Anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application

A hydroxypropyl trimethyl ammonium chloride, anionization technology, applied in the application, cosmetic preparations, cosmetics and other directions, can solve the problem of insufficient support for development and utilization, and achieves good moisture absorption and moisturizing activity, low material cost, and high productivity. high rate effect

Active Publication Date: 2022-03-08
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chitosan has certain biological activity, it is not enough to support its large-scale development and utilization

Method used

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  • Anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application
  • Anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application
  • Anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as figure 1 The synthesis route of anionized 2-hydroxypropyltrimethylammonium chloride chitosan shown, wherein n represents the degree of polymerization, and the average value range is 50-1000.

[0037] (1) Weigh 3.38g of chitosan (molecular weight about 50,000) and disperse it in 30mL of isopropanol for swelling, add dropwise 1.2mL of 40% sodium hydroxide aqueous solution and 60% of 3-chloro - 19 mL of 2-hydroxypropyltrimethylammonium chloride solution, reacted in a metal bath reaction pot at 55°C for 9 hours, precipitated and washed with ethanol after the reaction, filtered with suction and dried to obtain 2-hydroxypropyltrimethylammonium chloride trimethylammonium chloride chitosan.

[0038] (2) Weigh 3 g of the above-mentioned 2-hydroxypropyltrimethylammonium chloride chitosan and dissolve it in 60 mL of deionized water, and then add 30 mL of an aqueous solution of sodium pyrrolidone carboxylate with a mass fraction of 15% to the former, at room temperature R...

Embodiment 2

[0040] The difference from Example 1 is:

[0041] (1) Weigh 3.38g of chitosan (molecular weight about 100,000) and disperse it in 25mL of isopropanol for swelling, add dropwise 1.4mL of sodium hydroxide aqueous solution with a mass fraction of 40%, and 60% of 3-chloro - 25 mL of 2-hydroxypropyltrimethylammonium chloride solution, reacted in a metal bath at 60°C for 10 hours, precipitated and washed with ethanol after the reaction, filtered with suction and dried to obtain 2-hydroxypropyltrimethylammonium chloride Methylammonium Chloride Chitosan.

[0042] (2) Weigh 3 g of 2-hydroxypropyltrimethylammonium chloride chitosan and fully dissolve it in 30 mL of deionized water, transfer it to a dialysis bag with a molecular weight cut-off of 500, and dialyze it in a 10% sodium lactate aqueous solution After 12 hours, dialyze with deionized water for 24 hours after the reaction, concentrate and freeze-dry to obtain sodium lactate anionized 2-hydroxypropyltrimethylammonium chloride chi...

Embodiment 3

[0044] The difference from Example 1 is:

[0045] (1) Weigh 3.38g of chitosan (molecular weight about 150,000) and disperse it in 15mL of isopropanol for swelling, add dropwise 1.6mL of 40% sodium hydroxide aqueous solution and 60% of 3-chloro - 30mL of 2-hydroxypropyltrimethylammonium chloride solution, reacted in a metal bath at 75°C for 12 hours, precipitated and washed with ethanol after the reaction, filtered with suction and dried to obtain 2-hydroxypropyltrimethylammonium chloride Methylammonium Chloride Chitosan.

[0046] (2) Weigh 3 g of the above-mentioned 2-hydroxypropyltrimethylammonium chloride chitosan, dissolve it in 20 mL of deionized water, transfer it to a dialysis bag with a molecular weight cut-off of 500, and perform a dialysis reaction in a betaine aqueous solution with a concentration of 15%. After 12 hours, dialyze with deionized water for 48 hours after the reaction, concentrate and freeze-dry to obtain betaine anionized 2-hydroxypropyltrimethylammoni...

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Abstract

The invention relates to the fields of food, cosmetics and biomedicine, in particular to anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application. The structural formula of anionized 2-hydroxypropyltrimethylammonium chloride chitosan is shown in formula (1); the advantages of the present invention are that the reaction is simple, the yield of the target compound is high, and it is easy to promote industrial application. Experiments have proved that the anionized 2-hydroxypropyltrimethylammonium chloride chitosan has good water solubility, has certain antibacterial properties, and has excellent moisture absorption and moisturizing properties, and can be widely used in the fields of food and cosmetics and the field of biomedicine. Formula (1), where n represents the degree of polymerization, and the average value range is 50‑1000.

Description

technical field [0001] The invention relates to the fields of food, cosmetics and biomedicine, in particular to anionized 2-hydroxypropyltrimethylammonium chloride chitosan and its preparation method and application. Background technique [0002] The moisture absorption and moisturizing ability of hygroscopic humectants mainly depend on the force on water molecules, and their applications mainly include food, daily chemical and other fields. Among them, sodium hyaluronate is widely used as a good hygroscopic moisturizing agent, but the preparation process of sodium hyaluronate is complicated and the cost is high. Therefore, it is necessary to find a hygroscopic moisturizing agent substitute with a wide range of sources and a lower price similar to its effect. an important subject. At the same time, hygroscopic moisturizing agents are also used in the food field, and the hydrophilicity of carbohydrates is one of the most important functional properties of food. Hygroscopic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61K8/73A61Q19/00A61K31/722A61P31/00A23L33/125A23L29/30A23L3/3562
CPCC08B37/003A61K8/736A61Q19/00A61K31/722A61P31/00A23L33/125A23L29/30A23L3/3562
Inventor 郭占勇宓英其张晶晶崔静敏李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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