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Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres

A technology of konjac glucomannan and nano-drug-carrying, which can be applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of slow swelling rate of konjac glucomannan and stable sol. problems such as poor performance, to achieve the effect of short cycle, high encapsulation efficiency and protection activity

Inactive Publication Date: 2015-11-18
HUAZHONG AGRI UNIV
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  • Summary
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Carboxymethyl konjac glucomannan is the product of konjac glucomannan modified by carboxymethylation. It not only retains the excellent biological properties of konjac glucomannan, but also overcomes the slow swelling rate of konjac glucomannan, Disadvantages such as poor stability of sol

Method used

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  • Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres
  • Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres
  • Method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres

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Embodiment 1

[0031] 1. Preparation of carboxymethyl konjac glucomannan:

[0032] (1) Accurately measure 70mL of concentrated hydrochloric acid, and dilute to 250mL with absolute ethanol; then accurately weigh 35g of konjac glucomannan and put it into a three-neck flask, add 250mL of prepared ethanol hydrochloric acid solution, and mechanically Stirring and reacting for 2 hours; after the reaction, the product was washed with 70 wt% ethanol aqueous solution to neutrality, filtered under reduced pressure, and vacuum-dried at 30° C. for 16 hours to obtain acid-hydrolyzed konjac glucomannan. It is 1.68mpa.s (and the absolute viscosity of the konjac glucomannan before acidolysis is 82.1mpa.s, measuring solution is 1wt% with NDJ-79 rotary viscometer to measure the konjac glucomannan absolute viscosity after the acid hydrolysis aqueous solution).

[0033] (2) Preparation of carboxymethyl konjac glucomannan: first accurately weigh 10 g of acid-hydrolyzed konjac glucomannan and put it into a three...

Embodiment 2

[0044] Preparation of ovalbumin-carboxymethyl konjac glucomannan nanoparticle drug-loaded microspheres

[0045] The preparation method of carboxymethyl konjac glucomannan and 2-hydroxypropyltrimethylammonium chloride chitosan is the same as in Example 1.

[0046] 1) 4ml concentration is that the ovalbumin aqueous solution of 2mg / mL slowly joins in the 2-hydroxypropyltrimethylammonium chloride chitosan aqueous solution that 10ml concentration is 1.5mg / mL, stirs and regulates the pH of mixed solution to neutral;

[0047] 2) Slowly add 5 ml of carboxymethyl konjac glucomannan aqueous solution with a concentration of 2 mg / mL dropwise to the mixed solution in step 1) while stirring, and continue to stir and react for 15 minutes;

[0048] 3) centrifuging the reaction solution, washing the separated precipitate with water and freeze-drying to obtain ovalbumin-carboxymethyl konjac glucomannan nano drug-loaded microspheres.

[0049] The particle size distribution and zeta potential o...

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Abstract

The invention relates to a method for preparing carboxymethyl konjac glucomannan nano drug carrying microspheres. The nano drug carrying microspheres are prepared by reacting a 2-hydroxypropyltrimethyl ammonium chloride chitosan aqueous solution containing a drug with a carboxymethyl konjac glucomannan aqueous solution for a polyelectrolyte complex reaction. Compared with the existing drug, the nano drug carrying microspheres prepared using the method provided by the invention have the characteristics of being better in biocompatibility, smaller in particle size, higher in encapsulation efficiency, and good in slow release performance, and can prolong the half-life period of the drug in vivo and fully exert the medical effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of carboxymethyl konjac glucomannan nano drug-loaded microspheres. Background technique [0002] As a resource-rich natural polymer material, polysaccharides have good biocompatibility and degradability, and most natural polysaccharide molecules contain hydrophilic groups such as carboxyl, hydroxyl and amino groups, which can interact with biological Functional macromolecules in the body undergo strong non-covalent bonding, which in turn affects life activities. Therefore, natural polysaccharides have very bright prospects as biomaterials. [0003] Konjac is a perennial herb of Araceae Konjac genus, and its tubers can be processed to obtain konjac fine powder. The main component of purified konjac powder is konjac glucomannan. Regular consumption of konjac glucomannan can not only relieve constipation and lose weight, but also reduce b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K31/513A61K38/38C08B37/02C08B37/08
Inventor 王运石丛姣朱佩
Owner HUAZHONG AGRI UNIV
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