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Temperature-sensitive hydrogel for treating wounds and preparation method thereof

A hydrogel, temperature-sensitive technology, applied in bandages, medical science, etc., can solve problems such as poor solubility, achieve good porosity, good water storage performance, and reduce skin irritation

Inactive Publication Date: 2022-05-13
TAIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that existing hydrogel wound dressings made of chitosan have poor solubility and are limited by pH, and provide a temperature-sensitive hydrogel for treating wounds and a preparation method thereof

Method used

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  • Temperature-sensitive hydrogel for treating wounds and preparation method thereof
  • Temperature-sensitive hydrogel for treating wounds and preparation method thereof
  • Temperature-sensitive hydrogel for treating wounds and preparation method thereof

Examples

Experimental program
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specific Embodiment approach 1

[0033] Embodiment 1: The temperature-sensitive hydrogel for treating wounds in this embodiment is made of N-2-hydroxypropyltrimethylammonium chloride chitosan, lactic acid and sodium glycerophosphate solution. The sodium glycerophosphate solution contains α-sodium glycerophosphate and β-sodium glycerophosphate.

[0034] The present invention synthesizes hydrophilic quaternized chitosan N-2-HACC through chemical modification, and uses N-2-HACC as raw material, α-sodium glycerophosphate and β-sodium glycerophosphate as cross-linking agents, A temperature-sensitive quaternized chitosan hydrogel (N-2-HACC Hydrogel) was prepared. The invention can be used as a wound dressing, a wound healing drug and a drug delivery carrier. The use process is convenient and the safety is high. The hydrogel preparation The method is simple and easy for industrialization and clinical application.

specific Embodiment approach 2

[0035] Specific embodiment two: the preparation method of the temperature-sensitive hydrogel for treating wounds in this embodiment includes the following steps:

[0036] 1. Preparation of N-2-HACC with controllable degree of substitution

[0037] 1. Chitosan soaking treatment

[0038] Dissolve chitosan in acetic acid solution, add NaOH solution drop by drop after stirring, adjust to pH = 9, soak for 0.5-1h, filter with suction, wash and precipitate with deionized water until neutral, freeze-dry in vacuum until the mass is m, Chitosan obtained after treatment; The concentration of the NaOH solution is 15mol / L;

[0039] 2. Ring-opening reaction of chitosan and glycidyltrimethylammonium chloride

[0040] Disperse the treated chitosan in isopropanol, stir evenly, add the isopropanol solution of 2,3-epoxypropyltrimethylammonium chloride dropwise after heating up to 80-85°C, and dissolve in 30min After the internal dropwise addition, stir at a constant temperature of 80-85°C for...

specific Embodiment approach 3

[0045] Specific embodiment three: the difference between this embodiment and specific embodiment two is: the volume ratio of acetic acid and deionized water in the acetic acid solution in step one is (1~15):(20~40). Others are the same as in the second embodiment.

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Abstract

The invention discloses temperature-sensitive hydrogel for treating wounds and a preparation method of the temperature-sensitive hydrogel, and relates to the field of hydrogel dressings, in particular to the temperature-sensitive hydrogel and the preparation method of the temperature-sensitive hydrogel. The invention aims to solve the problem that the existing hydrogel wound dressing prepared from chitosan has poor solubility and is limited by pH. The hydrogel is prepared from N-2-hydroxypropyl trimethyl ammonium chloride chitosan, lactic acid and a sodium glycerophosphate solution. The method comprises the following steps: 1, preparing N-2-hydroxypropyl trimethyl ammonium chloride chitosan; and 2, under ice bath stirring, dropwise adding a sodium glycerophosphate solution into the N-2-HACC lactic acid solution, and carrying out a reaction for 30-40 min to obtain an N-2-HACC hydrogel solution. The preparation method is used for preparing the temperature-sensitive hydrogel for treating wounds.

Description

technical field [0001] The invention relates to the field of hydrogel dressings, in particular to a temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] With the development of the times, the occurrence of trauma can be seen everywhere, and the issue of wound healing is becoming more and more important clinically. Due to the different conditions, the degree of injury of the wound is different. At the same time, the wound is also prone to infection and easy to destroy the stability of the internal environment of the body. The complex environment of the skin makes it difficult or even impossible for traditional wound dressings to meet people's needs for high-quality wound repair and management. Therefore, there is an urgent need for new biomedical dressings that can accelerate wound healing. [0003] As a wound auxiliary material, hydrogel can not only play a barrier function to prevent the invasion of exogenous foreign bodies, but a...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08K5/521C08B37/08C08J3/075A61L26/00
CPCC08J3/075A61L26/0023A61L26/008A61L26/0085A61L26/009C08B37/003C08J2305/08C08K2201/014C08K5/521C08L5/08
Inventor 赵凯金政
Owner TAIZHOU UNIV
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