the molecular chain, so as to reduce the content of the amino group, resulting in further weakening of the antibacterial properties of the chitosan fiber
These problems will greatly limit the clinical application of dressings prepared from chitosan fibers, especially for burns and chronic wounds.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 5g of chitosan fibers and disperse them in 100mL of methanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir at room temperature; then add 10.0g of 20wt% NaOH solution, and After stirring evenly, react in a constant temperature water bath at 50°C for 0.5h, separate the reacted chitosan fibers from the reaction mixture, and disperse the separated chitosan fibers in 80v% methanol aqueous solution, add dropwise 15v% Acetic acid aqueous solution, adjust the pH of the mixture of methanol and acetic acid aqueous solution to 7.1, soak for 30 minutes, then separate the soaked chitosan fibers from the mixed solution, wash twice with 80v% methanol aqueous solution, and dehydrate at 40°C Drying under the hood to obtain hydroxypropyltrimethylammonium chloride chitosan fiber with a substitution degree of 4%.

Embodiment 2

[0036] Weigh 5g of chitosan fiber and disperse it in 100mL of butanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir at room temperature; then add 10.0g of NaOH solution with a concentration of 25wt%, and After stirring evenly at high temperature, react in a constant temperature water bath at 50°C for 0.5h, separate the reacted chitosan fibers from the reaction mixture, and disperse the separated chitosan fibers in 80v% acetone aqueous solution, add dropwise 15v % acetic acid aqueous solution, adjust the pH of the mixture of acetone and acetic acid aqueous solution to 6.0, soak for 30 minutes, then separate the soaked chitosan fibers from the mixed solution, wash twice with 80v% acetone aqueous solution, and after dehydration, dry at 40°C drying under the condition to obtain hydroxypropyltrimethylammonium chloride chitosan fiber with a substitution degree of 5%.

Embodiment 3

[0038] Weigh 5g of chitosan fiber and disperse it in 100mL propanol, add 0.470g of 2,3-epoxypropyltrimethylammonium chloride, shake and stir at room temperature; then add 10.0g of 20wt% KOH solution, After stirring evenly at high temperature, react in a constant temperature water bath at 50°C for 0.5h, separate the reacted chitosan fibers from the reaction mixture, and disperse the separated chitosan fibers in 80v% ethanol aqueous solution, and add 15v% acetic acid aqueous solution dropwise , adjust the pH of the mixture of ethanol and acetic acid aqueous solution to 8.0, soak for 30 minutes, then separate the soaked chitosan fibers from the mixed solution, wash twice with 80v% ethanol aqueous solution, dehydrate, and dry at 40°C , to obtain hydroxypropyltrimethylammonium chloride chitosan fibers with a substitution degree of 5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber, which belongs to the field of fiber material preparation. The preparation method is characterized in that quaternary ammonium salt groups are introduced onto chitin fiber molecular chains through the ring opening reaction between the amino groups on the chitin molecular chains and epoxy groupson 2, 3-epoxypropyl trimethyl ammonium chloride molecules, so the polycation characteristic of the chitin fiber is enhanced, and the antibacterial property of the chitin fiber is improved. The goal of maintaining the substituting degree of the hydroxypropyl trimethyl ammonium chloride chitin fiber to be in a range being 4 to 80 percent is realized through controlling the reaction conditions and the mol ratio of the glucosamine residue of the chitin fiber to the epoxypropyl trimethyl ammonium chloride, so the chitin fiber after the reaction has high antibacterial property, a large amount of liquid can also be absorbed, the basic form of the fiber can still be maintained after the liquid absorption, and the liquid absorption performance of the chitin fiber is enhanced. The preparation method of hydroxypropyl trimethyl ammonium chloride chitin fiber is simple, the cost is low, and the industrial production is easy to realize.

Description

technical field [0001] The invention relates to a preparation method of antibacterial hydration chitosan fiber, in particular to a preparation method of hydroxypropyltrimethylammonium chloride chitosan fiber, which belongs to the field of preparation of fiber materials. Background technique [0002] Chitin is a renewable resource second only to cellulose in reserves on the earth. Its deacetylated derivative chitosan, due to its good biocompatibility, biodegradability, hemostasis, and promotion of wound healing, makes it widely used in Absorbable surgical sutures, wound dressings, drug carrier materials, artificial skin and other tissue engineering scaffold materials have broad application prospects. [0003] Dissolve chitosan in organic acid or inorganic acid to form viscous colloid. After coagulation and dehydration, chitosan fiber can be obtained, which can be used to prepare wound dressings. Japanese Open Patent Gazette (JP 60,059,123, 1985), Chinese Patent Publication N...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): D06M13/463
Inventor 周应山徐卫林
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap