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Hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and preparation method and application thereof

The technology of hydroxypropyl trimethyl ammonium chloride and glycidyl trimethyl ammonium chloride is applied in the field of hydroxypropyl trimethyl ammonium chloride chitosan-carboxy polysaccharide composite salt and preparation thereof, and can Solve the problems of poor moisture absorption and moisturizing activity, and achieve the effect of low material cost, good water solubility and wide application

Active Publication Date: 2019-05-17
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan has some hygroscopic and moisturizing activity, but its hygroscopic and moisturizing activity is poor compared with hyaluronic acid, which is not enough to be developed as a hygroscopic humectant substitute

Method used

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  • Hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and preparation method and application thereof
  • Hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and preparation method and application thereof
  • Hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In this example, the target compound hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide complex salt was synthesized according to the above synthetic route.

[0041] 1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 20mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 13.59 g, reacted at 55-65°C for 9 hours; then added 60mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0042]2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-carboxymethyl chitosan salt: 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above was dissolved in 20 mL of deionized water, and then Weigh 3.72 g carboxymethyl chitosan and dissolve it in 74 mL deionized water, t...

Embodiment 2

[0044] The difference from Example 1 is:

[0045] 1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 30mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 19.32 g, reacted at 55-65°C for 12 hours; then added 70mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0046] 2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-carboxymethyl inulin salt: 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above was dissolved in 30 mL deionized water, and weighed Take 3.73 g carboxymethyl inulin and dissolve it in 37 mL of deionized water, then slowly add carboxymethyl inulin aqueous solution to the former, react at room temperature for 18 hours, then transfer the mixed solution to...

Embodiment 3

[0048] The difference from Example 1 is:

[0049] 1) Preparation of hydroxypropyltrimethylammonium chloride chitosan: Weigh 4.83 g chitosan and disperse it in 40mL isopropanol to swell at room temperature, add 2,3-epoxypropyltrimethylammonium chloride 24.15 g, reacted at 55-65°C for 12 hours; then added 80mL of methanol for alcohol precipitation, the resulting precipitate was washed with 85% ethanol and suction filtered to obtain a filter cake, and dried to constant weight to obtain hydroxypropyltrimethyl chloride ammonium chitosan;

[0050] 2) Preparation of hydroxypropyltrimethylammonium chloride chitosan-hyaluronic acid sodium salt: Dissolve 3.42 g of hydroxypropyltrimethylammonium chloride chitosan obtained above in 40 mL of deionized water, and then weigh 4.08 g of sodium hyaluronate was dissolved in 27 mL of deionized water, and then the sodium hyaluronate aqueous solution was slowly added dropwise to the former at room temperature to react for 24 hours, and then the mi...

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Abstract

The invention relates to the industries of food and biological medicine, in particular to a hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt and a preparation method and application thereof. The hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt is as shown in formula (1) (the formula is shown in the description). The hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt has the advantages that the reaction process is simple, the conditions are mild, the reaction materials are cheap and easy to obtain, the promotion and industrial application are easy, and the research proves that the hydroxypropyl trimethyl ammonium chloride chitosan-carboxyl polysaccharide compound salt is good in water solubility, has extremely good moisture absorbing and moisturizing activity, and can be widely applied in the cosmetic field and the pharmaceutical industry.

Description

technical field [0001] The invention relates to food and biomedicine industries, in particular to a hydroxypropyltrimethylammonium chloride chitosan-carboxypolysaccharide compound salt and a preparation method and application thereof. Background technique [0002] Hygroscopic humectants are a class of hygroscopic compounds that can absorb moisture from humid air, and achieve moisturizing, moisturizing and other effects by absorbing and retaining moisture. Hygroscopic moisturizers are mainly used in food and daily chemical fields. Moisturizer is an indispensable and important ingredient in cosmetics. Hyaluronic acid derived from organisms is an excellent moisturizer. It is used in high-end cosmetics to make the skin elastic and smooth, and delay skin aging. However, its raw materials are limited, the preparation process is complicated, and the cost is high, which restricts the wide application of hyaluronic acid. For this reason, people continue to research and develop the ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A23L29/30A61K8/73A61K47/36A61Q19/00
Inventor 郭占勇宓英其谭文强张晶晶陈源董方李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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